S-acyl transferase ZDHHC13 modulates tumor microenvironment interactions to suppress metastasis in melanoma models [0.03%]
锌指蛋白泛疏基化酶ZDHHC13通过调节肿瘤微环境抑制黑色素瘤转移的功能与机制研究
Hongjin Li,Jianke Lyu,Yu Sun et al.
Hongjin Li et al.
Our study highlights the therapeutic potential of targeting the ZDHHC13-E-cadherin axis and its downstream metabolic and immune-modulatory mechanisms, offering additional strategies to inhibit melanoma progression and metastasis.
Targeting Neuropilin-1 to Enhance Immunotherapy in Melanoma: Reducing Peripheral Treg-Mediated Immunosuppression and Tumour Progression [0.03%]
靶向神经纤毛蛋白-1可增强黑色素瘤免疫治疗：减少外周Tregs介导的免疫抑制和肿瘤进展
Somlata Khamaru,Kshyama Subhadarsini Tung,Subhasis Chattopadhyay
Somlata Khamaru
These findings suggest that targeting NRP1 could slow melanoma progression and reduce peripheral Treg-mediated immunosuppression, making it a promising approach for future cancer immunotherapies, especially in combination with other treatments.
WTAP Suppresses Cutaneous Melanoma Progression by Upregulation of KLF9: Insights into m6A-Mediated Epitranscriptomic Regulation [0.03%]
WTAP通过上调KLF9抑制皮肤黑色素瘤的进展：mRNA甲基化介导的表遗传调控研究新 insight
Huayu Huang,Dong Li,Yichuan Li et al.
Huayu Huang et al.
Background: N6-methyladenosine (m6A) modification plays a crucial role in tumor biology; however, the function of the methyltransferase adaptor WTAP in melanoma remains poorly understood. Methods: We analyzed WTAP expression and its clinica...
The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1 [0.03%]
细胞周期调节因子PLK1通过调控转录因子BACH1促进小鼠黑色素瘤的进程
Fengyi Mao,Sai Wu,Derek B Allison et al.
Fengyi Mao et al.
Polo-like kinase 1 (PLK1), a critical cell cycle regulator, is associated with cancer progression and negatively correlates with patient survival in cutaneous melanoma based on clinical database analysis. In a melanoma mouse model induced b...
COMMD4 Drives Skin Cutaneous Melanoma Progression by Targeting PI3K-p85 to Activate PI3K-AKT [0.03%]
COMMD4通过靶向PI3K-p85激活PI3K-AKT驱动皮肤黑色素瘤进展
Xiaoqiang Liu,Luojia Liu,Qiaoling Wang et al.
Xiaoqiang Liu et al.
Skin cutaneous melanoma (SKCM), the most aggressive form of cutaneous malignancy globally, remains poorly understood in terms of its molecular drivers. Although the copper metabolism MURR1 domain (COMMD) protein family has been associated w...
Catestatin suppresses melanoma progression and drug resistance through multitargeted modulation of signaling pathways [0.03%]
猫统计蛋白通过多靶标调节信号通路抑制黑色素瘤进展和药物耐药性
Satadeepa Kal,Suborno Jati,Kechun Tang et al.
Satadeepa Kal et al.
These findings identify CST as a promising therapeutic prototype for mitigating melanoma progression and overcoming resistance to targeted therapy.
Proteomic analysis of small extracellular vesicles from lymphatic affluents in developing premetastatic niche in melanoma [0.03%]
黑色素瘤发展前期转移微环境淋巴引流中外泌体蛋白质组分析
Shankar Suman,Liyi Geng,Wendy K Nevala et al.
Shankar Suman et al.
Hierarchical clustering with postoperative samples demonstrated 9 upregulated and 2 downregulated proteins specific to melanoma sEVs, which are associated with melanoma progression (p < 0.05).
Correction: A20 promotes melanoma progression via the activation of Akt pathway [0.03%]
关于A20通过活化Akt途径促进黑色素瘤发展的更正公告
Jinyuan Ma,Huina Wang,Sen Guo et al.
Jinyuan Ma et al.
Published Erratum
Cell death & disease. 2025 Nov 20;16(1):847. DOI:10.1038/s41419-025-08121-x 2025
Systemic Immune-Inflammation Index as a Predictor of Progression in Melanoma: A Retrospective Cohort Study [0.03%]
系统免疫炎症指数可预测黑色素瘤进展：回顾性队列研究
Ana G Perez-Romero,Martha A Aceves Villalvazo,Arcelia Y Figueroa Martínez et al.
Ana G Perez-Romero et al.
Background: Systemic inflammation plays a pivotal role in melanoma progression through mechanisms of immune suppression, angiogenesis, and metastatic dissemination.
Senescent Fibroblasts Drive Melanoma Progression Through GCP-2 Induced CREB Phosphorylation Enhancing Glycolysis [0.03%]
衰老成纤维细胞通过GCP-2诱导的CREB磷酸化增强糖酵解促进黑色素瘤进展
Abhijit Basu,Vida Farsam,Karmveer Singh et al.
Abhijit Basu et al.
Aging constitutes the largest risk factor for melanoma progression. While a contribution of factors secreted from senescent skin fibroblasts to the progression of melanoma has been proposed, the nature of such factors and subsequent underly...
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