Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration [0.03%]
巨噬细胞摄取坏死椎间盘细胞作为治疗椎间盘退变的新策略
Shijie Chen,Haijun Zhang,Zhaoheng Wang et al.
Shijie Chen et al.
In recent years, a growing number of studies have disclosed the substantial role of macrophages-key immune cells-in the pathological process of intervertebral disc degeneration. Researchers have categorised macrophage phenotypes into M1 and...
Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes [0.03%]
2型糖尿病患者单核细胞和单核细胞衍生巨噬细胞的清除功能受损
Qian-Yun Mao,Hui Ran,Qiu-Yue Hu et al.
Qian-Yun Mao et al.
Multivariate linear regression analysis in diabetes patients demonstrated that the monocyte efferocytosis index was independently associated with the HbA1c level, and that the macrophage efferocytosis index was significantly associated with the percentage of CD14+ macrophages.
CD34+CD45+ cells promote alveolar macrophage efferocytosis to alleviate phosgene-induced acute lung injury in rats [0.03%]
小鼠CD34⁺CD45⁺细胞通过促进肺泡巨噬细胞摄取凋亡细胞缓解磷酰氯致急性肺损伤的作用及机制研究
Xuanrong Bao,Yu Dun,Hanbing Hu et al.
Xuanrong Bao et al.
Moreover, it was observed that CD34+CD45+ cells promoted macrophage efferocytosis ex vivo and in vitro. Exosomes derived from CD34+CD45+ cells were further demonstrated to mediate the enhancement of macrophage efferocytosis.
Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing [0.03%]
远程神经肌肉电刺激通过LRP1上调MDK以增强巨噬细胞的凋亡细胞吞噬作用从而促进伤口愈合
Lijuan Zong,Chong Liu,Li Zhang et al.
Lijuan Zong et al.
MDK significantly enhanced macrophage efferocytosis in a low-density lipoprotein receptor-related protein 1 (LRP1)-dependent manner.
Mechanism of adipose-derived stem cell-derived extracellular vesicles affecting macrophage efferocytosis by mediating ADAM17/MerTK in the apoptosis of tubular epithelial cells after sepsis-associated acute kidney injury [0.03%]
脓毒症相关急性肾损伤后间充质干细胞来源的细胞外囊泡通过介导ADAM17/Mertk影响肾小管上皮细胞凋亡中巨噬细胞胞葬作用的机制研究
Zhixiang Bian,Xiangxiang Wang,Xiaoxuan Su et al.
Zhixiang Bian et al.
ADSC-EVs down-regulated ADAM17 and sMerTK, and increased cell membrane MerTK, macrophage recognition of apoptotic cells and efferocytosis, and M2 polarization in renal tissues of S-AKI mice and LPS-induced mouse renal macrophages, indicating that ADSC-EVs regulated ADAM17/MerTK-mediated macrophage efferocytosis...MerTK silencing partially reversed ADSC-EVs-regulated LPS-induced mouse renal macrophage efferocytosis and M2 polarization....Conclusion: ADSC-EVs down-regulated sMerTK level and up-regulated macrophage membrane MerTK protein level by modulating ADAM17 to promote macrophage efferocytosis and ameliorate post-S-AKI TEC apoptosis and inflammation.
Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix [0.03%]
通过调节αC螺旋构象设计有效的选择性的MerTK抑制剂
Yi-Hui Peng,Mu-Chun Li,Wan-Ching Yen et al.
Yi-Hui Peng et al.
MerTK, a TAM receptor, regulates macrophage efferocytosis and polarization, and its inhibition holds potential for tumor growth suppression and immune modulation.
Dual Exosome Coating for Modulating Endothelial Function and Inflammation [0.03%]
用于调节内皮功能和炎症的双重外体涂层
Yangyang Xiao,Jianan Liu,Fanfan Dai et al.
Yangyang Xiao et al.
In this study, a dual exosome coating was fabricated to promote endothelial function and macrophage efferocytosis via a synergistic effect by endothelial cell-sourced and mesenchymal stem cell-sourced exosomes.
Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis [0.03%]
髓系EGFR缺乏通过巨噬细胞胞葬作用和中性粒细胞凋亡加速AKI恢复
Yu Pan,Shirong Cao,Yinqiu Wang et al.
Yu Pan et al.
Altered expression and activation of Epidermal Growth Factor Receptor (EGFR) is implicated in acute and chronic kidney injury. One of the important cellular sources of EGFR is the myeloid compartment, which plays roles in both acute kidney ...
LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis [0.03%]
长链非编码RNA SCARNA8通过抑制巨噬细胞胞葬作用促进动脉粥样硬化斑块不稳定性
Xiaoliang Yin,Xiaodong Chen,Tao Wang et al.
Xiaoliang Yin et al.
In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of...
USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARγ [0.03%]
USP22通过稳定PPARγ来增强动脉粥样硬化斑块稳定性及巨噬细胞摄取凋亡细胞能力
Senhu Tang,Chuanghong Lu,Zhongyuan Meng et al.
Senhu Tang et al.
In vitro, USP22 silencing enhanced macrophage inflammation and foam cell formation, and macrophage efferocytosis was significantly impaired.
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