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Guofeng Shi,Shuanghe Wang,Shanshan Luo et al. Guofeng Shi et al.
To establish a p-chlorophenylalanine (PCPA)-induced insomnia model in mice, the levels of GAD65, GABAARα1, 5HT-2A, and 5HT-1A were detected by immunohistochemistry. The normal neurons in the mouse brain were counted by Nissl staining.
Quntao Li,Jingwen Zhai,Tongyu Du et al. Quntao Li et al.
Methods: Insomnia models were established by intraperitoneal injection of 400 mg/kg p-chlorophenylalanine (PCPA) in SD rats. FAM was administered at three doses: 10, 20, and 40 mg/kg. Anxiety levels were assessed using the elevated plus maze and open field tests.
I Erkizia-Santamaría,N Martínez-Álvarez,L Salinas-Novoa et al. I Erkizia-Santamaría et al.
Conversely, depletion of 5-HT by p-chlorophenylalanine potentiated psilocybin-evoked HTR.
Lijuan Yan,Xiao Wang,Xiang Liu et al. Lijuan Yan et al.
Methods and analysis: The study will use glutamate (Glu) concentrations of p-chlorophenylalanine (PCPA) -induced insomnia rat model to examine whether EA at specific acupoints can increase GABA levels in the brain and plasma by enhancing the abundance of GABA-producing gut bacteria
Chunyuan Ren,Tong Cheng,Jingrui Jia et al. Chunyuan Ren et al.
However, p-chlorophenylalanine inhibited the synthesis of melatonin and eliminated the effect of tryptophan.
Lijing Zhang,Ya Zhao,Hao Chen et al. Lijing Zhang et al.
We employed an array of methodologies, including in vivo experiments involving the assessment of the impacts of PA on sleep behavior in a p-chlorophenylalanine (PCPA)-induced insomnia mouse model, and the detection of neurotransmitters, inflammatory factors, and hypothalamic-pituitary-adrenal (HPA) axis-related
Yiyang Zhao,Runchen Fang,Hongsheng Bian et al. Yiyang Zhao et al.
This study compares three sleep deprivation models-Modified Multiple Platform Method (MMPM), treadmill method, and p-chlorophenylalanine (PCPA) method-on key physiological, cognitive, and emotional parameters in male Sprague-Dawley rats.
Dan Wen,Ning Yang,Wenjun Zhang et al. Dan Wen et al.
To determine the interrelation between abscisic acid and melatonin in selenite alleviating cold stress, abscisic acid inhibitor fluridone and melatonin synthesis inhibitor p-chlorophenylalanine were used for in-depth study.
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