Biomarker analysis and treatment dynamics following preoperative ipilimumab plus nivolumab in locally advanced urothelial cancer from the phase 1B NABUCCO study [0.03%]
NABUCCO研究中局部晚期尿路上皮癌新辅助伊匹木单抗联合纳武利尤单抗的生物标志物分析及治疗动态研究
Chantal F Stockem,Alberto Gil-Jimenez,Hamza Ali et al.
Chantal F Stockem et al.
ScRNAseq in two responders suggested that TCF7+CD8+ T-cells express genes associated with immunological memory formation and T-cell homing.
What's in your plate?AMPA receptors modulation at the crossroads of homeostatic and hedonic eating [0.03%]
你的碟子里有什么？ AMPA受体的调节在稳态和享乐饮食的交汇处
Maria Italia,Diego Scheggia,Monica DiLuca et al.
Maria Italia et al.
Interestingly, peripheral metabolic signals and dietary states can modulate hippocampal synaptic plasticity through AMPAR-dependent mechanisms, thereby affecting meal-related memory formation and retrieval.
Combinative protein expression of immediate early genes c-Fos, Arc, and Npas4 along aversive- and reward-related neural networks [0.03%]
沿逆境和奖赏相关神经网络即早基因c-Fos、Arc和Npas4的组合表达蛋白模式
Mary Arai,Hisayuki Osanai,Chris C Snell et al.
Mary Arai et al.
Expression of immediate early genes (IEGs) is critical for memory formation and has been widely used to identify the neural substrate of memory traces, termed memory engram cells. Functions of IEGs have been known to be different depending on their types.
Unexpected Feedback Enhances Episodic Memory: Exploring Signed and Unsigned Reward Prediction Errors with EEG [0.03%]
意外反馈增强情景记忆：使用EEG探索正负奖励预测误差
Yun Chen,Chunyu Zhao,Rong Liu et al.
Yun Chen et al.
Our results highlight the critical role of unexpected feedback in memory formation and provide novel insights into the mechanisms underlying RPE in episodic memory.
Sachin P Vaidya,Guanchun Li,Raymond A Chitwood et al.
Sachin P Vaidya et al.
We found evidence of memory formation as both the number of PCs maintaining a stable place field and the stability of individual PCs progressively increased across the week until most of the representation was composed of long-term stable PCs.
Synaptic potentiation of engram cells is necessary and sufficient for context fear memory [0.03%]
突触前印迹细胞的活化是情境恐惧记忆产生的充要条件
Leonardo M Cardozo,André F de Sousa,Blythe C Dillingham et al.
Leonardo M Cardozo et al.
These results suggest that plasticity of CS inputs onto US-responsive amygdala neurons underlies memory formation and is necessary and sufficient to establish context fear associations. © 2025. The Author(s).
The amnesic effects of propofol on functional connectivity in the hippocampus determined by functional magnetic resonance imaging in volunteers [0.03%]
异丙酚对健康志愿者海马功能连接影响的磁共振研究
David Lindsay,Ram M Adapa,David K Menon et al.
David Lindsay et al.
Background: One of the primary actions of general anaesthetic agents, apart from inducing a state of unconsciousness, is reversible impairment of memory formation during the period of administration.
Sofia Uribe,Holly J Bowen,Alicia E Meuret
Sofia Uribe
Downstream effects are also hypothesized for episodic memory with impairments particularly for positive information due to dopamine dysregulation from anhedonia affecting memory formation processes.
Diversity of clustered protocadherin-α genes in neuronal identity and its role in short-term specific associative memory formation [0.03%]
簇集原钙黏着蛋白-α基因的多样性在神经元身份和短期特异性联想记忆形成中的作用
Tomoki Osuka,Hiroki Yamamoto,Takeshi Yagi
Tomoki Osuka
Clustered protocadherins (cPcdh) are cell adhesion molecules with 58 isoforms, essential for neural circuit formation and higher cognitive functions. This study investigated the impact of reduced cPcdh-α diversity on cognitive function usi...
Impact of positive feelings and negative feelings on brain cell regeneration and degeneration [0.03%]
积极情绪和消极情绪对脑细胞再生与退变的影响
Al-Hassan Soliman Wadan,Mohamed Abdelsattar Ahmed,Dana Saeed Abd Elmonem El Gemaie et al.
Al-Hassan Soliman Wadan et al.
Brain cells intentionally break their DNA as a crucial step in memory formation and learning. This process allows for the expression of specific genes that are essential for these cognitive functions.
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