Topological influence of immediate-early genes in brain genetic networks and their link to Alzheimer's disease [0.03%]
脑基因网络中早期立即基因的拓扑学影响及其与阿尔茨海默病的联系
Margarita Zachariou,Eleni M Loizidou,George M Spyrou
Margarita Zachariou
Immediate-early genes (IEGs), a subset of activity-regulated genes (ARGs), are rapidly and transiently activated by neuronal activity independent of protein synthesis. While extensively researched, the role of IEGs within genetic networks a...
Unveiling the impact of simulated microgravity on HSV-1 infection, neuroinflammation, and endogenous retroviral activation in SH-SY5Y cells [0.03%]
模拟微重力对SH-SY5Y细胞中HSV-1感染，神经炎症和内源性逆转录病毒激活的影响分析
Seyedesomaye Jasemi,Elena Rita Simula,Kawaguchi Yasushi et al.
Seyedesomaye Jasemi et al.
In addition, there was a significant correlation between HSV-1 immediate-early genes with HERVs and pro-inflammatory cytokine gene expression, with stronger correlations observed under µg conditions.
Midnolin Correlates With Anti-Tumour Immunity and Promotes Liver Cancer Progression Through β-Catenin [0.03%]
Midnolin与抗肿瘤免疫相关并通过β-catenin促进肝癌进展
Shaobo Huang,Jinling Zhang,Ting He et al.
Shaobo Huang et al.
Previous research has found that those immediate-early genes are involved in tumour progression. However, the role of MIDN is still not clearly identified in human cancers. With the help of the TCGA, GTEx, and HPA databases, we revealed that the expression of MIDN was disordered in cancers.
Prenatal Alcohol Exposure Inhibits Transient Expression of Autophagy and Synaptic Proteins in Developing Brain [0.03%]
产前酒精暴露抑制发育大脑中自噬和突触蛋白的瞬时表达
Monica Hampe,Nune Darbinian,Nana Merabova et al.
Monica Hampe et al.
Several immediate-early genes were upregulated, but SYNPO, which is involved late in synaptic plasticity was downregulated 78%.
Extinction of contextual fear memory is facilitated in TRPM2 knockout mice [0.03%]
TRPM2基因敲除小鼠中上下文恐惧记忆的消退加速
Seung Yeon Ko,Do Gyeong Kim,Huiju Lee et al.
Seung Yeon Ko et al.
The enhanced extinction in Trpm2-/- and FFA-treated mice was associated with down-regulation of immediate-early genes (IEGs) including Npas4, c-Fos, Arc and Egr1 in the hippocampus after extinction training.
Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex [0.03%]
视觉皮层中细胞类型和视觉依赖性转录组程序相互作用的空间分布分析
Fangming Xie,Saumya Jain,Runzhe Xu et al.
Fangming Xie et al.
The first, induced specifically in the visual cortex, includes immediate-early genes and genes associated with metabolic processes. It manifests as a change in cell state that is orthogonal to cell-type-specific gene expression programs.
Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in Huntington disease [0.03%]
雌激素受体相关受体gamma是刺状投射神经元中线粒体、自噬和早期基因程序的调节因子：与亨廷顿舞蹈病转录变化的相关性
Stephanie N Fox,Cody H Savage,Narcy R Amireddy et al.
Stephanie N Fox et al.
While overexpression was sufficient to increase the expression of mitochondrial and lysosome-related transcripts, Esrrg deletion surprisingly caused increased expression of immediate-early genes and genes with enrichment of binding sites for transcriptional repressors.
Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus [0.03%]
脑的可塑性和细胞竞争： immediate early genes成为焦点
Pavel P Tregub,Yulia K Komleva,Maria V Kukla et al.
Pavel P Tregub et al.
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity o...
Brigitte van Zundert,Martin Montecino
Brigitte van Zundert
But what are the molecular mechanisms that govern the expression of immediate-early genes (IEGs; c-fos, Npas4) and plasticity-related genes (PRGs; Dlg4/PSD95 and Grin2b/NR2B) in memory ensemble?
Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation [0.03%]
Cd99l2调节兴奋性突触的发育并限制即时早期基因的激活
Minji Kang,Sang Ho Yoon,Minkyung Kang et al.
Minji Kang et al.
We demonstrate that Cd99l2 inversely regulates the expression of immediate-early genes (IEGs), including Arc, Egr1, and c-Fos, by inhibiting the activity of the transcription factors CREB and SRF.
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