Altered Composition of Ceramides and Sphingomyelin Distinctly Modulates the Organizational Landscape and Microdomain Dynamics of Neuronal Plasma Membrane: A Computational Microscopy of Alzheimer's Brain [0.03%]
鞘氨醇脂类组成的变化调节阿尔茨海默病神经元质膜的组织结构和微域动力学：一种计算显微镜方法
Sruthi Peesapati,Sandipan Chakraborty
Sruthi Peesapati
Based on the lipidomics data, we have modeled biologically relevant neuronal model membranes for healthy brain (HB) and diseased condition AD brain (ADB).
Yuto Kado,Kenichi Kawano,Marie Nishikawa et al.
Yuto Kado et al.
We have shown that fibrils formed by Aβ-(1-40) and Aβ-(1-42) on GM1-containing model membranes (M-fibrils) as well as on neuronal cell membranes (C-fibrils) are more toxic compared with fibrils formed in water (W-fibrils), and that Aβ-(1-40) M-fibrils contain both in-register parallel and 2-residue-shifted
Antimicrobial Activity of Nitric Oxide Delivery Nanoparticles for Lipopolysaccharides-Deficient Gram-Negative Bacteria [0.03%]
缺脂多糖革兰氏阴性细菌的纳米颗粒释放抗菌活性氮氧化物研究
Xiangyi Huang,Xiangfeng Lai,Lei Yu et al.
Xiangyi Huang et al.
Advanced microscopic techniques and mechanistic investigations using model membranes mimicking the LPS-deficient A. baumannii membrane and LPS-containing membrane, via neutron reflectometry and small-angle neutron scattering, indicated that the NPs specifically destabilize the LPS-deficient A. baumannii
Coenzyme Q10 Enhances Resilience of Mitochondrial-like Membranes Against Amyloidogenic Peptides [0.03%]
辅酶Q10增强类线粒体膜抵御淀粉样肽的能力
Raina Marie Seychell,Adam El Saghir,Gianluca Farrugia et al.
Raina Marie Seychell et al.
Therefore, we hypothesized that modifying the physicochemical properties of mitochondrial model membranes with a small molecule might act as a countermeasure against the formation of, and damage by, membrane-active amyloid peptides.
Probing bacterial membranes with polarization-resolved second harmonic scattering [0.03%]
利用偏振二次谐波散射探测细菌细胞膜
Eleanor F Page,Marea J Blake,Tessa R Calhoun
Eleanor F Page
PSHS has previously been used with model membranes to extract information about the angular distribution of integrated small molecules. Here we apply pSHS, for the first time, to cells, specifically living Staphylococcus aureus.
Qiwei Yu,Andrej Košmrlj
Qiwei Yu
We use an amplitude expansion to determine the domain size and morphology of patterns that minimize the total free energy, which is validated by numerical simulations and compared against experiments in synthetic model membranes and cell-derived membranes.
Using phase-resolved vibrational sum-frequency imaging to probe the impact of head-group functionality on hierarchical domain structure in lipid membranes [0.03%]
采用相位分辨振动和频成像技术研究头基功能对脂质膜分层结构域结构的影响
Ben John,Sarabjeet Kaur,Martin Wolf et al.
Ben John et al.
In this work, we utilise recently developed phase-resolved azimuthal-scanned sum-frequency generation (SFG) microscopy to investigate structural changes that occur heterogeneously across model membranes as a result of PS-lipid exposure.
Saponins Modulate the Biophysical Properties of Bacterial Model Membranes and Affect Their Interactions with Tobramycin [0.03%]
甘草酸调节细菌模型膜的生物物理性质及其与托布霉素相互作用的影响
Adam Grzywaczyk,Monika Rojewska,Wojciech Smułek et al.
Adam Grzywaczyk et al.
The global challenge of antibiotic resistance necessitates innovative approaches to improving the efficacy of existing therapeutics while mitigating their environmental impact. This study investigates the role of saponins derived from Glycy...
Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid [0.03%]
金黄色葡萄球菌毒素PVL通过与心磷脂和磷脂酸相互作用在酸性条件下破坏模型膜
Seong H Chow,Yusun Jeon,Pankaj Deo et al.
Seong H Chow et al.
Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by Staphylococcus aureus strains that cause severe infections. Bicomponent PVL kills phagocytes depending on cell surface receptors, such as complement 5a receptor 1 (C5aR1)...
Quantitative Analysis of the Influence of Trehalose on Amyloid-β Binding to Membranes by Localized Surface Plasmon Resonance Spectroscopy [0.03%]
利用局域表面等离子共振光谱定量分析海藻糖对淀粉样蛋白-β膜结合的影响
Yue Xu,Danielle M McRae,Zoya Leonenko
Yue Xu
The ability of trehalose to alter the physical properties of model membranes is discussed in relation to its protective role against Aβ during dehydration. © 2025 The Authors.
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