In vitro and in vivo toxicological evaluation of 6'-Sialyllactose sodium salt produced by a novel method [0.03%]
一种新型方法生产6'-岩藻糖基乳糖钠盐的体内外毒理学评价研究
Rit B Gurung,Laurie C Dolan,Benjamin G Arceneaux et al.
Rit B Gurung et al.
The results of genetic toxicity tests (bacterial reverse mutation assay, an in vitro mammalian chromosome aberration test, and an in vivo micronucleus test in mice), and acute and 26-week repeated dose oral toxicity studies in rats for this novel 6'-SL sodium salt are reported herein.
Safety and Toxicity of Qi-Fu Yin, a Classical Traditional Chinese Medicine Prescription: A Nonclinical Research [0.03%]
益气复福饮经典名方安全性及毒性研究——非临床部分
Kai Chen,Xuemin Yao,Ying Yu et al.
Kai Chen et al.
Additionally, the genotoxicity of QFYEP was assessed using the Ames test, an in vitro chromosome aberration test, and an in vivo micronucleus test.
Takako Iso,Takaaki Umano,Kei-Ichi Sugiyama et al.
Takako Iso et al.
The point of departure (PoD) for aneugenicity was calculated based on a dose-response analysis from in vivo micronucleus tests using the benchmark dose (BMD) approach.
In vitro and in vivo genotoxicity assessments of Ficus erecta Thunb. leaves extract support its functional and pharmaceutical potential [0.03%]
Forsythia suspense 叶片提取物的体内外遗传毒性评估支持其功能和药用潜力
Mee-Young Lee,Yu Jin Kim,Woo-Young Jeon et al.
Mee-Young Lee et al.
The in vivo micronucleus test revealed that EEFE did not influence the frequency of bone marrow micronuclei up to 2000 mg/kg body weight of male ICR mice. Moreover, no changes in mouse body weight or mortality rates were observed.
Protective Effect of Silver Nanoparticles Against Cytosine Arabinoside Genotoxicity: An In Vivo Micronucleus Assay [0.03%]
银纳米粒子对胞苷阿拉伯糖苷遗传毒性的保护作用：一项体内微核试验研究
Idalia Yazmin Castañeda-Yslas,Olivia Torres-Bugarín,María Evarista Arellano-García et al.
Idalia Yazmin Castañeda-Yslas et al.
Cancer treatments have harmful side effects, including genotoxic ones. Our previous research discovered that a specific silver nanoparticle (AgNPs) formulation could reduce the genotoxic effects of an alkylating agent, cyclophosphamide. Thi...
In vivo micronucleus assay on sodium molybdate in rats and its impact on the overall assessment of the genotoxicity of molybdenum substances [0.03%]
钼酸钠对大鼠的体内微核试验及其对评估总体钼化合物遗传毒性的影响
Sue A Hubbard,Kevin Klipsch,Michael S Cockburn et al.
Sue A Hubbard et al.
In this paper we present methodological and experimental details and results from an OECD Test Guideline 474 and GLP-compliant in vivo micronucleus study on sodium molybdate dihydrate in Sprague Dawley rats.
Cellular and Genomic Instability Induced by the Herbicide Glufosinate-Ammonium: An In Vitro and In Vivo Approach [0.03%]
草甘膦铵诱导的细胞和基因组不稳定：体内外方法研究
Alfredo Santovito,Mattia Lambertini,Dáša Schleicherová et al.
Alfredo Santovito et al.
We assessed, by in vitro and in vivo micronucleus assays, the genotoxicity of GLA on cultured human lymphocytes and Lymnaea stagnalis hemocytes at six concentrations: 0.010 (the established acceptable daily intake value), 0.020, 0.050, 0.100, 0.200, and 0.500 µg/mL.
Oral subchronic toxicity study and genetic toxicity evaluation of mitoquinone mesylate [0.03%]
甲磺酸辅酶Q₁₇₁口服亚慢性毒性研究及遗传毒性评价
E Siobhan Mitchell,Shawna Lemke,Brendon Woodhead et al.
E Siobhan Mitchell et al.
Mitoquinone mesylate showed no evidence of genotoxic potential in two in vitro assays, bacterial reverse mutation and human lymphocyte chromosome aberration, nor in the in vivo micronucleus test in rats.
An investigation of the genotoxic potential of a well-characterized yerba mate extract [0.03%]
一种特征明显的马黛茶提取物的致基因毒性潜力的研究
C Doepker,C Rabert,P Heard et al.
C Doepker et al.
However, oral gavage treatment of rats for the in vivo micronucleus and comet assays demonstrated negative findings. The results from this battery of tests, supports that this yerba mate hydroxycinnamic acid extract is not anticipated to pose genotoxicity concerns.
Subjective biosafety assessment of bisdemethoxycurcumin from the rhizomes of Curcuma longa [0.03%]
姜黄根茎中双去甲氧基姜黄素的主观生物安全评价
Muhammed Majeed,Sarang Bani,Anjali Pandey et al.
Muhammed Majeed et al.
The results of genotoxicity as evaluated by in vitro reverse mutation assay, and in vivo micronucleus test in mice indicate that BDMC did not induce any genotoxic effects.Conclusion: Oral administration of BDMC is safe in rodents and non-mutagenic, with no adverse effects under experimental conditions
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