Semaphorin3A Rewires CD4+ T-Cell Metabolism via AKT/mTORC1 Inhibition in Health and Rheumatoid Arthritis [0.03%]
Semaphorin3A通过AKT/mTORC1抑制重新布线CD4⁺T细胞代谢：健康与类风湿关节炎中的作用
Raeda Mubariki,Nasren Eiza,Adi D Sabag et al.
Raeda Mubariki et al.
Semaphorin3A (Sema3A) is a regulatory protein found to be expressed on regulatory T and B cells and also secreted into peripheral blood. It has been identified as a potent immune regulator; however, not all its regulatory mechanisms have be...
Preclinical Evaluation of mTORC1 Inhibition via Rapamycin in Machine-Perfused Rodent Livers [0.03%]
雷帕霉素抑制mTORC1的肝机器灌注试验研究
Christopher Taveras,Alissa Cutrone,Emmanuella Ajenu et al.
Christopher Taveras et al.
Normothermic machine perfusion (NMP) enables real-time liver viability assessment and therapeutic intervention during preservation. Rapamycin, an mTORC1 inhibitor known to induce autophagy and promote cellular resilience, represents a promi...
MTDH∆7-mediated mTOR activation drives doxorubicin resistance in triple-negative breast cancer: Relevance of mTORC1 inhibition on chemosensitization [0.03%]
MTDHΔ7介导的mTOR活化驱动三阴性乳腺癌对多柔比星产生抗性：mTORC1抑制在增加化疗敏感性的相关性
Shashikanta Sahoo,Sunita Kumari,Praveen Kumar Neeli et al.
Shashikanta Sahoo et al.
Cancer chemoresistance poses a major hurdle in the management of several cancers, including breast cancer. Herein, we identified MTDH∆7, a splice variant of an oncogene, metadherin (MTDH), promotes doxorubicin (Dox)-induced chemoresistance...
Loss of Kmt2c / d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy [0.03%]
Kmt2c/d缺失促进胃癌的发生发展并导致对mTORC1抑制剂和抗PD-1免疫治疗的敏感性增加
Naitao Wang,Dan Li,Tao Zhang et al.
Naitao Wang et al.
KMT2C and KMT2D ( KMT2C/D ) are frequently mutated in gastric adenocarcinoma, yet their function in cancer initiation remains poorly understood. In this study, based on the observation that loss-of-function mutations of KMT2C and KMT2D are ...
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics [0.03%]
KRASG12C/mTORC1抑制在非小细胞肺癌治疗中的强强联合疗法
Antonios N Gargalionis,Kostas A Papavassiliou,Athanasios G Papavassiliou
Antonios N Gargalionis
In a recent report in Nature Communications, Kitai et al. designed a combinational treatment based on targeting the active-state KRASG12C-mutant variant that characterizes a substantial subset of non-small-cell lung cancer (NSCLC) cases. Th...
Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition [0.03%]
溶酶体TBK1响应氨基酸的可用性来缓解Rab7依赖性的mTORC1抑制作用
Gabriel Talaia,Amanda Bentley-DeSousa,Shawn M Ferguson
Gabriel Talaia
Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosom...
Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines [0.03%]
二甲双胍通过抑制mTORC1诱导ZFP36在宫颈癌系中表达
Karen Griselda De la Cruz-López,Eduardo Alvarado-Ortiz,Heriberto A Valencia-González et al.
Karen Griselda De la Cruz-López et al.
Background: Metformin, a widely prescribed antidiabetic drug, has shown several promising effects for cancer treatment. These effects have been shown to be mediated by dual modulation of the AMPK-mTORC1 axis, where AMPK a...
eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition [0.03%]
eIF4A1增强mTORC1抑制过程中的LARP1介导的翻译抑制作用
Yuichi Shichino,Tomokazu Yamaguchi,Kazuhiro Kashiwagi et al.
Yuichi Shichino et al.
Eukaryotic translation initiation factor (eIF)4A-a DEAD-box RNA-binding protein-plays an essential role in translation initiation. Recent reports have suggested helicase-dependent and helicase-independent functions for eIF4A, but the multif...
Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition [0.03%]
溶酶体TBK1响应氨基酸的可用性来缓解Rab7依赖性的mTORC1抑制作用
Gabriel Talaia,Amanda Bentley-DeSousa,Shawn M Ferguson
Gabriel Talaia
Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosom...
Clearance of β-amyloid mediated by autophagy is enhanced by MTORC1 inhibition but not AMPK activation in APP/PSEN1 astrocytes [0.03%]
APP/PSEN1星形胶质细胞中自噬介导的β-淀粉样蛋白清除通过抑制MTORC1而不是激活AMPK而增强
Marta García-Juan,Lara Ordóñez-Gutiérrez,Francisco Wandosell
Marta García-Juan
Proteostasis mechanisms mediated by macroautophagy/autophagy are altered in neurodegenerative diseases such as Alzheimer disease (AD) and their recovery/enhancement has been proposed as a therapeutic approach. From the two central nodes in ...
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