Research on the Improvement Effects and Mechanisms of Magnolia sieboldii Essential Oils on Insomnia in Mice [0.03%]
Magnolia sieboldii芳香水汽吸入改善小鼠失眠的作用及机制研究
Guofeng Shi,Shuanghe Wang,Shanshan Luo et al.
Guofeng Shi et al.
To establish a p-chlorophenylalanine (PCPA)-induced insomnia model in mice, the levels of GAD65, GABAARα1, 5HT-2A, and 5HT-1A were detected by immunohistochemistry. The normal neurons in the mouse brain were counted by Nissl staining.
Ferulic acid methylester improves the comorbidity of insomnia and anxiety in a rat model of PCPA-induced sleep disorder by activating DRN 5-HT neurons [0.03%]
牻牛儿醇甲酯通过激活DRN 5-ht神经元改善PCPA诱导的失眠共病焦虑小鼠模型的行为学症状研究
Quntao Li,Jingwen Zhai,Tongyu Du et al.
Quntao Li et al.
Methods: Insomnia models were established by intraperitoneal injection of 400 mg/kg p-chlorophenylalanine (PCPA) in SD rats. FAM was administered at three doses: 10, 20, and 40 mg/kg. Anxiety levels were assessed using the elevated plus maze and open field tests.
Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice [0.03%]
裸头鬼笔素的致幻作用与内源性血清素的关系研究
I Erkizia-Santamaría,N Martínez-Álvarez,L Salinas-Novoa et al.
I Erkizia-Santamaría et al.
Conversely, depletion of 5-HT by p-chlorophenylalanine potentiated psilocybin-evoked HTR.
An analysis of electroacupuncture as adjunctive treatment for insomnia: a new perspective targeting GABA-mediated microbiome-gut-brain axis [0.03%]
从靶向GABA介导的微生态-肠脑轴角度分析电针治疗失眠的新思路
Lijuan Yan,Xiao Wang,Xiang Liu et al.
Lijuan Yan et al.
Methods and analysis: The study will use glutamate (Glu) concentrations of p-chlorophenylalanine (PCPA) -induced insomnia rat model to examine whether EA at specific acupoints can increase GABA levels in the brain and plasma by enhancing the abundance of GABA-producing gut bacteria
Exogenous tryptophan enhances cold resistance of soybean seedlings by promoting melatonin biosynthesis [0.03%]
外源色氨酸通过促进松果体素生物合成提高大豆幼苗抗寒性
Chunyuan Ren,Tong Cheng,Jingrui Jia et al.
Chunyuan Ren et al.
However, p-chlorophenylalanine inhibited the synthesis of melatonin and eliminated the effect of tryptophan.
Parishin A alleviates insomnia by regulating hypothalamic-pituitary-adrenal axis homeostasis and directly targeting orexin receptor OX2 [0.03%]
Parishin A通过调节下丘脑-垂体-肾上腺轴稳态和直接作用于食欲肽受体OX2来缓解失眠
Lijing Zhang,Ya Zhao,Hao Chen et al.
Lijing Zhang et al.
We employed an array of methodologies, including in vivo experiments involving the assessment of the impacts of PA on sleep behavior in a p-chlorophenylalanine (PCPA)-induced insomnia mouse model, and the detection of neurotransmitters, inflammatory factors, and hypothalamic-pituitary-adrenal (HPA) axis-related
Comparative analysis of sleep deprivation models: Impacts on sleep architecture, emotional state, cognitive function, and biochemical indicators in male rats [0.03%]
睡眠剥夺模型的比较分析及其对雄性大鼠睡眠结构、情绪状态、认知功能和生化指标的影响
Yiyang Zhao,Runchen Fang,Hongsheng Bian et al.
Yiyang Zhao et al.
This study compares three sleep deprivation models-Modified Multiple Platform Method (MMPM), treadmill method, and p-chlorophenylalanine (PCPA) method-on key physiological, cognitive, and emotional parameters in male Sprague-Dawley rats.
GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L [0.03%]
硒通过调节铁的吸收和分布参与冷胁迫下ABA上游信号GATA3-COMT1-松果菊素代谢通路的研究——以黄瓜为材料
Dan Wen,Ning Yang,Wenjun Zhang et al.
Dan Wen et al.
To determine the interrelation between abscisic acid and melatonin in selenite alleviating cold stress, abscisic acid inhibitor fluridone and melatonin synthesis inhibitor p-chlorophenylalanine were used for in-depth study.
Exogenous melatonin alleviates nicosulfuron toxicity by regulating the growth, photosynthetic capacity, and antioxidative defense of sweet corn seedlings [0.03%]
外源褪黑素通过调节甜玉米幼苗的生长、光合作用和抗氧化防御缓解硝磺草酮毒害作用
J X Huang,Y B Liu,R Xiao et al.
J X Huang et al.
The inhibition of p-chlorophenylalanine inhibited the positive effects of MT on photosynthetic and physiological indexes.
Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats [0.03%]
异 bicyclogermacrenal改善睡眠剥夺引起的大鼠海马神经化学异常和神经炎症介导的铁死亡参与
Ao Yan,Zhejin Li,Yuanwei Gao et al.
Ao Yan et al.
Methods: In this study, IG was extracted and characterized from Valeriana officinalis, and an SLD model was established in rats using p-chlorophenylalanine (PCPA).
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