S100A8 Mediates Autophagy and Apoptosis in Ovarian Cancer Cells via the PI3K/Akt Pathway [0.03%]
S100A8通过PI3K/Akt途径介导卵巢癌细胞的自噬和凋亡
Xiaojie Ma,Yu Wu,Guanyu Cao
Xiaojie Ma
Background: Ovarian cancer (OC) is one of the most lethal forms of gynecological malignancies. Previous studies indicate that S100 calcium-binding protein A8 (S100A8) regulation of the phosphoinositide 3-kinase/protein ki...
Combined Oral Contraceptives Modulate Apoptosis via IL-11/PI3K/AKT Pathway in Rat With Premature Ovarian Insufficiency [0.03%]
复方口服避孕药通过IL-11/PI3K/AKT途径调节早发性卵巢功能不全大鼠卵泡凋亡
Meiling Chen,Fan Zhang,Fang You et al.
Meiling Chen et al.
Background: Premature ovarian insufficiency (POI) is characterized by a reduction in primary follicle count along with abnormal follicle development. This study aims to explore the impact of combined oral contraceptives (...
Bioactive Fraction of Processed Curcumae Rhizoma-Sparganii Rhizoma Anti-liver Fibrosis by Regulate Taurine Metabolism through PI3K/AKT Pathway [0.03%]
炮姜黄-穿山甲抗肝纤维化通过调节牛磺酸代谢PI3K/AKT途径研究中的活性部位及作用机制
Min Hao,Ziyan Chen,Pingping Wang et al.
Min Hao et al.
Ethnopharmacological relevance: Fibrosis is a prevalent pathological process in various chronic liver conditions. Curcumae Rhizoma-Sparganii Rhizoma (CR-SR) and its vinegar-processed derivatives are representative traditi...
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function [0.03%]
六味地黄丸通过SIRT1/PI3K/AKT信号通路调节自噬和氧化应激改善卵巢功能的作用机制研究
Jiawen Zhong,Guoxia Lan,Xiaoqing Ma et al.
Jiawen Zhong et al.
Objective: This study aimed to examine the preventive impact of Liuwei Dihuang pill (LWDH) on ovarian injury and to elucidate its mechanism through in vivo and in vitro tests. ...
Protective Effects of Rosmarinic Acid Against Oxidative Damage and Atherosclerosis via the PI3K/AKT Pathway [0.03%]
鼠李糖酸通过PI3K/AKT途径抵御氧化损伤和动脉粥样硬化的作用机制研究
Tiantian Tang,Mingze Sun,Baiyuan Sha et al.
Tiantian Tang et al.
Rosmarinic acid (RosA), a water-soluble phenolic compound, was recognized as a healthy and effective agent in antioxidant and anti-cardiovascular disease therapy. In vitro, RosA inhibited the adverse effects of H2O2 on HUVEC cells, which re...
Xiaojianzhong decoction inhibits gastric cancer progression and enhances 5-Fu efficacy by regulating the MAPK and PI3K-AKT signaling pathway [0.03%]
小建中汤通过调节MAPK和PI3K-Akt信号通路抑制胃癌进展并增敏氟尿嘧啶作用
Yanxue Xu,Yumeng Zhang,Chen Huang et al.
Yanxue Xu et al.
Aim of the study: This study aims to investigate the pharmacological mechanisms underlying the enhancement of fluorouracil (5-Fu) efficacy by Xiaojianzhong decoction (XJZD) in the treatment of gastric cancer (GC). ...
Mutational analysis and protein expression of PI3K/AKT pathway in four mucinous cystadenocarcinoma of the breast [0.03%]
PI3K/AKT途径的突变分析及四种乳腺黏液性囊腺癌的蛋白质表达
Yan Zheng,Huaxiao Tang,Qian Liu et al.
Yan Zheng et al.
Introduction: Primary mucinous cystadenocarcinoma of the breast (BMCA) is a rare neoplasm with few reports in the literature. Its molecular characteristics, prognosis, and treatment protocols are not well understood, and ...
Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4 [0.03%]
E2F1通过MCM4激活PI3K/AKT途径促进非小细胞肺癌进展
Yuyin Cai,Xinyan Lu,Tingting Li et al.
Yuyin Cai et al.
Purpose: Among malignant tumors, non-small cell lung cancer (NSCLC) remains a major threat to human life and health. Studies have illustrated that minichromosome maintenance protein 4 (MCM4) has complex interactions with ...
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway [0.03%]
巴马汀衍生物B-9-3通过VEGFA/PI3K/AKT信号途径抑制非小细胞肺癌
Yuche Wu,Bing Wang,Xuwen Mao et al.
Yuche Wu et al.
Background: This study aimed to investigate the molecular mechanism by which the Harmine derivative B-9-3 inhibits angiogenesis and promotes apoptosis in non-small cell lung cancer (NSCLC). ...
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation [0.03%]
Podophyllotoxin通过激活PI3K / AKT信号通路缓解DSS诱导的溃疡性结肠炎
T Li,X Wang,J Wang
T Li
This study systematically evaluated the therapeutic effects of podophyllotoxin in a DSS-induced mouse model of ulcerative colitis. A total of 374 podophyllotoxin-related targets were identified through database screening, and by intersectin...
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