Statistical analysis of long-term physical stability testing of amorphous solid dispersions [0.03%]
长期物理稳定性的统计分析-有关无定形固体分散体的例子
Jingya Wu,Guy Van den Mooter
Jingya Wu
The current study investigates how various factors affect the long-term physical stability of ASDs, focusing on both procedural and molecular-level influences.
Impact of additives on the long-term physical stability of antidepressant citalopram hydrobromide in personalized drug delivery systems [0.03%]
辅料对个性化给药系统中抗抑郁药物盐酸西塔普雷长期物理稳定性的影响研究
Natalja Genina,Wuzhong He,Dhara Raijada et al.
Natalja Genina et al.
This study aimed to investigate the effect of the manufacturing process, composition, and storage on the long-term physical stability of antidepressant citalopram hydrobromide (CHB) in oral solid foams as personalized drug delivery systems....These findings indicate that CHB-loaded solid foams should be stored in a cold and dry environment, or the formulation without additives should be used to ensure the long-term physical stability of ingredients in the foam.
Long-term versus short-term stress physical stability assessment of pharmaceutical nano- and microsuspensions [0.03%]
长效与短效压力下的药用纳微悬液的物理稳定性评估
Nadina Zulbeari,René Holm
Nadina Zulbeari
Short-term stress studies are often used as predictive studies to evaluate the long-term physical stability of pharmaceutical suspensions.
Rational design of PLA-based ASDs for pharmaceutical 3D printing: Insights from phase diagram modeling [0.03%]
基于相图模型的PLA基ASDs在制药3D打印中的理性设计：来自相图建模的见解
Alma Lucia Villela Zumaya,Anton Iemtsev,Michal Fulem et al.
Alma Lucia Villela Zumaya et al.
The correlation between the predicted phase behavior and long-term physical stability highlights the potential of phase diagram modeling as a tool for the rational design of ASDs in pharmaceutical 3D printing.
Creation of Long-Term Physical Stability of Amorphous Solid Dispersions N-Butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide, Resistant to Recrystallization Caused by Exposure to Moisture [0.03%]
制备无定形固态分散体系N-丁基-N-甲基-1-苯基吡咯并[1,2-a]吡嗪-3-羧酰胺，使其在受潮时仍保持物理稳定性且不发生重结晶现象
Vladimir B Markeev,Evgenia V Blynskaya,Konstantin V Alekseev et al.
Vladimir B Markeev et al.
Amorphous solid dispersion (ASD) technology is often used as a promising strategy to improve the solubility of active pharmaceutical ingredients (APIs). ASDs allow APIs to be dispersed at the molecular level in a polymer carrier, destroying...
Drug-Phospholipid Co-Amorphous Formulations: The Role of Preparation Methods and Phospholipid Selection [0.03%]
药物-磷脂共无定形单元剂型：制备方法和磷脂选择的作用
Keyoomars Khorami,Sam Darestani Farahani,Anette Müllertz et al.
Keyoomars Khorami et al.
The long-term physical stability of the CAPSs was investigated at room temperature under dry conditions (0% RH) and at 75% RH. The dissolution behavior of the CCX CAPS and RIT CAPS was studied.
Microfluidic-Integrated Chip Resonators for Electron Spin Sensing in Submicromolar, Submicroliter Solutions [0.03%]
用于亚微摩尔、亚微升溶液中电子自旋检测的集成毛细管芯片谐振器
Nandita Abhyankar,Megan A Catterton,Gregory A Cooksey et al.
Nandita Abhyankar et al.
Here, we report microfluidic devices that decrease the total required sample volume to the submicroliter scale and also provide long-term physical stability and storability.
Long-Term Physical Stability of Amorphous Solid Dispersions: Comparison of Detection Powers of Common Evaluation Methods for Spray-Dried and Hot-Melt Extruded Formulations [0.03%]
喷雾干燥和熔融挤出无定形固体分散体制备的口服固体制剂的长期物理稳定性比较研究：常用评价方法检测能力的对比分析
Kohsaku Kawakami,Taichi Ishitsuka,Masafumi Fukiage et al.
Kohsaku Kawakami et al.
Although physical stability can be a critical issue during the development of amorphous solid dispersions (ASDs), there are no established protocols to predict/detect their physical stability. In this study, we have prepared fenofibrate ASD...
Polymer-inducing chemical degradation of amorphous solid dispersions driven by drug-polymer interactions for physical stabilization [0.03%]
由药物-聚合物相互作用驱动的物理稳定无定形固态分散体系中聚合物诱导化学降解现象的研究
Taro Kojima,Junpei Takeda,Yang Song et al.
Taro Kojima et al.
Intermolecular interactions between active pharmaceutical ingredients (APIs) and carrier polymers are important for the long-term physical stability of amorphous solid dispersions (ASDs). However, the negative impact of intermolecular interactions on chemical stability has rarely been reported.
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions [0.03%]
自闭症谱系障碍的货架期：2. 预测储存条件下的货架期
Friederike Wolbert,Christian Luebbert,Gabriele Sadowski
Friederike Wolbert
This work presents a method for predicting the long-term physical stability of ASDs (crystallization onset time). The new approach combines the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equation with classical nucleation theory.
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