Mirodenafil improves cognitive function by reducing microglial activation and blood-brain barrier permeability in ApoE4 KI mice [0.03%]
米罗丹菲通过减少小胶质细胞活化和APOE4转基因小鼠血脑屏障通透性改善认知功能
Yejin Park,Subin Moon,Harry Jung et al.
Yejin Park et al.
Mirodenafil, a potent and selective phosphodiesterase 5 inhibitor (PDE5i), was orally administered to ApoE4 KI mice for 4 weeks.
Phosphodiesterase 5 Inhibitor Improves Insulin Sensitivity by Regulating Adipose Tissue Macrophage Polarization in Diet-Induced Obese Mice [0.03%]
磷酸二酯酶5抑制剂通过调节饮食诱导的肥胖小鼠脂肪组织巨噬细胞极化来改善胰岛素敏感性
Dan-Gyeong Song,Seongwon Pak,Dae-Chul Shin et al.
Dan-Gyeong Song et al.
Background: Obesity is a rapidly increasing global health issue, which is associated with glucose and insulin resistance. Phosphodiesterase type 5 (PDE5) inhibitors (PDE5i) are known for their ability to enhance blood flo...
Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi [0.03%]
维生素D缺乏诱导的勃起功能障碍：超氧阴离子和Slpi的作用
Miguel A Olivencia,Belén Climent,Bianca Barreira et al.
Miguel A Olivencia et al.
This ED was also reproduced in vitamin D-deficient rats and VDR knockout mice, in vivo and ex vivo, and is associated with penile fibrosis and reduced response to the phosphodiesterase 5 inhibitor (PDE5i) sildenafil.
Revisiting experimental models of erectile dysfunction and their value in drug discovery and development [0.03%]
阳痿的实验模型的再探讨及其在药物研发中的价值
Hao Wang,Eric Chung
Hao Wang
However, focusing on drug development for those types of ED where phosphodiesterase 5 inhibitor therapy is limited may be more valuable.
Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription [0.03%]
一种用于预防胃癌生长的磷酸二酯酶-5抑制剂西地那非的再利用可通过抑制c-MYC稳定性和白介素-6转录发挥作用
Zhenzhan Zhang,Wuqing Huang,Donghua Huang et al.
Zhenzhan Zhang et al.
Phosphodiesterase-5 (PDE5) inhibitors have shown promise as anti-cancer agents in malignancies. However, their specific effects on gastric cancer (GC) and the underlying mechanisms remain elusive. Our aim was to investigate this by combinin...
Vitamin D as an add-on therapy to phosphodiesterase-5 inhibitor in experimental pulmonary arterial hypertension [0.03%]
维生素D作为实验性肺动脉高压磷酸二酯酶-5抑制剂附加疗法的研究
Rui Adão,Bianca Barreira,Elena Paternoster et al.
Rui Adão et al.
Severe vitamin D (vitD) deficiency is a very common condition in patients with pulmonary arterial hypertension (PAH) and it is predictor of poor prognosis. There is emerging evidence suggesting a connection between the insufficient response...
A novel phosphodiesterase 5 inhibitor, RF26, improves memory impairment and ameliorates tau aggregation and neuroinflammation in the P301S tauopathy mouse model of Alzheimer's disease [0.03%]
一种新型磷酸二酯酶5抑制剂RF26改善P301Stauopathy阿尔茨海默病小鼠模型的认知障碍和tau蛋白聚集及神经炎症
Sara El-Desouky,Mohammad Abdel-Halim,Reem K Fathalla et al.
Sara El-Desouky et al.
Phosphodiesterase-5 (PDE5) inhibitors are primarily used in the treatment of erectile dysfunction and pulmonary hypertension, but have also been reported to have a potential therapeutic effect for the treatment of Alzheimer's disease (AD). ...
Influence of personality disorders on sexual behaviours and response to treatment of psychogenic erectile dysfunction in phosphodiesterase 5 inhibitor non-responders [0.03%]
人格障碍对心理性勃起功能障碍患者性行为及磷酸二酯酶5抑制剂治疗反应的影响
Marina Cabello-García,Yolanda Sánchez-Sandoval,Antonio Daniel García-Rojas
Marina Cabello-García
Background: Personality disorders may influence sexual behaviours and sexual dysfunction. Aim: Our main objective was to analyse the in...
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1 [0.03%]
药理学上增加一氧化氮-camp反应蛋白稳态并减少CMT1模型小鼠的神经病症状
Seth M Moore,Joseph Gawron,Mckayla Stevens et al.
Seth M Moore et al.
Here we increased cGMP in the S63del mouse model of CMT1B by treating for three weeks with either the phosphodiesterase 5 inhibitor tadalafil, or the brain-penetrant soluble guanylyl cyclase stimulator CYR119.
Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats [0.03%]
米罗达非，一种磷odiester酶5抑制剂，对脑卒中模型大鼠的治疗作用
Fred Kim,Padmanabh Singh,Hyunji Jo et al.
Fred Kim et al.
Mirodenafil is a phosphodiesterase 5 (PDE5) inhibitor with high specificity for its target and good blood-brain barrier permeability. The drug, which is currently used for treatment of erectile dysfunction, reduces Aβ and pTau levels and i...
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