Alice Morgunova,Nicholas O&#x;Toole,Fatme Abboud et al.
Alice Morgunova et al.
Background: Adolescent depression is linked to enduring maladaptive outcomes, chronic severity of symptoms, and poor treatment response. Identifying epigenetic signatures of adolescent depression is urgently needed to imp...
MicroRNA-7 as a Multifaceted Regulator of Tumor Glycolytic Metabolism: Mechanistic Insights and Therapeutic Perspectives [0.03%]
microRNA-7作为调控肿瘤糖酵解代谢多功能调节因子的作用机制及治疗新视角
Yiling Zhu,Jiayi Zhang,Xu Zhao et al.
Yiling Zhu et al.
Aberrant glycolysis is a hallmark of tumor and a key oncogenic driver. However, the complex regulatory networks and dynamic signaling interactions governing glycolysis within the tumor microenvironment (TME) remain incompletely understood, ...
DNA triangular prism nanostructure and CRISPR/Cas12a empowered electrochemical biosensor for dual detection of alpha-fetoprotein and microRNA 122 [0.03%]
用于同时检测甲胎蛋白和微小核糖核酸122的基于DNA三角棱柱纳米结构及CRISPR/Cas12a的电化学生物传感器
Xuemei Zhang,Li Zhu,Li Yang et al.
Xuemei Zhang et al.
Developing sensitive multi-target-combined detection method is of great significance for the early and accurate diagnosis and prognosis of hepatocellular carcinoma (HCC). Herein, an electrochemical biosensor was proposed for detecting HCC b...
Mutually Activated Dual-Exponential Amplification DNA Machine Enhances Robust CRISPR/Cas12a Feedback Propagation for Ultrasensitive miRNA Detection [0.03%]
互激活的双指数放大DNA机器增强CRISPR / Cas12a反馈传播以实现超灵敏miRNA检测
Qi Wang,Shuo Yang,Xiumei Chen et al.
Qi Wang et al.
Breast cancer (BC) remains a critical global health challenge, necessitating ultrasensitive methods for detecting biomarkers such as miR-155, a key regulator in BC progression. Here, we present a mutually activated dual-exponential amplific...
Retraction Note: Overexpression of LncRNA PIK3CD-AS1 promotes expression of LATS1 by competitive binding with microRNA-566 to inhibit the growth, invasion and metastasis of hepatocellular carcinoma cells [0.03%]
撤回 notice: lncrna piik3cd-as1通过竞争性结合micro RNA-566促进lats1表达以抑制肝癌细胞的生长、侵袭和转移的过表达
Wei Song,Jingjing Zhang,Jianbo Zhang et al.
Wei Song et al.
Evaluation of Organoid-Derived Exosomal microRNA as Liquid Biopsy for Colorectal Cancer: A Multicenter Cross-Sectional Study [0.03%]
基于类器官外泌体的循环microRNA作为结直肠癌液体活检标志物的诊断效能研究：一项多中心横断面研究
Atsuhiro Sasaki,Masatake Kuroha,Masaki Tosa et al.
Atsuhiro Sasaki et al.
Exosomal microRNAs (miRNAs) are candidates for liquid biopsies. Organoid culture systems enable long-term expansion of the colon epithelium. This study evaluated exosomal miRNAs from colorectal cancer organoids for liquid biopsy. Organoids ...
Multicenter Study
Clinical and translational science. 2025 Jun;18(6):e70270. DOI:10.1111/cts.70270 2025
Activity-Based Protein Profiling to Study Virus-Host and Viral-Induced MicroRNA-Host Interactions [0.03%]
基于活性的蛋白质组学研究病毒宿主及病毒诱导的microRNA-宿主互作关系
Parrish Evers,John Paul Pezacki
Parrish Evers
Activity-based protein profiling (ABPP) is a robust technique enabling the user to explore the functional implications of disease and pathology on key protein effectors. As such, a variety of activity-based probes have been developed and ap...
MiR-106b-5p improving the progression of chronic kidney disease by inhibiting the TGF-β/Smad pathway [0.03%]
MicroRNA-106b-5p通过抑制TGF-β/Smads信号通路促进慢性肾脏病进展
Qihao Ma,Li Xu,Peng Zhou et al.
Qihao Ma et al.
Background: Chronic Kidney Disease (CKD) is a progressive disorder marked by renal impairment and declining kidney function. Aims: To i...
MEMO: A micro memo sensor detecting microRNA-RISC using an accurate cell-free expression platform [0.03%]
基于精准无细胞表达平台的微米级microRNA-RISC检测传感器memo研究报告
Caroline E Copeland,Chloe J Heitmeier,Jeehye Kim et al.
Caroline E Copeland et al.
Circulating microRNAs have emerged as potential prognostic biomarkers of various diseases. They serve as micro memos sent out by cells, which scientists can intercept to gain real-time insights into cellular and disease status. However, est...
miR-24-2 targets Akt and inhibits cell survival, EMT, and tumour growth in triple-negative breast cancer [0.03%]
microRNA-24-2靶向Akt并抑制三阴性乳腺癌细胞的存活、上皮间质转化和肿瘤生长
Mansoor Ali,Navneendra Singh,Monika Yadav et al.
Mansoor Ali et al.
Background: Breast cancer is one of the most common types of cancer in the world, and triple-negative breast cancer (TNBC) is an extremely aggressive subtype. This study aimed to investigate the efficacy and mechanisms of...
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