Dual-faced guardians: SGLT2 inhibitors' kidney protection and health challenges: a position statement by Kasralainy nephrology group (KANG) [0.03%]
双面守护者：钠葡萄糖协同转运蛋白2抑制剂肾脏保护与安全性挑战——卡斯拉莱尼血液净化研究组立场声明
Amin Roshdy Soliman,Mohamed Elkhatib,Sahier El-Khashab et al.
Amin Roshdy Soliman et al.
Initially approved for type 2 diabetes management, research continually demonstrates their protective effects on kidney function across several nephrological conditions, including acute kidney injury (AKI), chronic kidney disease (CKD), dialysis-dependent kidney failure, anemia, metabolic bone disease, polycystic...kidney disease (PKD), glomerulonephritis, and kidney transplantation....SGLT2 inhibitors should not be used in autosomal dominant polycystic kidney disease (ADPKD) outside clinical trials.
A Diagnosis or a Trap: Exploring the Psychosocial and Ethical Impacts of Autosomal Dominant Polycystic Kidney Disease Diagnosis [0.03%]
ADPKD诊断的社会心理及伦理影响研究：天使or陷阱？
Mert Türk,Cuma Bülent Gül
Mert Türk
Objective: This study aimed to explore the emotional, social, and ethical dimensions of early or presymptomatic diagnosis in individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Methods: A total of 118 participants diagnos...
Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease [0.03%]
多囊肾病中的视网膜色素上皮细胞G蛋白偶联受体信号通路
Raghad Buqaileh,Lubna A Alshriem,Wissam AbouAlaiwi
Raghad Buqaileh
Polycystic kidney disease (PKD), a ciliopathy caused primarily by mutations in the Pkd1 and Pkd2 genes, disrupts renal structure and function, leading to progressive renal failure. The primary cilium, a sensory organelle essential for cellu...
A Case of Horseshoe Kidney and Autosomal Dominant Polycystic Kidney Disease with PKD1 Gene Mutation [0.03%]
一例PKD1基因突变引起的马蹄肾合并常染色体显性多囊肾病患者报告
Hyeongwan Kim,Soo Jin Lee,Won Kim
Hyeongwan Kim
Because polycystic kidney disease has various causes, genetic testing is essential for the diagnosis of autosomal dominant polycystic kidney disease (ADPKD) in patients with polycystic horseshoe kidney disease.
Effects of Pregnancy on Liver and Kidney Cyst Growth Rates in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study [0.03%]
妊娠对常染色体显性多囊肾病患者肝肾囊肿生长速度影响的初步研究
Vahid Bazojoo,Vahid Davoudi,Jon D Blumenfeld et al.
Vahid Bazojoo et al.
Background/Objectives: Polycystic liver disease (PLD) is the most common extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD). PLD is more prevalent in women, and women have larger liver cysts, possibly due to estrogen-related mechanisms.
Beyza Doğan,Fatih Ergül,Mikail Dağ et al.
Beyza Doğan et al.
The predominant underlying conditions were diabetes mellitus (58.8%), hypertension (29.4%), and polycystic kidney disease (11.8%).
Is There a Future for SGLT2 Therapy to Treat Kidney Failure in US Veterans Living with Autosomal Dominant Polycystic Kidney Disease? [0.03%]
SGLT2疗法能否治疗美国退伍军人中常染色体显性多囊肾病患者的肾脏衰竭？
Brittany Dickerson
Brittany Dickerson
Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction [0.03%]
多囊蛋白通道孔螺旋中的致病突变导致不同的通道功能障碍形式
Orhi Esarte Palomero,Eduardo Guadarrama,Paul G DeCaen
Orhi Esarte Palomero
Millions of individuals carry pathogenic genetic variants in PKD2 that cause a life-threatening condition called autosomal dominant polycystic kidney disease (ADPKD).
Kidney cystogenesis in embryonic- and adult-onset ADPKD is suppressed from lack of adenylyl cyclase targeting to cilia [0.03%]
胚胎期和成人期发生的常染色体显性多囊肾病的肾脏囊肿发生由于腺苷酸环化酶定位到纤毛受阻而被抑制
Sun-Hee Hwang,Kyungsuk Choi,Hemant Badgandi et al.
Sun-Hee Hwang et al.
Multiple cellular pathways are dysregulated in autosomal dominant polycystic kidney disease (ADPKD), but mechanisms initiating cyst formation are unknown. ADPKD is caused by mutations in Pkd1/Pkd2 genes that encode for polycystins that localize to primary cilia.
Procalcitonin levels at hospital admission are increased in cyst infection in patients with autosomal dominant polycystic kidney disease [0.03%]
囊性肾病患者的医院入学前列腺素水平升高
Jihad Abdelmalki,Laurence Seidel,Frédéric Frippiat et al.
Jihad Abdelmalki et al.
Introduction: The diagnosis of cyst infection in autosomal dominant polycystic kidney disease (ADPKD) is difficult. [18F]FDG PET/CT imaging is helpful, but early diagnosis remains challenging.
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