Debate 2: Primary Localized Prostate Cancer: The Case for Whole-Gland Brachytherapy Boost [0.03%]
局部前列腺癌的辩论：全腺体近距离放疗 boost 的理由
Amani A Chowdhury,Peter J Hoskin
Amani A Chowdhury
Similarly, many studies have used various EBRT techniques to deliver boost treatment despite the radiobiological advantages and stronger evidence base advocating for BT.
Rethinking balanced food supplementation for pregnant women: time to move beyond energy and protein [0.03%]
重新思考孕妇平衡膳食补充：超越能量和蛋白质的时候到了
Kathryn G Dewey,Sonja Y Hess,Nancy J Krebs et al.
Kathryn G Dewey et al.
BEP supplementation is recommended for undernourished populations by the World Health Organization, although the evidence base for this includes highly heterogeneous products and comparison groups....In this Perspective, we briefly outline limitations in the evidence base for BEP supplementation and argue that the term diverts attention away from other important elements of "balance", such as healthy fats and carbohydrates.
High Economic Burden Yet Low Clinical Value: Why Is so Much Sucralfate Prescribed? [0.03%]
经济负担高但临床价值低：为什么那么多患者在使用硫糖铝？
Neha Wadhavkar,Laura Varnum,Steven F Moss
Neha Wadhavkar
We reviewed the limited evidence base supporting the approval and ongoing usage of sucralfate and performed a cost analysis using the ClinCalc database. The financial impact of sucralfate was comparable to famotidine, lansoprazole and ranitidine.
A scoping review of program evaluations in non-profit alcohol and other drugs service settings: Considerations for service and research partnerships [0.03%]
非营利性酒精和其他药物服务机构项目评价的范围审查：服务与研究合作考虑事项
Emily Deans,George Economidis,Peter Gates et al.
Emily Deans et al.
Specifically, such evaluations should generate knowledge which can be translated into practice, demonstrating the impact of services and programs and an evidence base built in the non-profit sector.
Identifying and mitigating the biological effectors of the social determinants of health in cancer [0.03%]
识别并减轻癌症社会决定因素的生物学效应
Monica Wagner,Christopher L Benson nd,Samilia Obeng-Gyasi et al.
Monica Wagner et al.
Workshop presentations and discussions provided an overview of biological effectors and SDOH; emerging research in these areas, including the development and validation of biomarkers and strategies to improve the evidence base for monitoring, diagnosing, policy, research, and clinical practice opportunities
Melinda DiCiro,Melanie Scott
Melinda DiCiro
A Systematic Review of Contemporary and Emerging Analgesia Techniques for Natural Labor-Patient-Centered Approaches and Technological Advances [0.03%]
当代与新兴自然分娩镇痛技术的系统评价——以病人为中心的方法和科技进展
Marta Bonarska,Damian Adasik,Simone Szymczyk et al.
Marta Bonarska et al.
Limitations: The evidence base exhibited variability in study quality, sample sizes, and reporting. The absence of standardized outcome measures, a lack of meta-analyses, and limited data on long-term outcomes limit the robustness and generalizability of the conclusions that can be drawn.
Now and the Future: Medications Changing the Landscape of Cardiovascular Disease and Heart Failure Management [0.03%]
当前与未来：心血管疾病和心力衰竭治疗领域的药物变革
Thomas Oswald,Steven Coombs,Susan Ellery et al.
Thomas Oswald et al.
This review article aims to discuss these three main drug classes (SGLT2 inhibitors, GLP-1RAs and non-steroidal MRAs) in detail by exploring their current evidence base across heart failure (HF) and CVD management and future clinical implications of their usage as mainstream medical therapies.
The Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four Prospective Clinical Trials Performed Across the UK and Ireland [0.03%]
术前康复对食管胃结合部癌手术患者预后影响的meta分析：英国及爱尔兰四家医院前瞻性临床试验数据的汇总分析
Sowrav Barman,Beth Russell,Robert C Walker et al.
Sowrav Barman et al.
Current initiatives to agree on national standards for delivering prehabilitation and the results of ongoing trials will help to further refine this important intervention and expand the evidence base to support the widespread adoption and implementation of prehabilitation programs.
Emerging and accumulating safety signals for the use of estrogen among transgender women [0.03%]
跨性别女性使用雌激素的新兴和累积的安全信号
Lauren Schwartz,M Lal,J Cohn et al.
Lauren Schwartz et al.
There is an urgent need for the evidence base to be improved with more studies, especially those with systematic long-term follow-up and those that can disentangle possible confounders, as well as systematic reviews to help interpret their reliability.
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