Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X [0.03%]
自闭症风险基因DDX3X的突变引起的性别特异性神经发育障碍
Adele Mossa,Lauren Dierdorff,Jeronimo Lukin et al.
Adele Mossa et al.
Further, ablating Ddx3x conditionally in forebrain neurons is sufficient to yield sex-specific changes in developmental outcomes and motor function.
Impaired synaptic plasticity in behaving mice by inactivation of presenilin and accumulation of the neurexin gamma-secretase proteolytic substrate [0.03%]
通过失活早老素和积累神经蛋白γ分泌酶蛋白水解底物抑制小鼠的突触可塑性
Francisco Arias-Aragón,Ana C Sánchez-Hidalgo,Agnès Gruart et al.
Francisco Arias-Aragón et al.
In contrast, PScKOtam mice lacking Psen1/2 genes in forebrain neurons in a tamoxifen-regulated manner show decreased paired-pulse facilitation at mPFC-BLA synapse along with impaired memory. Neurexins (Nrxns) are presynaptic membrane proteins processed by PS/gamma-secretase.
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice [0.03%]
胶质 Derived 的大脑神经元中的FKBP51促进雌性小鼠早期生命压力适应
Lotte van Doeselaar,Alexandra Abromeit,Tibor Stark et al.
Lotte van Doeselaar et al.
Here, the contribution of FKBP51 in glutamatergic forebrain neurons to the long-term consequences of ELS was investigated in both sexes.
Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice [0.03%]
prolactin介导的泌乳引起的下丘脑弓核kisspeptin神经元活性抑制作用是小鼠泌乳性不孕所必需的
Eleni Hackwell,Sharon R Ladyman,Jenny Clarkson et al.
Eleni Hackwell et al.
Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in failure to maintain normal lactation-induced suppression of estrous cycles.
Impaired Basal Forebrain Cholinergic Neuron GDNF Signaling Contributes to Perioperative Sleep Deprivation-Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy [0.03%]
基底前脑胆碱能神经元GDNF信号通路受损通过调节胆碱能神经元活性、凋亡及自噬参与围术期睡眠剥夺诱发的小鼠术后慢性痛异化形成
Dong Wang,Shi-Nan Wei,Lu Zhang et al.
Dong Wang et al.
deprivation (6 h per day from -1 to 3 days postoperatively) was administered to mice receiving skin/muscle incision and retraction (SMIR) to determine whether perioperative sleep deprivation induces mechanical and thermal pain hypersensitivity, increases the risk of chronic pain, and causes changes of basal forebrain...neurons activity (c-Fos immunostaining), apoptosis (cleaved Caspase-3 expression), autophagy (LC3 and p62 expression) and GDNF expression.
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X [0.03%]
自闭症风险基因DDX3X的突变引起的神经元发育性别特异性异常
Adele Mossa,Lauren Dierdorff,Jeronimo Lukin et al.
Adele Mossa et al.
Further, ablating Ddx3x conditionally in forebrain neurons is sufficient to yield sex-specific changes in developmental outcomes and motor function.
Biochemical Properties of Synaptic Proteins Are Dependent on Tissue Preparation: NMDA Receptor Solubility Is Regulated by the C-Terminal Tail [0.03%]
突触蛋白的生化特性依赖于组织制备方式：N-甲基-D天冬氨酸受体溶解性由C端尾调控
Sehoon Won,Colin L Sweeney,Katherine W Roche
Sehoon Won
To evaluate the efficiency of several common solubilization conditions, we isolated receptors, scaffolding proteins, and adhesion molecules from brain tissue or primary cultured neurons or human forebrain neurons differentiated from induced pluripotent stem cells (iPSCs)....We found that N-methyl-d-aspartate receptors (NMDARs) and PSD-95 are relatively insoluble in brain tissue, cultured neurons, and human forebrain neurons compared to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptors (AMPARs) or SAP102....In general, synaptic proteins were more soluble in primary neuronal cultures and human forebrain neurons compared to brain tissue.
ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75NTR and induction of amyloid precursor protein [0.03%]
通过p75NTR和诱导淀粉样前体蛋白诱发基底前脑神经元轴突逆行退行化
Srestha Dasgupta,Mansi A Pandya,Juan P Zanin et al.
Srestha Dasgupta et al.
Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple regions in the brain to regulate cognitive functions. Degeneration of BFCNs is seen with aging, after brain injury, and in neurodegenerative disorders. An incre...
Social and auditory experience shapes forebrain responsiveness in zebra finches before the sensitive period of vocal learning [0.03%]
社交和听觉体验在条纹 Finch 模式学习敏感期之前塑造前脑反应性
Katie M Schroeder,Luke Remage-Healey
Katie M Schroeder
Auditory forebrain neurons in cross-fostered and isolated birds showed increases in firing rate and decreases in responsiveness and selectivity.
A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental syndrome demonstrates the role of histone H3.3 in neuronal differentiation and maturation [0.03%]
布莱恩特-李-布霍神经发育综合征的新iPSC模型展示了组蛋白H3.3在神经元分化和成熟中的作用
Annabel K Sangree,Rajesh Angireddy,Laura M Bryant et al.
Annabel K Sangree et al.
Methods: Here, we investigate how one BLBS-causative variant, H3-3B p.Leu48Arg (L48R), affects neurodevelopment using an induced pluripotent stem cell (iPSC) model differentiated to 2D neural progenitor cells (NPCs), 2D forebrain neurons (FBNs), and 3D dorsal forebrain organoids (DFBOs
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