Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation [0.03%]
新颖的秀丽隐杆线虫路易体疾病模型揭示了病理蛋白相互作用和广泛微小rna失调
Rongzhen Li,Xiaobing Huang,Linjing Shen et al.
Rongzhen Li et al.
Lewy body diseases (LBD) comprise a group of complex neurodegenerative conditions originating from accumulation of misfolded alpha-synuclein (α-syn) in the form of Lewy bodies. LBD pathologies are characterized by α-syn deposition in asso...
MiRNA Dysregulation in Brain Injury: An In Silico Study to Clarify the Role of a MiRNA Set [0.03%]
脑损伤中MiRNA失调的组学和计算研究：通过生物信息学和网络分析确定一组miRNA的作用机制
Francesco Sessa,Cristoforo Pomara,Flavia Schembari et al.
Francesco Sessa et al.
Background: The identification of specific circulating miRNAs has been proposed as a valuable tool for elucidating the pathophysiology of brain damage or injury and predicting patient outcomes. ...
Exploring the Potential Link Between COVID-19, MiRNA Dysregulation, and Oral Cancer Risk in Tobacco Chewers [0.03%]
探究COVID-19、miRNA失调与嚼烟草人群口腔癌风险之间的潜在联系
D Ganapathy,S Sekaran,P Ramasamy
D Ganapathy
Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals [0.03%]
探究microRNA失调与乳腺癌发展之间的复杂关系：环境化学物质影响的启示
Narges Abolhasanzadeh,Sajed Sarabandi,Bahar Dehghan et al.
Narges Abolhasanzadeh et al.
Breast cancer stands as the most prevalent form of cancer among women globally, influenced by a combination of genetic and environmental factors. Recent studies have investigated changes in microRNAs (miRNAs) during breast cancer progressio...
Exploring the Impact of TLR-2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration [0.03%]
TLR-2信号对椎间盘退行过程中miRNA表达失调的影响探析
Petra Cazzanelli,Mikkael Lamoca,Oliver Nic Hausmann et al.
Petra Cazzanelli et al.
Toll-like receptors (TLRs) are key mediators of inflammation in intervertebral disc (IVD) degeneration. TLR-2 activation contributes to the degenerative process by increasing the expression of extracellular matrix-degrading enzymes, pro-inf...
Implications of SNP-triggered miRNA dysregulation in Schizophrenia development [0.03%]
SNP引发的miRNA失调对精神分裂症发展的影响
Fadumo Abdullahi Mohamed,Kristine Freude
Fadumo Abdullahi Mohamed
This review examines the substantial involvement of Single Nucleotide Polymorphisms (SNPs) and microRNAs (miRNAs) in the etiology and susceptibility to Schizophrenia, with particular emphasis on the dopaminergic, glutamatergic, and GABAergi...
Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulation [0.03%]
急性辐射暴露通过miRNA失调表现出时间和性别依赖的延迟效应
Gregory P Holmes-Hampton,Dharmendra Kumar Soni,Vidya P Kumar et al.
Gregory P Holmes-Hampton et al.
The detrimental effects of high-dose ionizing radiation on human health are well-known, but the influence of sex differences on the delayed effects of acute radiation exposure (DEARE) remains unclear. Here, we conducted six-month animal exp...
Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating miRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β [0.03%]
吡格列酮通过减轻TGF-β诱导的miRNA失调和自噬功能障碍来保护肾纤维化过程中的肾小管上皮细胞
Anna Manzéger,Gantsetseg Garmaa,Miklós M Mózes et al.
Anna Manzéger et al.
Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknow...
Exosomal microRNA/miRNA Dysregulation in Respiratory Diseases: From Mycoplasma-Induced Respiratory Disease to COVID-19 and Beyond [0.03%]
呼吸道疾病中的外泌体微小核糖核酸失调：从支原体引起的呼吸系统疾病到COVID-19及其以后
Yingjie Wang,Mengyun Zou,Yabo Zhao et al.
Yingjie Wang et al.
Respiratory diseases represent a significant economic and health burden worldwide, affecting millions of individuals each year in both human and animal populations. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are...
MiRNA dysregulation underlying common pathways in type 2 diabetes and cancer development: an Italian Association of Medical Oncology (AIOM)/Italian Association of Medical Diabetologists (AMD)/Italian Society of Diabetology (SID)/Italian Society of Endocrinology (SIE)/Italian Society of Pharmacology ( [0.03%]
二型糖尿病与癌症发病过程中的共同途径：微小核糖核酸失调：意大利肿瘤学协会/意大利医学糖尿病学会/意大利糖尿病学会/意大利内分泌学会/意大利药理学会多学科观点
A Natalicchio,M Montagnani,M Gallo et al.
A Natalicchio et al.
Increasing evidence suggests that patients with diabetes, particularly type 2 diabetes (T2D), are characterized by an increased risk of developing different types of cancer, so cancer could be proposed as a new T2D-related complication. On ...
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