Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area [0.03%]
黑质和伏隔核多巴胺能神经元的多种起源
José L Ferran,Franco Lucero-Arteaga,Abdelmalik Ayad et al.
José L Ferran et al.
The substantia nigra (SN) and ventral tegmental area (VTA) are key midbrain regions involved in reward, motivation, and motor control....Using a comparative analysis of rodent, non-human primate and human specimens, we were able to demonstrate that TH-positive neurons within the SN and VTA exhibit a multi-neuromeric organization, with neuronal populations distributed across the diencephalic prosomeres (dp1-dp3), the midbrain prosomeres
The mouse posterior insular cortex encodes expressive and receptive aspects of courtship vocalizations [0.03%]
小鼠后绝缘皮层编码求偶声音的表达和感受方面
Thomas Pomberger,Katherine S Kaplan,Rene Carter et al.
Thomas Pomberger et al.
Lastly, tracing experiments reveal that deep-layer neurons in the pIns directly bridge the auditory thalamus to a midbrain vocal gating region.
Resting-state functional connectivity within the reward system mediates subcortical integration during erotic stimulus processing [0.03%]
奖赏系统静息态功能连接在性刺激加工过程中介导皮下整合作用机制研究
Carolina Fiederer,Tara Chand,Louise Martens et al.
Carolina Fiederer et al.
Increased rs-FC between midbrain and NAcc was associated with higher differential neuronal responsiveness in subcortical regions, particularly in the hypothalamus, thalamus and periaqueductal grey....In particular they show that a higher rs-FC between midbrain and NAcc facilitates the simultaneous activation of subcortical brain regions that are relevant for the integration of processes in sexual behaviour.
Isolated congenital third nerve ophthalmoplegia due to potential neurovascular conflict of the posterior cerebral artery [0.03%]
后交通动脉瘤引起的孤立性先天性动眼神经麻痹病例报告
Vinita Gupta,Vishal Thakkar,Udit Chauhan
Vinita Gupta
Oculomotor nerve palsy in children is rare and results from dysfunction along the course of the nerve, extending from the midbrain to its innervation of the extraocular muscles.
Case Reports
BMJ case reports. 2025 Jun 12;18(6):e262438. DOI:10.1136/bcr-2024-262438 2025
Neurotoxicity of chronic nano-neodymium oxide exposure in zebrafish: Behavioral and molecular insights [0.03%]
慢性纳米钕氧化物暴露对斑马鱼神经毒性的影响：行为和分子机制的见解
Bao-Fu Zhang,Xing-Zhe Wu,Jin-Xia Wang et al.
Bao-Fu Zhang et al.
Histopathological analysis revealed developmental delays in brain formation, significant tectal ventricle (TeV) and midbrain ventricle atrophy, deterioration of the periventricular gray zone (PGZ), and decreased Nissl body density in exposed larvae.
Evaluation of disproportionately enlarged subarachnoid-space hydrocephalus in progressive supranuclear palsy [0.03%]
进行性核上性麻痹患者脑积水的评估研究
Mu-Hui Fu,Jeffrey L Gunter,Ryota Satoh et al.
Mu-Hui Fu et al.
The D+E+ participants were older, had more disorientation, more downgaze palsy, greater midbrain and cortical atrophy, lower striatal metabolism, greater degeneration of long-range white matter tracts, larger cistern areas and more periventricular and deep white matter hyperintensities compared to the...The D-E+ participants showed worse disease severity and greater midbrain and cortical atrophy compared to the D-E- participants.
A novel self-organizing embryonic stem cell system reveals the role of WNT signaling parameters in anterior-posterior patterning of the nervous system [0.03%]
一种新型的自我组织的胚胎干细胞系统揭示了WNT信号参数在神经系统前后轴模式建立中的作用
Siqi Du,Aryeh Warmflash
Siqi Du
We found that rather than a smoothly varying gradient along the axis, signaling is elevated in midbrain compared to either surrounding region. The timing, rather than the amplitude or duration, of the Wnt response played the most important role in setting axial coordinates.
Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity [0.03%]
单细胞转录组揭示益生菌可逆转新生鼠阿片类诱导的青少年痛觉过敏相关基因异常
Junyi Tao,Danielle Antoine,Richa Jalodia et al.
Junyi Tao et al.
The midbrain is a core region that plays a central role in pain processing and opioid-mediated analgesia....Here, we performed single-cell RNA sequencing to study gene expression in 107,427 midbrain single cells from adolescent mice neonatally exposed to either saline, morphine, or morphine with the probiotic Bifidobacterium infantis ( B. infantis )....This study presents the first single-cell RNA sequencing dataset of the adolescent midbrain following neonatal morphine exposure and probiotic intervention.
Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids [0.03%]
人脑类器官中的小胶质细胞具有区域特异性多样性，并对携带SCN2A突变的高兴奋性神经元产生反应：类器官中微胶质细胞的多样性和反应性
Jiaxiang Wu,Xiaoling Chen,Jingliang Zhang et al.
Jiaxiang Wu et al.
Highlights: Single-cell RNA sequencing analyses reveal six distinct microglial subtypes that spontaneously attain unique specialization in human cortical, striatal, and midbrain organoids.Microglia facilitate axonal projections across regional organoids, promoting assembloid formation.Microglia
Long-lasting Avoidance Induced by Repeated Stimulation of the Rostromedial Tegmental Nucleus [0.03%]
反复刺激腹中脑核诱导的持久逃避行为
J R Watson,M D De Leon Lopez,E L Carlson et al.
J R Watson et al.
While midbrain dopamine (DA) has been a major focus of study for its role in associative learning, motivation, and reward seeking, far less is known regarding the contribution of inhibitory dopamine inputs in promoting behavioral inhibition and avoidance learning.
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