A Core Physiologically Based Toxicokinetic (PBTK) Model for Exposure Assessment of Multiple Environmental Phenols [0.03%]
环境酚类物质暴露评估核心生理基于毒性动力学(PBTK)模型
Jeong Weon Choi,Seungho Lee,Jangwoo Lee et al.
Jeong Weon Choi et al.
Environmental phenols are widely used in consumer products and are of increasing concern due to their potential endocrine-disrupting effects. Physiologically based toxicokinetic (PBTK) models offer a powerful tool for estimating human expos...
Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model [0.03%]
女性卫生用品中挥发性有机化合物(Vocs)的经皮暴露估算：结合测量数据和基于生理的毒物动力学(PBTK)模型
Nan Lin,Zengwei Li,Ning Ding et al.
Nan Lin et al.
Background: Increasing studies have informed noteworthy health risks associated with dermal exposure to volatile organic compounds (VOCs) from feminine hygiene products (FHPs). ...
Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans [0.03%]
基于生理的毒代动力学（PBTK）模型的研发及在赭曲霉毒素A(OTA)大鼠和人毒性预测中的应用
Bu-Da Su,Xiao-Meng Li,Zhi-Wei Huang et al.
Bu-Da Su et al.
Ochratoxin A (OTA) is a common fungal toxin frequently detected in food and human plasma samples. Currently, the physiologically based toxicokinetic (PBTK) model plays an active role in dose translation and can improve and enhance the risk ...
Bioconcentration of polycyclic aromatic hydrocarbons in different tissues of zebrafish (Danio rerio) investigated with PBTK model [0.03%]
用药物动力学模型研究不同组织中斑马鱼的多环芳烃生物积累性
Yawei Zhai,Haotian Wang,Xiaohan Lin et al.
Yawei Zhai et al.
Due to the lipophilicity, polycyclic aromatic hydrocarbons (PAHs) are easily accumulated in fish. However, the research on PAH bioaccumulation process in different fish tissues and the relevant effect mechanisms are still deficient. The bio...
In vitro to in vivo extrapolation for predicting human equivalent dose of phenolic endocrine disrupting chemicals: PBTK model development, biological pathways, outcomes and performance [0.03%]
体内体外推算用于预测酚类内分泌干扰化学物的人类等效剂量：生理基底毒性模型研发、生物途径、结果与表现
Ruili Xie,Xiaodan Wang,Yiping Xu et al.
Ruili Xie et al.
In vitro to in vivo (IVIVE) leverages in vitro high-throughput biological responses to predict the corresponding in vivo exposures and further estimate the human safe dose. However, for phenolic endocrine disrupting chemicals (EDCs) linked ...
Estimation of the bio-accessibility of methylmercury from aquatic foods using a PBTK model with an approximate Bayesian computation method in Chinese pregnant women [0.03%]
使用简化贝叶斯计算方法的体内动力学模型对中国孕妇从水产品摄入甲基汞生物可给性的评估研究
Yuan-Shen Zhu,Jia-Qi Yang,Na Wang et al.
Yuan-Shen Zhu et al.
Background: Fish are the primary source of protein and docosahexaenoic acid (DHA) for pregnant women and children, but methylmercury (MeHg) pollution is the potential hazard of fish consumption. In risk assessments, the b...
The toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model [0.03%]
采用生理基于结构毒性动力学模型阐明双酚A及其代谢产物在鱼体内的毒性动力学行为
Corentin Mit,Anne Bado-Nilles,Gaëlle Daniele et al.
Corentin Mit et al.
Bisphenol A (BPA) is a chemical of major concern due to its endocrine disrupting function, high production volume, and persistence in the aquatic environment. Consequently, organisms such as fish are subject to chronic exposure to BPA. Howe...
Liver-Based Probabilistic Risk Assessment of Exposure to Organophosphate Esters via Dust Ingestion Using a Physiologically Based Toxicokinetic (PBTK) Model [0.03%]
基于生理毒代动力学(PBTK)模型的经灰尘摄入暴露于磷酸酯的肝脏概率风险评估研究
Jiaqi Ding,Wenxin Liu,Hong Zhang et al.
Jiaqi Ding et al.
Organophosphate esters (OPEs) are widely used and harmful to organisms and human health. Dust ingestion is an important exposure route for OPEs to humans. In this study, by integrating ToxCast high-throughput in vitro assays with in vitro t...
A generic PBTK model implemented in the MCRA platform: Predictive performance and uses in risk assessment of chemicals [0.03%]
基于MCRA平台的通用PBTK模型及其在化学物质风险评估中的应用研究
Cleo Tebby,Hilko van der Voet,Georges de Sousa et al.
Cleo Tebby et al.
Physiologically-based toxicokinetic (PBTK) models are important tools for in vitro to in vivo or inter-species extrapolations in health risk assessment of foodborne and non-foodborne chemicals. Here we present a generic PBTK model implement...
PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data [0.03%]
基于人体生物监测和毒物动力学数据的卤氟吡氧乙酸操作者暴露风险的PBTK模型评估
Alexander B Cooper,Manoj Aggarwal,Michael J Bartels et al.
Alexander B Cooper et al.
Physiologically-based toxicokinetic (PBTK) models are mathematical representations of chemical absorption, distribution, metabolism and excretion (ADME) in animals. Each parameter in a PBTK model describes a physiological, physicochemical o...
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