Preincubation with antipsychotic drugs protects against in vitro phencyclidine-mediated spontaneous neuronal network suppression [0.03%]
抗精神病药物的预处理可以保护体内PCP介导的自发性神经网络抑制作用
Timo Jendrik Faustmann,Stephan Theiss,Philipp Görtz et al.
Timo Jendrik Faustmann et al.
Phencyclidine (PCP), a non-competitive N-methyl-D-aspartate receptor antagonist, is known to produce schizophrenia-like psychosis in humans, including positive and negative symptoms as well as cognitive dysfunction.
Resting-state functional connectivity of neural circuits associated with primary and secondary rewards linked to positive and negative symptoms of first-episode schizophrenia [0.03%]
首次发作精神分裂症患者正性及阴性症状相关的原发性和继发性奖赏神经环路静息态功能连接研究
Jing Shi,Huihui Yang,Hua Guo et al.
Jing Shi et al.
However, the underlying pathophysiology of these positive and negative symptoms remains poorly understood....In this study, we used resting-state functional connectivity (rsFC) to evaluate the integrity of neural circuits associated with primary and secondary rewards in first-episode schizophrenia (FES) and their relationship with positive and negative symptoms to better understand the physiological and pathological
M Vinu,A Georgiades
M Vinu
Physical exercise, art therapy, social recovery therapy, social skills training, virtual reality, online programmes and psychosocial interventions improved social functioning and reduced both positive and negative symptoms of psychosis.
Neuron-specific enolase in patients with acute and chronic schizophrenia, diversity of approaches: marker of neuronal death, neurodegeneration or neurodevelopmental theory in schizophrenia? a single-center case-control study [0.03%]
急性及慢性精神分裂症患者神经元特异性烯醇化酶水平差异的研究：神经元死亡、神经退行性变还是精神分裂症的神经发育理论的标志物？一项单中心病例对照研究
Alicja Sierakowska,Ewa Niewiadomska,Sebastian Łabuda et al.
Alicja Sierakowska et al.
The aim of this study was to evaluate and compare NSE concentrations in the serum of patients with schizophrenia and to determine possible relationships between NSE and the duration and severity of positive and negative symptoms of schizophrenia.
Towards a name change of schizophrenia: Positive and Negative Symptoms Disorder (PND) [0.03%]
向精神分裂症改名：阳性与阴性症状障碍（PND）
Stefan Leucht,Deniz S Yurtseven,Josef Priller et al.
Stefan Leucht et al.
We propose renaming schizophrenia to Positive and Negative Symptoms Disorder (PND) to reduce stigma, enhance clarity, and align with current diagnostic criteria. The term reflects core symptom domains, is translatable, ICD compatible, and a...
Subtyping first-episode psychosis based on longitudinal symptom trajectories using machine learning [0.03%]
基于纵向症状轨迹利用机器学习对首发精神病进行亚型划分
Yanan Liu,Sara Jalali,Ridha Joober et al.
Yanan Liu et al.
Cluster 1 exhibits lower positive and negative symptoms (LS), lower antipsychotic dose, and relatively higher affective psychosis; Cluster 2 shows lower positive symptoms, persistent negative symptoms (LPPN), and intermediate antipsychotic doses; Cluster 3 presents persistently high levels of both positive...and negative symptoms (PPNS), and higher antipsychotic doses.
Latent Trajectories of Positive, Negative Symptoms and Functioning in Early Intervention Services for First-Episode Psychosis: A 2-Year Follow-Up Study [0.03%]
首次精神病发作的早期干预服务中阳性、阴性症状和功能的功能轨迹：为期两年的随访研究
Olivier Percie du Sert,Joshua Unrau,Manish Dama et al.
Olivier Percie du Sert et al.
To better understand such heterogeneity within the context of early intervention services (EIS), this study aimed to examine latent trajectories of positive and negative symptoms and functioning among FEP individuals undergoing EIS.
N-acetylcysteine enhances the antipsychotic effect of aripiprazole in the neurodevelopmental rat model of schizophrenia [0.03%]
N-乙酰半胱氨酸增强神经发育性精神分裂症大鼠模型中艾司西酞普兰的抗精神病作用
Zofia Rogóż,Kinga Kamińska,Agnieszka Wąsik
Zofia Rogóż
Some clinical studies have shown that the atypical antipsychotic drug aripiprazole (ARI), and the antioxidant N-acetylcysteine (NAC) are effective in reducing positive and negative symptoms of schizophrenia in patients.
Systematic review and meta-analysis of the effects of EEG neurofeedback combined with pharmacological treatment on the positive and negative symptoms in patients with schizophrenia [0.03%]
系统综述和荟萃分析：脑电生物反馈联合药物治疗对精神分裂症患者阴性症状及阳性症状的影响
Yiyi Duan,ShuFan Li,Shuqi Jia et al.
Yiyi Duan et al.
Objective: To evaluate the efficacy of EEG neurofeedback (EEG-NF) combined with pharmacological treatment on positive and negative symptoms in schizophrenia.
Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte-microglia co-culture model [0.03%]
抗精神病药物对精神分裂症中小胶质细胞介导的神经炎症的影响：星形胶质细胞-小胶质细胞共培养模型中的观点
Timo Jendrik Faustmann,Franco Corvace,Pedro M Faustmann et al.
Timo Jendrik Faustmann et al.
This could lead to a better understanding of how typical and atypical antipsychotics can be used to address positive and negative symptoms in schizophrenia and comorbidities like inflammatory diseases or the status of low-grade inflammation.
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