MRS Imaging as Complement to MRI in the Post-treatment Follow-up of Glial Brain Tumors [0.03%]
胶质脑瘤治疗后的随访中MRS与MRI的联合应用
Pablo Moreno-Acosta,Gina Malaver,Cesar Rodriguez et al.
Pablo Moreno-Acosta et al.
Background/aim: Central nervous system tumors have a very low incidence worldwide. However, they represent a significant cause of mortality and morbidity. Magnetic resonance imaging (MRI), magnetic resonance spectroscopy ...
The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study [0.03%]
在精神分裂症早期病程中皮质突触末端密度标志物SV2A与谷氨酸的关系：一项多模式PET和MRS成像研究
Ellis Chika Onwordi,Thomas Whitehurst,Ekaterina Shatalina et al.
Ellis Chika Onwordi et al.
Loss of glutamatergic terminals is hypothesised to contribute to excitation-inhibition imbalance in schizophrenia, supported by evidence that the normal positive association between glutamate concentrations and synaptic terminal density is ...
Dual-Tuned Coaxial-Transmission-Line RF Coils for Hyperpolarized 13C and Deuterium 2H Metabolic MRS Imaging at Ultrahigh Fields [0.03%]
超极化13C和双氢2H代谢MRS成像的超高场双调谐同轴传输线RF线圈
Komlan Payne,Yunkun Zhao,Aditya Ashok Bhosale et al.
Komlan Payne et al.
Objective: Information on the metabolism of tissues in healthy and diseased states plays a significant role in the detection and understanding of tumors, neurodegenerative diseases, diabetes, and other metabolic disorders...
Dual-tuned Coaxial-transmission-line RF coils for Hyperpolarized 13C and Deuterium 2H Metabolic MRS Imaging at Ultrahigh Fields [0.03%]
一种用于超高场代谢MRS成像的双调谐同轴传输线射频线圈，适用于超极化13C和氘(2H)
Komlan Payne,Yunkun Zhao,Aditya Ashok Bhosale et al.
Komlan Payne et al.
Objective: Information on the metabolism of tissues in healthy and diseased states plays a significant role in the detection and understanding of tumors, neurodegenerative diseases, diabetes, and other metabolic disorders...
Noninvasive assessment of myocardial energy metabolism and dynamics using in vivo deuterium MRS imaging [0.03%]
基于氘标记的体内磁共振心肌能量代谢和动态的无创性评价
Tao Wang,Xiao-Hong Zhu,Huan Li et al.
Tao Wang et al.
Purpose: The assessment of cellular energy metabolism is crucial for understanding myocardial physiopathology. Here, we conducted a pilot study to develop an alternative imaging approach for the assessment of myocardial e...
Clinical utility of brain MRS imaging of patients with adult-onset non-cirrhotic hyperammonemia [0.03%]
磁共振波谱技术(MRS)在成人非肝硬化高血氨症患者中的临床应用价值研究
Andrew B Stergachis,Joel B Krier,Sai K Merugumala et al.
Andrew B Stergachis et al.
Adult-onset non-cirrhotic hyperammonemia (NCH) is a rare, but often fatal condition that can result in both reversible and irreversible neurological defects. Here we present five cases of adult-onset non-cirrhotic hyperammonemia wherein bra...
Quantitative and simultaneous measurement of oxygen consumption rates in rat brain and skeletal muscle using 17 O MRS imaging at 16.4T [0.03%]
应用16.4T 17O MRS成像技术定量及同步测量大鼠脑和骨骼肌耗氧率
Hannes M Wiesner,Dávid Z Balla,Klaus Scheffler et al.
Hannes M Wiesner et al.
Purpose: Oxygen-17 (17 O) MRS imaging, successfully used in the brain, is extended by imaging the oxygen metabolic rate in the resting skeletal muscle and used to determine the total whole-body oxygen metabolic rate in th...
In vivo X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging [0.03%]
用于研究大脑功能和衰老的神经能量生物标志物定量评估的体内X核磁共振成像方法
Xiao-Hong Zhu,Wei Chen
Xiao-Hong Zhu
Brain relies on glucose and oxygen metabolisms to generate biochemical energy in the form of adenosine triphosphate (ATP) for supporting electrophysiological activities and neural signaling under resting or working state. Aging is associate...
Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate [0.03%]
通过体内3D磁共振波谱成像探讨了2-羟基谷氨酸突变IDH1抑制剂在胶质瘤患者中的药理动力学
Ovidiu C Andronesi,Isabel C Arrillaga-Romany,K Ina Ly et al.
Ovidiu C Andronesi et al.
Inhibitors of the mutant isocitrate dehydrogenase 1 (IDH1) entered recently in clinical trials for glioma treatment. Mutant IDH1 produces high levels of 2-hydroxyglurate (2HG), thought to initiate oncogenesis through epigenetic modification...
Clinical Trial
Nature communications. 2018 Apr 16;9(1):1474. DOI:10.1038/s41467-018-03905-6 2018
Interleaved 31 P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter-receiver and dynamic B0 shimming [0.03%]
利用单通道发射/接收线圈和动态B0场均匀性校正技术的人类大脑顶叶与枕叶的31P MR波谱成像研究
Byeong-Yeul Lee,Xiao-Hong Zhu,Myung Kyun Woo et al.
Byeong-Yeul Lee et al.
In vivo 31 P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to...
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