Pharmacological Strategies for the Management of Severe Alcohol-associated Hepatitis: A Systematic Review and Meta-analysis [0.03%]
严重酒精性肝炎的药理学策略：系统评价和 meta 分析
Alvi H Islam,Claudia Alvizuri,Hailemichael Desalegn et al.
Alvi H Islam et al.
The aim of this systematic review was to determine the optimal pharmacological treatment for severe AH that results in better survival outcomes.
Recommendations issued by clinical practice guidelines for the implementation of healthy lifestyles in adult patients diagnosed with gout: a scoping review [0.03%]
成人痛风患者健康生活方式指导规范推荐的实施情况：系统评价
Diego S Morales-Gonzales,Arihana A Paredes-Valdiviezo,Mariano Gallo Ruelas et al.
Diego S Morales-Gonzales et al.
Although pharmacological treatment is key, lifestyle changes can help in its prevention and control.
VU0810464, a selective GIRK channel activator, improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers [0.03%]
VU0810464，一种选择性的GIRK通道激活剂，可改善淀粉样蛋白-寡聚体破坏的海马区依赖性突触可塑性和记忆功能
Jaime Mulero-Franco,Raquel Jimenez-Herrera,Ana Contreras et al.
Jaime Mulero-Franco et al.
Therefore, GIRK-based pharmacological treatment needs further investigation to overcome these limitations. Here we tested two doses of a novel, more potent, and neuronal selective GIRK activator, VU0810464, in healthy and intracerebroventricular (icv.) oAβ1-42-induced AD-like male and female mice.
Fibrogenic Gene Signature as Early Prediction for the Efficacy of Pharmacological Interventions for MASH-Associated Fibrosis [0.03%]
药物干预治疗MASH相关纤维化的疗效早期预测的纤维化基因特征signature
José A Inia,Martine C Morrison,Arianne van Koppen et al.
José A Inia et al.
The incidence of metabolic dysfunction-associated steatohepatitis (MASH) and associated liver fibrosis is rapidly increasing, while pharmacological treatment options remain limited.
Lorenzo Zamboni,Francesca Fusina,Rebecca Casari et al.
Lorenzo Zamboni et al.
Additionally, pharmacological treatment for ADHD appears to be effective and well-tolerated in KS patients, with minimal side effects.
Seed Cycling and Hormonal Balance: A Case Study of Successful Fertility Intervention in Polycystic Ovarian Syndrome [0.03%]
种子循环与激素平衡：多囊卵巢综合征生育干预的成功案例研究
Puja Dhamija,Akash More,Namrata Choudhary et al.
Puja Dhamija et al.
This case highlights the effectiveness of integrating pharmacological treatment with seed cycling to improve fertility outcomes in patients with PCOS.
Clinical efficacy of non-pharmacological treatment of functional constipation: a systematic review and network meta-analysis [0.03%]
非药理性治疗功能性便秘临床疗效的系统评价和网络 meta 分析
Shufa Tan,Chengtao Peng,Xin Lin et al.
Shufa Tan et al.
Introduction: The purpose of this study is to compare the relative effectiveness and safety of non-pharmacological interventions for the treatment of functional constipation (FC). ...
Microbiome Engineering for Biotherapeutic in Alzheimer's Disease Through the Gut-Brain Axis: Potentials and Limitations [0.03%]
肠道菌群工程通过肠脑轴用于阿尔茨海默病生物治疗的潜力与局限性
Editha Renesteen,Jacqueline L Boyajian,Paromita Islam et al.
Editha Renesteen et al.
Despite its current pharmacological treatment for AD, different approaches to treat such disease are being developed, from a microbiome perspective. The microbiome encompasses a diverse microorganism, including beneficial bacteria that create a positive impact to diminish AD pathogenesis.
Cancer network pharmacology: multi-network regulatory mechanisms and future directions [0.03%]
癌症网络药理学：多网络调控机制与未来展望
Zixuan Zhao,Jiahan Le,Zhenjie Fu et al.
Zixuan Zhao et al.
This review aims to clarify the application of network pharmacology in exploring the pharmacological treatment mechanism of natural products, drug repositioning, and new technology combinations in the context of complex pathogenesis of cancer, so as to help realize the full potential of network pharmacology
Deep brain stimulation improves symptoms across all dimensions in treatment-resistant depression [0.03%]
深部脑刺激可改善难治性抑郁症的所有维度的症状
N Runia,G J J Mol,D A J P Denys et al.
N Runia et al.
Our findings demonstrate that DBS for TRD effectively treats depressive symptoms in all dimensions, although insomnia symptoms may improve at a slower rate, and that patients with more anxiety symptoms, who typically tend to have worse pharmacological treatment outcomes, may particularly benefit from
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