Tailoring multidomain intervention programs to reduce cognitive and physical decline in older adults: Examining rural-urban differences in a nationwide cluster-randomized controlled trial [0.03%]
针对农村和城市地区差异制定多领域干预项目以减少老年人的认知和身体功能下降：一项全国范围集群随机对照试验的研究
Min-Yin Ho,Wei-Ju Lee,Ko-Han Yen et al.
Min-Yin Ho et al.
Objectives: To evaluate the impact of rural-urban disparities on the clinical efficacy of a 12-month multidomain intervention for cognitive and physical outcomes in older adults.
Enhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial [0.03%]
通过活动、营养和认知锻炼增强神经认知健康（ENHANCE）：一项随机对照试验
Li-Ning Peng,Pei-Lin Lee,Kun-Hsien Chou et al.
Li-Ning Peng et al.
This randomized controlled trial (ENHANCE) assessed the efficacy of a 12-month group-based multidomain intervention on brain structure and function in community-dwelling older adults, with particular attention to urban-rural disparities.
Randomized Controlled Trial
Journal of cachexia, sarcopenia and muscle. 2025 Jun;16(3):e13830. DOI:10.1002/jcsm.13830 2025
Customizable Rule-Based System for Enhanced Clinical Decision-Making in Dementia Risk Reduction [0.03%]
一种可自定义的基于规则的系统，用于改善痴呆症风险降低的临床决策-making
Laura Pluch,Hannes Hilberger,Markus Bödenler et al.
Laura Pluch et al.
This study presents the development of a customizable rule-based engine, integrated into the LETHE Clinical Trial Management System (CTMS), designed to enhance clinical decision-making in a multidomain intervention for dementia risk reduction.
The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailty in Malaysia: The AGELESS Trial [0.03%]
马来西亚认知脆弱性社区老年人多领域干预的成本效益分析：AGELESS试验报告物理、认知、血管、饮食和心理社会成果的影响
Pavapriya Ponvel,Suzana Shahar,Devinder Kaur Ajit Singh et al.
Pavapriya Ponvel et al.
Participants were randomly assigned to a 24-month multidomain intervention (physical activity, cognitive training, nutritional and psychological counselling, cardiovascular care) or control group (educational module).
Randomized Controlled Trial
Alzheimer's research & therapy. 2025 May 13;17(1):101. DOI:10.1186/s13195-025-01722-w 2025
Multidomain intervention for delaying aging in community-dwelling older adults (MIDA): study design and protocol [0.03%]
针对社区老年人延缓衰老的多领域干预研究——MIDA研究方案
Siyang Lin,Fang Wang,Min Huang et al.
Siyang Lin et al.
The multidomain intervention has the potential to be applied in the field of aging because it concentrates on the functional ability of older adults....There is currently no literature reporting on a multidomain intervention involving cognition, exercise and nutrition for delaying aging....The multidomain intervention comprises cognitive training, exercise training, and nutritional guidance, delivered through both group sessions and individual family interventions....Conclusions: This study will explore the effects of the multidomain intervention on delaying aging in community-dwelling older adults....We aim to introduce a new approach to delaying aging and offer a practical multidomain intervention strategy for healthcare institutions.
Randomized Controlled Trial
Annals of medicine. 2025 Dec;57(1):2496409. DOI:10.1080/07853890.2025.2496409 2025
Multi-domain intervention program on cognitive function in community-dwelling older adults: Pilot study [0.03%]
社区老年人认知功能综合干预方案的试点研究
Rosalinda Sánchez-Arenas,Israel Grijalva,Leticia Manuel-Apolinar et al.
Rosalinda Sánchez-Arenas et al.
Objective: To compare the effectiveness of a multidomain intervention and a sports program (control) on objective cognitive function (OCF), subjective memory function (SMC), frontal assessment battery, cognitive reserve, depression, anxiety, and stress in older adults through a non-randomized
Recruitment and retention in a multidomain intervention for post-TIA and minor stroke: turning challenges into lessons [0.03%]
针对TIA和轻微卒中的多领域干预中人员的招募与保留：化挑战为经验
Micaela Gonçalves,Ana Rute Costa,Maria João Lima et al.
Micaela Gonçalves et al.
Feasibility of a Multidomain Intervention for Safe Mobility in People with Parkinson's Disease and Recurrent Falls [0.03%]
帕金森病和反复跌倒的人安全多领域干预措施的可行性研究
Natalie E Allen,Lina Goh,Colleen G Canning et al.
Natalie E Allen et al.
A tailored, multidomain intervention has the potential to be more effective in improving mobility safety and preventing falls than exercise alone.
Impact of frailty status on the effect of a multidomain lifestyle intervention on cognition [0.03%]
脆弱状态对多领域生活方式干预的认知效果的影响
Johanna Pöyhönen,Jenni Lehtisalo,Hanna-Maria Roitto et al.
Johanna Pöyhönen et al.
They were randomised to receive a multidomain intervention (diet, exercise, cognitive training and vascular risk monitoring) or regular health advice for two years. The outcome was a change in cognition (neuropsychological test battery composite score)....Conclusions: A multidomain intervention is likely to be beneficial to cognition regardless of frailty status. Prefrail participants seemed particularly responsive to preventive intervention.
Randomized Controlled Trial
Age and ageing. 2025 Feb 2;54(2):afaf041. DOI:10.1093/ageing/afaf041 2025
Effect of an unsupervised multidomain intervention integrating education, exercises, psychological techniques and machine learning feedback, on injury risk reduction in athletics (track and field): protocol of a randomised controlled trial (I-ReductAI) [0.03%]
结合教育、运动、心理技术和机器学习反馈的无监督多领域干预措施对田径（赛跑和跳跃）中降低受伤风险的影响：随机对照试验(I-ReductAI)的方案
Spyridon Iatropoulos,Pierre-Eddy Dandrieux,David Blanco et al.
Spyridon Iatropoulos et al.
The primary aim is to assess the impact of a multidomain intervention that integrates education, exercise, psychological techniques and machine learning feedback on the duration athletes remain free from injury complaints leading to participation restriction (ICPR) during a 20-week summer competitive
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