Vehicle-specific toxicological profiles of tire wear particles: Physiological, microbial, and transcriptomic disruptions in zebrafish induced by light and heavy-duty vehicle emissions [0.03%]
轮胎磨损颗粒的车辆特异性毒理学特征：轻型和重型汽车排放物对斑马鱼生理、微生物和转录组的干扰
Qingxuan Meng,Qianqian Song,Xinrui Meng et al.
Qingxuan Meng et al.
Here, we comprehensively evaluated physiological responses, gut microbiota alterations, and liver transcriptomic changes in zebrafish exposed to HTWPs and LTWPs. Scanning electron microscopy (SEM) analysis revealed that HTWPs exhibit rougher surfaces and sharper edges compared to LTWPs.
Biological gender difference of bile acid metabolism in susceptibility to cholelithiasis in patients with nonalcoholic fatty liver disease [0.03%]
非酒精性脂肪性肝病患者胆汁淤积易感性的性别差异及胆酸代谢机制研究
Ya Wang,Dazhang Deng,Meiqing Mai et al.
Ya Wang et al.
Serum and fecal BA profiles were analyzed, along with a correlation analysis of gut microbiota composition. Gender-specific divergence in hydrophobic BAs distribution was observed, with females exhibiting significantly higher serum retention....Additionally, the total abundance of Fusobacterium and Escherichia-Shigella in the gut microbiota was elevated in females....Overall, BAs and gut microbiota exhibit gender dimorphism in NAFLD patients, which may be linked to the increased risk of secondary GSD in women.
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial [0.03%]
动物双歧杆菌亚种乳杆菌BL-99和低聚果糖对功能性便秘老年人的效果及持续性：随机、双盲、安慰剂对照试验
Meina Li,Qi Zhang,Wen Zhao et al.
Meina Li et al.
These findings demonstrate that BL-99/FOS supplementation ameliorates FC symptoms in older adults, with effects sustained post-discontinuation, potentially mediated through gut microbiota modulation.
Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency [0.03%]
通过Akkermansia菌属补充调节肠道微生物群可增强CAR-T细胞的效力
Laura Marcos-Kovandzic,Michele Avagliano,Myriam Ben Khelil et al.
Laura Marcos-Kovandzic et al.
This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 CAR-T cell therapy, both in patients and in a preclinical syngeneic tumor model. B cell lymphoma patients treated with CD19-...
Fruit flies exploit behavioral fever as a defense strategy against parasitic insects [0.03%]
果蝇利用行为性发热作为防御寄生虫的策略
Yifeng Sheng,Zixuan Xu,Yang Li et al.
Yifeng Sheng et al.
We further find that behavioral fever up-regulates immune genes in infected hosts, including 12 antimicrobial peptide (AMP) genes, which disrupt the gut microbiota homeostasis of parasitoid wasps and, in turn, lead to substantial wasp mortality.
Marthe Tofthagen,Chunsheng Jin,Piyush Patel et al.
Marthe Tofthagen et al.
The interactions between intestinal mucins and the gut microbiota significantly influence digestive processes, metabolic activities, and pathogen resistance in the gastrointestinal tract.
Functionalized Silver Nanoparticles as Multifunctional Agents Against Gut Microbiota Imbalance and Inflammation [0.03%]
功能性银纳米颗粒作为治疗肠道菌群失调和炎症的多功能剂
Mihaela Stoyanova,Vera Gledacheva,Miglena Milusheva et al.
Mihaela Stoyanova et al.
The current study aims to assess the antimicrobial and antifungal effects of drug-loaded silver nanoparticles (AgNPs) with previously reported mebeverine analogue (MA) as a potential drug candidate targeting gut microbiota and inflammation in the gastrointestinal tract.
Unlocking the potential of the low FODMAP diet: comprehensive insights into clinical efficacy, microbiome modulation, and beyond [0.03%]
解锁低FODMAP饮食的潜力：全面深入了解其临床疗效、微生物组调节等各方面的问题
Fernanda Cristofori,Stefania Castellaneta,Costantino Dargenio et al.
Fernanda Cristofori et al.
Particular attention is given to emerging insights into its impact on gut microbiota and long-term safety.
High-Pressure and Thermal Pasteurization Applied to Smoothies Enhances (Poly)Phenol Bioaccessibility along the Gastrointestinal Tract [0.03%]
高压和热巴氏杀菌处理 smoothie 可增强肠道中植物化学物的生物可及性
Cristina Matías,Gema Pereira-Caro,María-José Sáiz-Abajo et al.
Cristina Matías et al.
Native (poly)phenols were almost completely converted (83-87%) into low-molecular-weight catabolites by the gut microbiota in all smoothies.
Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation [0.03%]
咖啡酸苯乙酯通过抑制毒素和调节微生物群保护艰难梭菌感染
Yan Guo,Yong Zhang,Guizhen Wang et al.
Yan Guo et al.
The disruption of normal gut microbiota by the use of broad-spectrum antimicrobial agents enables C. difficile to proliferate in the colon....Moreover, CAPE treatment of C. difficile-challenged mice induces a remarkable increase in the diversity and composition of the gut microbiota and alterations of gut metabolites (e.g., adenosine, D-proline, and melatonin), which might partially contribute to the therapeutic outcomes of CAPE against CDI
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