Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy [0.03%]
用于银屑病就地化学光动力疗法的 topical 聚合物纳米系统同步递送血红素e6和HMGB1抑制剂甘草酸
Lijun Su,Yixi Zhu,Xuebo Li et al.
Lijun Su et al.
Recently, photodynamic therapy (PDT) has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis. Unfortunately, the activation of high mobility group box 1 protein (HMGB1) by PDT triggers innate and...
Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish [0.03%]
甘草酸联合治疗表现出神经保护作用并逆转斑马鱼帕金森病样病理症状
Qingyu Ren,Xin Jiang,Yam Nath Paudel et al.
Qingyu Ren et al.
Ethnopharmacological relevance: Parkinson's disease (PD) is the second most devastating age-related neurodegenerative diseases after Alzheimer diseases (AD) and is characterized by the loss of dopaminergic (DA) neurons in...
Naturally Occurring HMGB1 Inhibitor, Glycyrrhizin, Modulates Chronic Seizures-Induced Memory Dysfunction in Zebrafish Model [0.03%]
天然的HMGB1抑制剂甘草甜素通过调节慢性癫痫诱发的记忆损伤改善斑马鱼模型中的记忆功能障碍
Yam Nath Paudel,Shafi Ullah Khan,Iekhsan Othman et al.
Yam Nath Paudel et al.
Glycyrrhizin (GL) is a well-known pharmacological inhibitor of high mobility group box 1 (HMGB1) and is abundantly present in the licorice root (Glycyrrhiza radix). HMGB1 protein, a key mediator of neuroinflammation, has been implicated in ...
Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on post-contrast acute kidney injury [0.03%]
甘草酸对对比剂致急性肾损伤的保护作用与直接抑制HMGB1的关系
Hyewon Oh,Arom Choi,Nieun Seo et al.
Hyewon Oh et al.
Post contrast-acute kidney injury (PC-AKI) is defined as the deterioration of renal function after administration of iodinated contrast media. HMGB1 is known to play an important role in the development of acute kidney injury. The purpose o...
Glycyrrhizin, an HMGB1 inhibitor, Suppresses Interleukin-1β-Induced Inflammatory Responses in Chondrocytes from Patients with Osteoarthritis [0.03%]
甘草甜素通过抑制高迁移率族蛋白B1介导的白细胞介素-1β诱导的软骨细胞炎症反应治疗骨关节炎
Shifeng Zhou,Guodan Liu,Zhenxing Si et al.
Shifeng Zhou et al.
Background: High mobility group box 1 (HMGB1) is increased in osteoarthritis (OA) tissue and chondrocytes stimulated with interleukin-1β (IL-1β). Suppression of HMGB1 expression is correlated with reduced inflammatory r...
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin [0.03%]
甘草酸抑制HMGB1对缺氧缺血性脑病新生小鼠海马功能障碍的保护作用研究
Kai Le,Shanshan Wu,Enkhmurun Chibaatar et al.
Kai Le et al.
Hippocampal dysfunction related to cognitive impairment and emotional disorders in young children and adolescents caused by neonatal hypoxic-ischemic brain injury (HIBI) has attracted increasing attention in recent years. Crosstalk between ...
Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders [0.03%]
甘草甜素对神经系统疾病的潜在神经保护作用：抑制HMGB1的功效
Yam Nath Paudel,Efthalia Angelopoulou,Bridgette Semple et al.
Yam Nath Paudel et al.
Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza glabra, is a traditional medicine possessing a plethora of pharmacological anti-inflammatory, antioxidant, antimicrobial, and antiaging properties...
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus [0.03%]
甘草甜素通过抑制HMGB1发挥锂-匹罗卡品诱导的难治性颞叶癫痫小鼠模型中的神经保护作用
Ya-Jun Li,Lin Wang,Bei Zhang et al.
Ya-Jun Li et al.
Objectives: It has been proven that extracellular HMGB1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy. Glycyrrhizin (GL) is a direct inhibitor of HMGB1...
Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats [0.03%]
甘草甜素对大鼠局灶性脑缺血再灌注损伤炎症、氧化应激及凋亡的HMGB1通路抑制效应研究
Gu Gong,Lei Xiang,Libang Yuan et al.
Gu Gong et al.
Aim: Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In the present study, the protective effe...
Inhibition of neointimal hyperplasia in the rat carotid artery injury model by a HMGB1 inhibitor [0.03%]
HMGB1抑制剂在阻抑大鼠颈动脉损伤模型中平滑肌细胞过度增殖的作用及机制研究
Jing Chen,Jing Zhang,Lin Xu et al.
Jing Chen et al.
Objective: High mobility group box 1 protein (HMGB1) is expressed in atherosclerotic lesions. However, its role in vascular system is unknown. In this study, we explore whether the inhibition of HMGB1 attenuates neointima...
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