Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies [0.03%]
并行的HIV-1适应度景观塑造了产生广泛中和抗体的人类和猕猴体内的病毒动态变化
Kai S Shimagaki,Rebecca M Lynch,John P Barton
Kai S Shimagaki
Human immunodeficiency virus (HIV)-1 exhibits remarkable genetic diversity. For this reason, an effective HIV-1 vaccine must elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) hav...
HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies [0.03%]
逃逸VRC01型CD4结合部位中和抗体相关的HIV-1适应性下降
Rebecca M Lynch,Patrick Wong,Lillian Tran et al.
Rebecca M Lynch et al.
Broadly neutralizing antibodies (bNAbs) have been isolated from selected HIV-1-infected individuals and shown to bind to conserved sites on the envelope glycoprotein (Env). However, circulating plasma virus in these donors is usually resist...
Estimating HIV-1 fitness characteristics from cross-sectional genotype data [0.03%]
利用横断面基因型数据估计HIV-1的适应性特征
Sathej Gopalakrishnan,Hesam Montazeri,Stephan Menz et al.
Sathej Gopalakrishnan et al.
Despite the success of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance development remains a major challenge. Resistant mutants dis...
HIV-1 fitness landscape models for indinavir treatment pressure using observed evolution in longitudinal sequence data are predictive for treatment failure [0.03%]
基于观察到的序列纵向数据进化的HIV-1耐药性拟合模型可预测印地那韦治疗失败
Raphael Z Sangeda,Kristof Theys,Gertjan Beheydt et al.
Raphael Z Sangeda et al.
We previously modeled the in vivo evolution of human immunodeficiency virus-1 (HIV-1) under drug selective pressure from cross-sectional viral sequences. These fitness landscapes (FLs) were made by using first a Bayesian network (BN) to map...
Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome [0.03%]
免疫逃逸突变在同源传染/创始基因组环境下的HIV-1适应性影响分析
Hongshuo Song,Jeffrey W Pavlicek,Fangping Cai et al.
Hongshuo Song et al.
Background: A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations s...
Michael J Dapp,Richard H Heineman,Louis M Mansky
Michael J Dapp
Differences in replication fidelity, as well as mutator and antimutator strains, suggest that virus mutation rates are heritable and prone to natural selection. Human immunodeficiency virus type 1 (HIV-1) has many distinct advantages for th...
Roger D Kouyos,Gabriel E Leventhal,Trevor Hinkley et al.
Roger D Kouyos et al.
Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci o...
vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments [0.03%]
vFitness：一种基于网络的计算工具 可改善体外HIV-1适应度实验的测定结果
Jingming Ma,Carrie Dykes,Tao Wu et al.
Jingming Ma et al.
Background: The replication rate (or fitness) between viral variants has been investigated in vivo and in vitro for human immunodeficiency virus (HIV). HIV fitness plays an important role in the development and persistenc...
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness [0.03%]
基于结构的整合酶-LEDGF / p75界面变体筛选揭示了体外蛋白相互作用与HIV-1适应度之间的严格相关性被解离
Shaila Rahman,Richard Lu,Nick Vandegraaff et al.
Shaila Rahman et al.
LEDGF/p75 binding-defective IN mutant viruses were previously characterized as replication-defective, yet RNAi did not reveal an essential role for the host factor in HIV-1 replication. Correlative analyses of protein binding and viral fitn...
HIV-1 fitness and disease progression: insights from the SIV-macaque model [0.03%]
艾滋病病毒(HIV-1)适应性的致病性及其发病机制：取自猴模型的见解
Jason T Kimata
Jason T Kimata
Within the initial weeks following transmission, HIV-1 becomes well established in the lymphatic tissue reservoir. Replication of the virus occurs throughout the course of infection despite the induction of a vigorous adaptive immune respon...
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