Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer's Disease-like deficits in Tg2576 mice [0.03%]
重复经颅直流电刺激前额叶激活黑质网状部多巴胺能神经元,改善APP/PS1小鼠的认知缺损
Maria Luisa De Paolis,Gilda Loffredo,Paraskevi Krashia et al.
Maria Luisa De Paolis et al.
Moreover, decreased midbrain volume and functional VTA disconnection are identified as predictors of accelerated progression from Mild Cognitive Impairment to AD-dementia in clinical populations.
Midbrain volume in brain herniation: A volumetric analysis in operative traumatic brain injury [0.03%]
脑疝患者丘脑容积的分析研究:一项创伤性脑损伤手术患者的容积分析研究
Jacques Lara-Reyna,Mert Karabacak,Raymond Wedderburn et al.
Jacques Lara-Reyna et al.
Our volumetric analysis revealed that preoperative midbrain volume (5.84 cc vs. 4.37 cc, P = 0.034) was a significant differentiator between GCS 15 and non-GCS 15 groups....Preoperative midbrain volume remained significant in univariate (odds ratio [OR] = 2.280, 95% confidence interval (CI) = 1.126-5.929, P = 0.04) and multivariate logistic regression analysis (adjusted OR = 3.204, 95% CI = 1.228-12.438, P = 0.038) even after adjusting for age, sex, and admission GCS score...Thus, we propose that this preoperative midbrain volume cut-off point holds predictive value for clinical outcomes within our cohort.
Macro- and Micro-Structural Alterations in the Midbrain in Early Psychosis [0.03%]
早发性精神病患者中脑的宏观和微观结构改变
Zicong Zhou,Kylie Jones,Elena I Ivleva et al.
Zicong Zhou et al.
It was found that midbrain volume noticeably correlates with the Cognitive score of PA and all DTI metrics. FA correlates with the several dimensions of the PANSS, while AD and MD do not show many associations with PANSS or CAINS.
Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients [0.03%]
肌痛性脑脊髓炎/慢性疲劳综合征和长新冠患者的脑干体积变化
Kiran Thapaliya,Sonya Marshall-Gradisnik,Markus Barth et al.
Kiran Thapaliya et al.
In long COVID patients a strong negative relationship was detected between midbrain volume and "breathing difficulty."
Differentiating Progressive Supranuclear Palsy and Parkinson's Disease With Head-Mounted Displays [0.03%]
头戴式显示设备在进行进行性核上性麻痹和帕金森病鉴别中的应用
Arvid Herwig,Almedin Agic,Hans-Jürgen Huppertz et al.
Arvid Herwig et al.
In addition, we found for the first time that oculomotor measures (vertical gain, velocity, and the diagnostic index) were correlated significantly to midbrain volume in the PSP group.
Clinical Correlation Between Vertical Gaze Palsy and Midbrain Volume in Progressive Supranuclear Palsy [0.03%]
进行性核上性麻痹中垂直凝视麻痹与中脑体积的临床相关性研究
Karen A Buch,Marc A Bouffard,Randy H Kardon et al.
Karen A Buch et al.
Background: Supranuclear vertical gaze palsies and slowed vertical saccades are characteristic clinic features of progressive supranuclear palsy (PSP). The "hummingbird sign," reflective of midbrain atrophy, is a classic ...
Open-Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy [0.03%]
开标一期功效试验:水杨酸盐和年轻血浆治疗进行性核上性麻痹的功效研究
Lawren VandeVrede,Marian L Dale,Scott Fields et al.
Lawren VandeVrede et al.
PSPRS change from baseline (mean ± standard deviation [SD]) was similar in salsalate (+5.6 ± 9.6), young plasma (+5.0 ± 7.1), and historical controls (+5.6 ± 7.1), and change in midbrain volume (cm3 ± SD) did not differ between salsalate (-0.07 ± 0.03), young plasma (-0.06 ± 0.03), and historical controls
Brainstem volume mediates seasonal variation in depressive symptoms: A cross sectional study in the UK Biobank cohort [0.03%]
脑干体积介导了抑郁症状的季节性变化:英国生物银行队列中的一项横断面研究
Naif A Majrashi,Trevor S Ahearn,Gordon D Waiter
Naif A Majrashi
In females, whole brainstem, pons and medulla volumes individually mediated the relationship between photoperiod and both anhedonia and low mood, while midbrain volume mediated the relationship between photoperiod and anhedonia. No mediation effects were seen in males.
Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants [0.03%]
进行性核上性麻痹临床亚型的脑体积及flortaucipir分析
Jennifer L Whitwell,Nirubol Tosakulwong,Hugo Botha et al.
Jennifer L Whitwell et al.
Compared to PSP-RS, PSP-P had larger midbrain volume and greater flortaucipir uptake in putamen.
Jennifer L Whitwell,Chase A Stevens,Joseph R Duffy et al.
Jennifer L Whitwell et al.
Statistical parametric mapping and midbrain volume were assessed according to disease progression.
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