Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy [0.03%]
BAY 3389934盐酸盐的发现：一种有效且具有选择性的短半衰期小分子二因子IIa/Xa抑制剂，用于急性治疗脓毒症引起的凝血障碍
Hartmut Beck,Stefanie Mesch,Stefanie Zimmermann et al.
Hartmut Beck et al.
Herein, we describe the discovery of BAY 3389934 hydrochloride (31), a potent and highly selective, direct dual FIIa/Xa inhibitor, with high solubility suited for i.v. application.
Ag(I) induced H-type and Pd(II) induced J-type phthalocyanines to enhance PDT applications: synthesis, optical behaviors, photochemical/photophysical properties, and DFT studies [0.03%]
银(I)诱导H型和钯(II)诱导J型的酞菁合成、光学行为、光化学/光物理性质及DFT研究以增强PDT应用
Tenzile Alagöz,Hayriye Genç Bilgiçli,Elif Polat et al.
Tenzile Alagöz et al.
The substitution with the thiol group of phthalocyanine molecules gives them high solubility features in organic solvents. Thus, the effect of self-aggregation behaviors on electronic spectra was determined in organic solvent media.
A Green Cellulose Dissolution System for Producing Tunable Regenerated Nanocellulose Formate [0.03%]
一种绿色的纤维素溶解体系以制备可调式再生纳米纤维素甲酸酯
Yidong Zhang,Wangfang Deng,Zengbin Wang et al.
Yidong Zhang et al.
This method yields a high solubility (up to 10 wt %) of cellulose, which consequently facilitates the preparation of tunable regenerated nanocellulose formate (RNCF) with versatile applications.
Role of Environmental Photocatalysts and Organic Matter on the Degradation and Toxicity of Metformin Hydrochloride [0.03%]
光催化剂和有机物对盐酸二甲双胍降解及毒性的影响作用研究
Rifat Khan,Jaqueline Regalado,Malsha Indeewari Kanaththage et al.
Rifat Khan et al.
It is a leading drug regarding mass distribution, and its high solubility in water leads to its significant accumulation in surface and groundwater.
Application of edible films from fermented Opuntia cochenillifera mucilage in the preservation of minimally processed fruits [0.03%]
仙人掌果胶发酵可食性膜在果蔬保鲜中的应用研究
Shênia Santos Monteiro,Antônia Isabelly Monteiro Dos Anjos,Anna Clara Batista de Sousa et al.
Shênia Santos Monteiro et al.
The MOCF-S film showed high solubility (96.43 %), greater water vapor permeability (6.13 g/kPa h m2), and a smooth and uniform surface, suggesting compatibility between fermented mucilage and starch.
Highly soluble and well-defined polysaccharide-based micelle in aqueous media: Decyl succinic anhydride-modified pullulan [0.03%]
水溶性好的定义明确的基于多糖的胶束：癸基琥珀酸酐修饰的糊精钠盐
Risa Suenaga,Yuzu Komuro,Ken Terao
Risa Suenaga
These features, namely the well-defined micelle structure and high solubility in aqueous media without large aggregates, indicate potential applications in drug delivery systems and as food additives.
Harnessing the Potential of 5-Hydroxymethylfurfural: Investigating Solubility and Stability in Tailored Deep Eutectic Solvents [0.03%]
5-羟甲基糠醛在定制深共晶溶剂中的溶解度和稳定性研究
Grazia Isa C Righetti,Maria Enrica Di Pietro,Gabriella Leonardi et al.
Grazia Isa C Righetti et al.
Our findings reveal that HMF demonstrates high solubility and remarkable stability across the studied DES. Only a few cases of HMF degradation were observed and discussed, with specific degradation pathways identified in certain solvent mixtures.
Complex Iridate Solid Solutions for Catalyzing Oxygen Evolution Reaction: Comparison of Elemental Leaching and Stability Numbers [0.03%]
用于催化析氧反应的复杂铱酸盐固溶体：元素浸出与稳定数的比较
Ki Hyun Park,Younghwan Lim,Hyung Bin Bae et al.
Ki Hyun Park et al.
Consequently, achieving high solubility of foreign elements in Ir-based solid-solution oxides has been significantly limited.
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties [0.03%]
含龙葵素纳米颗粒的抗肿瘤和抑制转移效果及作为乳腺癌治疗新策略的潜在作用力评估研究
Nadia Zargarani,Mahsa Kavousi,Elahe Aliasgari
Nadia Zargarani
We synthesized optimized niosome NPs (NPs) with high solubility and capacity for solanine loading. In this study, the cytotoxic, cell cycle inhibitory and apoptotic effects of solanine-loaded niosome NPs (SN-NPs) on MCF-7 were investigated.
A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy [0.03%]
一种能够高效递送高亲水性及亲脂性的天然化合物以增强溃疡性结肠炎治疗的双载药体系
Yueqian Wu,Yuting Jiang,Yihao He et al.
Yueqian Wu et al.
Bigel, formed by high-speed shearing of hydrogel and oleogel, is suited to deliver both lipophilic and hydrophilic active compounds. patchouli oil and paeoniflorin, despite their potential in treating ulcerative colitis, face challenges due to patchouli oil's poor aqueous solubility and paeoniflorin's high...solubility but low permeability.
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