Management Practices for Raynaud Phenomenon in Patients With Systemic Sclerosis: A Real-World Data From Community-Based Practices in the United States [0.03%]
美国社区实践中的系统性硬化症患者的雷诺现象管理方法：基于真实世界的数据研究
Gulsen Ozen,Sofia Pedro,Robyn T Domsic et al.
Gulsen Ozen et al.
The use of RP medications persistently (29%), combination regimens (20%), and advanced therapies (15%; phosphodiesterase-5 inhibitors [PDE5i], endothelin receptor antagonists, or prostaglandin analogs) throughout the follow-up was low.
Therapeutic Challenges of Diabetes Mellitus-Related Erectile Dysfunction and The Potential Therapeutic Role of Medicinal Plants: A Narrative Review [0.03%]
糖尿病相关勃起功能障碍的治疗挑战及药用植物的潜在治疗作用：叙述性综述
Hao Wang,Hongyuan Chang,Di Sun et al.
Hao Wang et al.
The efficacy of oral phosphodiesterase-5 inhibitors is often ineffective in DMED and there is a need to search for effective drugs. Medicinal plants such as Eucommia ulmoides Oliv. Leaf, Cordycep militaris have been used in treating DMED in some experiments.
Pharmacotherapy for BPH-related LUTS: associations between medication patterns, persistence, and treatment failure [0.03%]
BPH相关性LUTS的药物治疗：用药模式、持续时间与治疗失败的关系分析
Takeshi Soda,Tomohide Yamauchi,Hikari Otsuka et al.
Takeshi Soda et al.
Methods: We reviewed the medical charts of 779 patients who initiated pharmacotherapy with α-blockers (ABs), 5α-reductase inhibitors (5ARIs), or phosphodiesterase-5 inhibitors (PDE5Is) between January 2014 and December 2021.
Efficacy of the combination of tadalafil and tamsulosin versus tadalafil alone as a medical expulsive therapy for stone L1/3 ureter 10 mm or less: A prospective comparative placebo-controlled study [0.03%]
他达拉非联合坦索罗辛治疗输尿管下段(第L1/L3节段)小于等于10mm结石的排石效果优于单用他达拉非：一项前瞻性的假对照研究
Ahmed Reda,Mostafa Kamel,Mohamed Loay et al.
Ahmed Reda et al.
Many drugs, including phosphodiesterase-5 inhibitors (PDE5Is) and α-blockers, are used to relax the smooth muscles in medical expulsive therapy (MET).
Efficacy and safety of 2% isosorbide cream in systemic sclerosis patients with digital ulcers and Raynaud's phenomenon [0.03%]
2%异山梨酯霜治疗系统性硬化症患者的数字溃疡和雷诺现象的有效性和安全性
Suwassa Namvijit,Chingching Foocharoen,Siraphop Suwannaroj et al.
Suwassa Namvijit et al.
Calcium channel blockers (CCBs) and phosphodiesterase-5 inhibitors (PDE-5i) have been used to improve blood flow. However, vasodilators are limited in patients with low blood pressure.
Management of Pulmonary Arterial Hypertension: Current Strategies and Future Prospects [0.03%]
肺动脉高压的管理：当前策略与未来展望
Munish Sharma,Vivek Paudyal,Saifullah Khalid Syed et al.
Munish Sharma et al.
Current therapies are categorized based on targeting different pathways known to contribute to PAH, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 inhibitors (PDE-5 inhibitors), prostacyclin analogs, soluble guanylate cyclase stimulators, and activin signaling inhibitors such as
The effect of topical and intraurethral alprostadil on erectile function: A systematic review and meta-analysis [0.03%]
尿道局部应用前列腺素对男性勃起功能的影响：系统评价和荟萃分析
Iason Papadopoulos,Maksim Tishukov,Ioannis Sokolakis et al.
Iason Papadopoulos et al.
While phosphodiesterase-5 inhibitors (PDE5i) are the first line of medical treatment, they are not always effective. Alprostadil, available in injectable, topical, and intraurethral forms, offers an alternative treatment modality.
Prescription patterns demonstrate high demand for treating erectile dysfunction following radical prostatectomy [0.03%]
根治性前列腺切除术后治疗勃起功能障碍的处方模式表现出极高的需求
Signe Benzon Larsen,Annika Von Heymann,Hein V Stroomberg et al.
Signe Benzon Larsen et al.
Background and purpose: Radical prostatectomy can cause erectile dysfunction; however, subsequent treatment with, e.g., phosphodiesterase-5 inhibitors may improve sexual function in the patients.
Epidemiology, Natural History, Humanistic and Economic Burden of Pulmonary Arterial Hypertension in China: A Systematic Literature Review [0.03%]
中国的肺动脉高压流行病学、自然史以及人文和经济负担的系统文献回顾
Caojin Zhang,Helen Ding,Jiahe Li et al.
Caojin Zhang et al.
For PAH-targeted therapy, monotherapy (primarily phosphodiesterase-5 inhibitors and endothelin receptor antagonists) was prescribed more often than combination therapies. 36-Item Short Form Survey (SF-36) was the most utilized HRQoL instrument.
Molecular Dynamics-Assisted Discovery of Novel Phosphodiesterase-5 Inhibitors Targeting a Unique Allosteric Pocket [0.03%]
基于分子动力学的新型磷酸二酯酶-5 allosteric抑制剂的研究与发展
Weihao Luo,Runduo Liu,Xinlin Cai et al.
Weihao Luo et al.
Phosphodiesterase-5 (PDE5) is a potent therapeutic target for the treatment of male erectile dysfunction and pulmonary arterial hypertension with several drugs available on the market. However, most of the reported PDE5 inhibitors lack spec...
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