Augmentation of Infrared Microscopy of White Blood Cells and Medical Measures for Rapid and Accurate Diagnosis of Bacterial or Viral Infections in Febrile Pediatric Oncology Patients: An Expert System-Based Study [0.03%]
基于专家系统对发热儿科肿瘤患者的细菌或病毒感染的快速准确诊断的白细胞红外显微镜增强和医疗措施：一项基于专家系统的研究
Uraib Sharaha,Yotam D Eshel,Dima Bykhovsky et al.
Uraib Sharaha et al.
Current diagnostic procedures require 2-4 days, prompting physicians to rely on clinical measures like C-reactive protein (CRP), white blood cell (WBC) count, and absolute neutrophil count (ANC) despite their limited specificity, leading to unnecessary antibiotic treatment.
Tumor-associated neutrophils and neutrophil extracellular traps in lung cancer: antitumor/protumor insights and therapeutic implications [0.03%]
肺癌相关的肿瘤相关中性粒细胞和中性粒细胞胞外陷阱：抗肿瘤/促肿瘤作用及治疗意义
Milad Sheervalilou,Mostafa Ghanei,Masoud Arabfard
Milad Sheervalilou
Among the immune components of the TME, tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs) have garnered increasing attention due to their complex and sometimes contrasting roles in tumor biology.
Neutrophil-Lymphocyte Ratio and LDH/Albumin Ratio as Biomarkers for Severity and Mortality in Acute Pancreatitis [0.03%]
中性粒细胞淋巴细胞比值和乳酸脱氢酶/白蛋白比值作为急性胰腺炎严重程度及预后的生物标志物研究
Göksel Bengi,İbrahim Çelik,Süleyman Dolu et al.
Göksel Bengi et al.
Background/aims: Acute pancreatitis (AP) is a common and potentially severe condition, and early identification of its severity is critical for appropriate clinical management. This study aimed to investigate the role of ...
IFN-I-mediated neutropoiesis bias drives neutrophil priming and inflammatory comorbidities [0.03%]
干扰素I介导的中性粒细胞谱系偏向诱导了炎性并发症中的中性粒细胞易激惹现象
Yuman Li,Yiming Chen,Chenyu Deng et al.
Yuman Li et al.
Differentiation trajectories and key transcription factors (TFs) governing neutrophil lineage commitment were identified. Neutrophil priming was assessed using Smart-seq2, bulk RNA-seq, and lipopolysaccharide stimulation assays....Results: Transcriptional and chromatin accessibility profiling demonstrated that LIP induces a selective skewing of HSPC differentiation toward the neutrophil lineage. This reprogramming results in sustained expansion of primed neutrophils, which contribute to the aggravation of distal arthritis....Rarg and Nr2f6 were identified as potential TFs contributing to IFN-I-mediated neutrophil lineage commitment. Notably, resolution of periodontitis reversed the hematopoietic bias and mitigated arthritis progression.
Mannosylated neutrophil vesicles targeting macrophages alleviate liver inflammation by delivering CRISPR/Cas9 RNPs [0.03%]
甘露糖修饰的中性粒细胞囊泡通过递送CRISPR / Cas9 RNP靶向巨噬细胞从而缓解肝炎
Dongqing Wu,Hang Shu,Mengmeng Zhang et al.
Dongqing Wu et al.
Methods: We developed a novel delivery system by encapsulating CRISPR/Cas9 RNPs within mannosylated neutrophil membranes vesicles (Cas9/gNLRP3@M-N) to enhance targeting hepatic macrophages.
Biomarkers for pneumonia after major trauma: A systematic review and meta-analysis [0.03%]
重大创伤后肺炎生物标志物的系统评价和meta分析
Fiona Howroyd,Amanda Veiga Sardeli,Fang Gao Smith et al.
Fiona Howroyd et al.
During hospitalisation, patients with pneumonia had significantly higher IL-10 (4.42 (3.89-4.95), p > 0.001) and neutrophil oxidative burst capacity (1.52 (0.96-2.09), p > 0.001) at day 1, CYFRA21-1 at day 2 (0.43 (0.10-0.76), p = 0.01), IL-6 at day 3 (3.11 (2.66-3.55), p > 0.001) and day 5 (0.57 (0.05
Neutrophil Percentage-to-Albumin Ratio as a Prognostic Marker for Mortality in Ischemic Stroke Patients [0.03%]
中性粒细胞百分比-白蛋白比率可作为缺血性卒中患者的预后死亡标志物
Yue-Xin Lu,Bao-Jie Mao,Ming Wang et al.
Yue-Xin Lu et al.
Background: The neutrophil percentage-to-albumin ratio (NPAR) is an emerging inflammatory biomarker that has demonstrated a significant association with poor outcomes in patients with cardiovascular diseases....Receiver operating characteristic curves demonstrated that the NPAR provides a modestly greater ability to predict the risk of death in patients with IS compared to the individual indices of neutrophil percentage and albumin levels, although the specificity (0.567) and sensitivity (0.684) of NPAR were
Two Consecutive Days of Low-Dose Methotrexate Toxicity: A Diagnostic Challenge [0.03%]
小剂量甲氨蝶呤中毒的连续两天诊断挑战
Hridya Harimohan,Quynh Huynh,Mia Yasonova et al.
Hridya Harimohan et al.
Lab results revealed pancytopenia, with markedly low white blood cells, hemoglobin, platelets, and absolute neutrophil count. Initially, Stevens-Johnson Syndrome (SJS) was considered due to mucosal symptoms, but lack of rash made methotrexate toxicity more likely.
Case Reports
Cureus. 2025 Jun 14;17(6):e86023. DOI:10.7759/cureus.86023 2025
A nomogram model for prognosis of acute ischemic stroke treated with recombinant tissue-type plasminogen activator [0.03%]
rt-PA治疗急性缺血性卒中预后的Nomogram模型
Song Bai,Yan Liu,Chenggang Zhang et al.
Song Bai et al.
Keywords: acute ischemic stroke; neutrophil inflammatory index; nomogram model; prognosis; thrombolysis. Copyright © 2025 Bai, Liu, Zhang and Ren.
Association of neutrophil-percentage-to-albumin ratio with mortality in older stroke survivors [0.03%]
中性粒细胞百分比与老年脑卒中幸存者预后的关系
Jie Huang,Xiaowei Zhang,Luyao Ding et al.
Jie Huang et al.
Background: The neutrophil-percentage-to-albumin ratio (NPAR) functions as an integrative marker representing inflammatory response and nutritional health. However, its association with mortality in elderly stroke survivo...
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