HIV-1 envelopes from virions that persist in plasma on antiretroviral therapy show reduced susceptibility to autologous immunoglobulins and variable sensitivity to broadly neutralizing monoclonal antibodies [0.03%]
抗逆转录病毒治疗后持续存在于血浆的 HIV-1 衣壳显示出对自身免疫球蛋白的减少敏感性及对广谱单克隆抗体多变的敏感度
Savrina Manhas,Joseph P Brooker,Cory Shetler et al.
Savrina Manhas et al.
Despite adherence to antiretroviral therapy (ART), low levels of plasma virus persist in most individuals with HIV-1. In a small subset of these individuals, this non-suppressible viremia is detected by routine clinical testing (plasma HIV-...
Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance [0.03%]
HIV-1包膜在HVTN703 / HPTN081试验中的多谱系感染中区分具有不同VRC01表型的抗药性突变及其交叉耐药性的含义
Paula Cohen,Bronwen E Lambson,Nonhlanhla N Mkhize et al.
Paula Cohen et al.
The Antibody Mediated Prevention (AMP) trials showed that passively infused VRC01, a broadly neutralizing antibody (bNAb) targeting the CD4 binding site (CD4bs) on the HIV-1 envelope protein (Env), protected against neutralization-sensitive...
Correction: Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation [0.03%]
纠正：Kennedy表位（KE）依赖的高效裂解HIV-1包膜蛋白（Env）的逆向运输及其对Env细胞表面表达和病毒粒子形成的影响
Supratik Das,Hilal Ahmad Parray,Adarsh Kumar Chiranjivi et al.
Supratik Das et al.
Published Erratum
The protein journal. 2024 Apr;43(2):387-392. DOI:10.1007/s10930-023-10172-y 2024
Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation [0.03%]
肯尼迪决定簇(KENNDY EPITOPE)(KE)依赖的HIV-1包膜(ENVIRONMENTS)(Envs)高效切割后的逆向运输及其对Env细胞表面表达和病毒颗粒形成的影响
Supratik Das,Hilal Ahmad Parray,Adarsh Kumar Chiranjivi et al.
Supratik Das et al.
Efficiently cleaved HIV-1 Envs are the closest mimics of functional Envs as they specifically expose only bNAb (broadly neutralizing antibody) epitopes and not non-neutralizing ones, making them suitable for developing vaccine immunogens. W...
Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses [0.03%]
基于来自早期广谱中和反应患者的HIV-1包膜的类病毒颗粒免疫原对包膜特异性抗体反应的强大诱导作用
Carolina Beltran-Pavez,Ilja Bontjer,Nuria Gonzalez et al.
Carolina Beltran-Pavez et al.
Longitudinal studies in HIV-1-infected individuals have indicated that 2 to 3 years of infection are required to develop broadly neutralizing antibodies. However, we have previously identified individuals with broadly neutralizing activity ...
Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations [0.03%]
HIV-1 envelopes糖蛋白突变抗病毒机制分析研究
Yuta Hikichi,Rachel Van Duyne,Phuong Pham et al.
Yuta Hikichi et al.
Despite the effectiveness of antiretroviral (ARV) therapy, virological failure can occur in some HIV-1-infected patients in the absence of mutations in drug target genes. We previously reported that, in vitro, the lab-adapted HIV-1 NL4-3 st...
Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development? [0.03%]
高效切割的HIV-1包膜蛋白与疫苗抗原研发之间的关系
Supratik Das,Rajesh Kumar,Shubbir Ahmed et al.
Supratik Das et al.
The enormous diversity of HIV-1 is a significant impediment in selecting envelopes (Envs) that can be suitable for designing vaccine immunogens. While tremendous progress has been made in developing soluble, trimeric, native-like Env protei...
Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes [0.03%]
用于筛选 transmit/founder 型 subtype C HIV-1 衣壳的SHIV的理性设计和体内选择
Sean P O&#x;Brien,Adrienne E Swanstrom,Amarendra Pegu et al.
Sean P O&#x;Brien et al.
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Fur...
Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail [0.03%]
一个保守的富含亲水性氨基酸残基区段对于决定HIV-1病毒进入功能的一小部分衣壳外衣壳亚群的细胞表面结构域完整性是必需的
Sweety Samal,Supratik Das,Saikat Boliar et al.
Sweety Samal et al.
Background: HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The cleaved, native, trimeric form of Envs expose...
Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes [0.03%]
用传递/始祖克隆C人类免疫缺陷病毒包膜感染猴子
Mohammed Asmal,Corinne Luedemann,Christy L Lavine et al.
Mohammed Asmal et al.
Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder (T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman primates. Currently available SHIVs contain HIV-1 env genes from ch...
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