Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters [0.03%]
白癜风的临床异质性：基于患者分群的临床标志物识别
Laura Galissi,Tristan Benoît,Ribal Merhi et al.
Laura Galissi et al.
Although vitiligo has been delineated previously, the endophenotypes of the disease are still to be defined.
Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development [0.03%]
五羟色胺转运蛋白基因失活扰乱雄性大鼠产后发育前期背侧前额叶皮层神经递质受体基因及全基因组DNA甲基化水平表达模式
Yvet Kroeze,Martin Oti,Roel H M Cooijmans et al.
Yvet Kroeze et al.
Reduced expression of the serotonin transporter (5-hydroxytryptamine transporter, 5-HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood.
Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders [0.03%]
神经影像内表型揭示四种脑疾病进展和发展背后的潜在机制和遗传因素
Junhao Wen,Ioanna Skampardoni,Ye Ella Tian et al.
Junhao Wen et al.
Recent work leveraging artificial intelligence has offered promise to dissect disease heterogeneity by identifying complex intermediate brain phenotypes, called dimensional neuroimaging endophenotypes (DNEs).
Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi-Ethnic Study of Atherosclerosis [0.03%]
动脉粥样硬化的多种族研究对认知的影响：脑小血管病的全球影响评估
Sokratis Charisis,Tanweer Rashid,Christina Dintica et al.
Sokratis Charisis et al.
Discussion: Integrating multiple individual SVD endophenotypes may more accurately reflect the neurobiology of SVD and capture its global impact on cognition....We modeled small vessel disease as a latent construct, integrating multiple MRI endophenotypes in strategic brain regions. The small vessel disease construct was associated with worse global and domain-specific cognitive performance....Integrating information from multiple relevant imaging endophenotypes could open new avenues in small vessel disease research, broadening our understanding of its risk factors and clinical correlates.
Lung functions and IgE component sensitizations: Five wheezing phenotypes in adolescents from the T-Child study in Tokyo [0.03%]
东京T-_CHILD研究中青少年五种喘息表型的肺功能和Ige组分敏感性分析
Kiwako Yamamoto-Hanada,Limin Yang,Mayako Saito-Abe et al.
Kiwako Yamamoto-Hanada et al.
Background: The endophenotypes of allergic disorders are known to vary across racial groups, underscoring the importance of studying allergic disease phenotypes in the population of Tokyo.
Metabolomic endophenotypes based on oxo-eicosatetraenoic acids in patients with aspirin-exacerbated respiratory disease [0.03%]
基于氧二十碳四烯酸的代谢内型在阿司匹林加重呼吸道疾病患者中的作用
Piotr Szatkowski,Adam Stępień,Adam Ćmiel et al.
Piotr Szatkowski et al.
Background: Arachidonic acid (AA) metabolism in patients with aspirin-exacerbated respiratory disease (AERD) is characterized by an imbalance between proinflammatory and anti-inflammatory eicosanoids. In this study, we fo...
The use of different types of networks, alone and in combination, for drug target identification [0.03%]
单独或联合使用不同类型网络进行药物靶点识别的方法
Paolo Parini
Paolo Parini
Network Medicine plays a vital role in understanding diseases by identifying key endophenotypes and determinants influencing disease expression.
Distribution of red blood cell fatty acids in stable patients with a schizophrenia spectrum disorder and healthy controls [0.03%]
精神分裂症谱系障碍稳定期患者和健康对照组的红细胞脂肪酸分布状况
Gwendolyn Schoemaker,Roel J T Mocking,Suzanne Medema et al.
Gwendolyn Schoemaker et al.
Bimodality suggests subgroups of the disease, including different endophenotypes and/or clinical characteristics. However, to date only a small number of publications reported on bimodality.
Endophenotype-Informed Association Analyses for Liver Fat Accumulation and Metabolic Dysfunction in the Fels Longitudinal Study [0.03%]
基于内表型的肝脂肪蓄积和代谢功能障碍关联分析——弗尔斯纵向研究结果
Ariana L Garza,John Blangero,Miryoung Lee et al.
Ariana L Garza et al.
This study aimed to identify potential endophenotypes for liver fat content and employ them in bivariate linkage searches for pleiotropic genetic regions where targeted association analysis is more likely to reveal significant variants....The top-ranked endophenotypes were then used in a bivariate linkage analysis, paired with liver fat content. Quantitative trait loci (QTLs) identified as significant or suggestive were targeted for measured genotype association analyses....The highest-ranked endophenotypes for liver fat accumulation were insulin resistance (IR), visceral adipose tissue (VAT), and high-density lipoprotein cholesterol (HDL-C).
[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry] [0.03%]
[自杀意念和行为：一种面向精准精神病学的跨诊断维度]
Aiste Lengvenyte,Émilie Olié,Marion Leboyer et al.
Aiste Lengvenyte et al.
This specificity is supported by genetic studies, biomarkers, and preclinical research on endophenotypes associated with suicidal behaviors, such as impulsivity, anhedonia, and hopelessness.
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