FGFs/FGFRs and neuroinflammatory diseases: mechanism, drug therapies and delivery systems [0.03%]
FGFs/FGFRs与神经炎症性疾病：机制、药物治疗及递送系统
Juan Wang,Lijuan Xing,Song Yang et al.
Juan Wang et al.
Dysregulation of the FGFs/FGFRs system plays a key role in the progression of neurological diseases through the neuroinflammatory process. FGFs/FGFRs have become a key target of novel drugs in recent years for the treatment of neurological diseases.
Chuan Hong,Xiaopeng Liu,Zhou Zhou et al.
Chuan Hong et al.
Currently, compared to cancer and cardiovascular diseases, the roles and mechanisms of altered Tmod expression in neurological diseases remain poorly understood.
Roflumilast inhibits neuronal ferroptosis via AMPK/Nrf2/HO-1 signaling and promotes motor function recovery after spinal cord injury in rats [0.03%]
罗氟司特通过AMPK/Nrf2/HO-1信号通路抑制脊髓损伤后神经元铁死亡并促进运动功能恢复
YaoNan Han,XingTong Wang,DeShui Yu
YaoNan Han
Roflumilast has shown promising applications in the treatment of neurological diseases due to its potent anti-inflammatory and anti-oxidative stress effects. This study aimed to investigate whether roflumilast could inhibit neuronal ferroptosis to improve motor function after SCI in rats.
Zeyi Huang,Li Peng,Chunfu Zheng et al.
Zeyi Huang et al.
Abnormalities in the structure and function of neural circuits can disrupt normal physiological processes, leading to various disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), which are closely associated with dysfun...
Review: Human Intestinal Barrier-Optimal Measurement and Effects of Diet in the Absence of Overt Inflammation or Ulceration [0.03%]
review:肠道屏障功能的最优测量及其在无明显炎症或溃疡时饮食的影响
Michael Camilleri
Michael Camilleri
Results: Although many gastrointestinal, rheumatological, and degenerative neurological diseases are attributed to impaired intestinal barrier function, often termed "leaky gut," methods of accurate measurement of intestinal barrier function in vivo in humans are still being developed
The Role of the Ophthalmologist in the Prompt Diagnosis of Syphilis: Unmasking the Great Mimicker [0.03%]
眼科医生在梅毒早期诊断中的作用：揭开“伟大模仿者”的面纱
Luca De Simone,Francesca Ceccarelli,Pietro Gentile et al.
Luca De Simone et al.
Methods: We retrospectively reviewed four cases of ocular syphilis from 2022 to 2024, which were initially misdiagnosed as autoimmune or neurological diseases and thus inappropriately treated with immunosuppressive therapy.
Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases [0.03%]
单细胞转录组揭示神经疾病脑脊液免疫特征
David Ramos-Vicente,Paola Monterosso,Oriol de Fàbregues et al.
David Ramos-Vicente et al.
In this comprehensive review, we delve into the significant body of research on single-cell transcriptomics in cerebrospinal fluid (CSF) to understand neurological diseases with autoimmune, neurodegenerative, infectious, or oncogenic origins.
Imatinib attenuates neurobehavioral deficits and hippocampal neuronal damage after global cerebral ischemia in gerbils [0.03%]
伊马替尼减轻大脑全局缺血后沙鼠的神经行为缺陷和海马神经元损伤
Hina Lateef Nizami,Krishnamoorthy Srinivasan,Shyam Sunder Sharma
Hina Lateef Nizami
Imatinib mesylate, a selective tyrosine kinase inhibitor, exhibited beneficial effects against various neurological diseases besides its anticancer activity. However, its effects on global cerebral ischemia in gerbils remain to be investigated.
Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans [0.03%]
机械压迫可诱导小鼠和人类的神经元凋亡、减少突触活动并促进胶质细胞神经炎症反应
Maksym Zarodniuk,Anna Wenninger,Julian Najera et al.
Maksym Zarodniuk et al.
This work lays the groundwork for therapies that protect neurons from mechanical injury, with relevance not only to GBM but also other neurological diseases that present with mass effect.
The Visual Analogue Test for Anosognosia for Dysphagia: VATA-Dysphagia [0.03%]
用于失语性吞咽障碍的视觉类比测试：VATA-Dysphagia
Cristina Reverberi,Nicoletta Beschin,Martina Barbieri et al.
Cristina Reverberi et al.
Background: Swallowing difficulties (dysphagia) can be associated with a plethora of neurological diseases representing a life-changing condition and, in severe cases, a life-threatening situation....What this paper adds: What is already known on this subject Swallowing difficulties (dysphagia) can be associated with neurological diseases of varying natures and prompt intervention is required to mitigate important complications in everyday life, which can lead to life-threatening
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