Anna I Malykhina,Svetlana S Efimova,Olga S Ostroumova
Anna I Malykhina
Background/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation. They have been tested for a broad varie...
Molecular and Signaling Mechanisms for Docosahexaenoic Acid-Derived Neurodevelopment and Neuroprotection [0.03%]
由二十碳六烯酸衍生的神经发育和神经营养的分子及信号机制
Hee-Yong Kim,Bill X Huang,Arthur A Spector
Hee-Yong Kim
A key characteristic in the membrane-mediated action of DHA results from the stimulated synthesis of neuronal phosphatidylserine (PS). The resulting DHA-PS-rich membrane domains facilitate the translocation and activation of kinases such as Raf-1, protein kinase C (PKC), and Akt.
Refining Protein Penetration into the Lipid Bilayer Using Fluorescence Quenching and Molecular Dynamics Simulations: The Case of Diphtheria Toxin Translocation Domain [0.03%]
应用荧光淬灭和分子动力学模拟改进白喉毒素跨膜结构域向脂质双层的穿透实验：以白喉毒素为例
Alexander Kyrychenko,Nathan M Lim,Victor Vasquez-Montes et al.
Alexander Kyrychenko et al.
We apply this approach to characterize membrane-mediated action of the diphtheria toxin translocation domain.
Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism [0.03%]
内源大麻素花生四烯乙醇胺通过膜介导的对膜蛋白的作用：理解受体非依赖机制的意义
Djalma Medeiros,Laíz da Costa Silva-Gonçalves,Annielle Mendes Brito da Silva et al.
Djalma Medeiros et al.
Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoi...
Progestins can have a membrane-mediated action in rat midbrain for facilitation of sexual receptivity [0.03%]
孕激素可以通过大鼠中脑的膜介导作用促进性接受行为
C A Frye,S G Gardiner
C A Frye
In rats, progesterone (P) facilitates sexual receptivity by interacting with intracellular progestin receptors in the ventromedial hypothalamus (VMH). This experiment concerns whether P can also facilitate receptivity in rats by acting extr...
Adrenergic inhibition of the stimulatory effect of 3,5,3'-triiodothyronine on calcium accumulation and cytoplasmic free calcium concentration in rat thymocytes. Further evidence in support of the concept that calcium serves as the first messenger for the prompt action of thyroid hormone [0.03%]
肾上腺素阻抑三碘甲腺原氨酸对大鼠胸腺细胞钙积聚及胞浆游离钙浓度的刺激作用-进一步支持钙为甲状腺素速效作用第一信使的观点
J Segal
J Segal
Hence, the present study provides further support for the concept that calcium serves as the first messenger in the rapid, plasma membrane-mediated action of thyroid hormone in the rat thymocyte.
J Segal
J Segal
A model for the mechanism of action of thyroid hormone at the plasma membrane level to increase sugar uptake by rat thymocytes is delineated, and the physiological role of the plasma membrane-mediated action of thyroid hormone is discussed.
Calcium is the first messenger for the action of thyroid hormone at the level of the plasma membrane: first evidence for an acute effect of thyroid hormone on calcium uptake in the heart [0.03%]
甲状腺激素在细胞水平上作用的首个信号是钙离子：首次获得关于甲状腺激素对心脏钙吸收急性效应的证据
J Segal
J Segal
The present study provides conclusive evidence for two central issues: that calcium is the first messenger for the prompt, plasma membrane-mediated action of thyroid hormone to increase cellular sugar uptake, and that thyroid hormone produces an acute increase in calcium uptake by the heart, an effect
Comparative Study
Endocrinology. 1990 May;126(5):2693-702. DOI:10.1210/endo-126-5-2693 1990