Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens [0.03%]
小鼠伏隔核多巴胺编码未来的防御行为
Austen A Fisher,L Sofia Gonzalez,Zoe R Cappel et al.
Austen A Fisher et al.
Dopamine release in the nucleus accumbens (NAc) plays a critical role in the motivation to perform actions that promote survival. However, the NAc dopamine response to innately threatening visual stimuli, such as predators descending from a...
Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation [0.03%]
内源性大麻素水平的慢性增强持续增加多巴胺奖赏成本和动机编码
Dan P Covey,Edith Hernandez,Miguel Á Luján et al.
Dan P Covey et al.
encoding of prior reward cost, providing critical insight into the neurobiological mechanisms of a viable treatment for motivational deficits.SIGNIFICANCE STATEMENT Decades of work has established a fundamental role for dopamine neurotransmission in motivated behavior and cue-reward learning, but how dopaminergic...encoding of cues associates with motivated action has remained unclear.
Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction [0.03%]
成瘾相关厌恶刺激的多巴胺信号及其投射特异性神经机制研究进展
Kimberly C Thibeault,Munir Gunes Kutlu,Christina Sanders et al.
Kimberly C Thibeault et al.
Drug addiction is a major public health concern across the world for which there are limited treatment options. In order to develop new therapies to correct the behavioral deficits that result from repeated drug use, we need to understand t...
Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost [0.03%]
纹状体多巴胺D2受体调节的是决策付出的努力而不是决策的价值，并改变多巴胺对成本的编码
Ina Filla,Matthew R Bailey,Elke Schipani et al.
Ina Filla et al.
Deficits in goal-directed motivation represent a debilitating symptom for many patients with schizophrenia. Impairments in motivation can arise from deficits in processing information about effort and or value, disrupting effective cost-ben...
Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease [0.03%]
细胞内大麻素降解抑制可纠正Q175亨廷顿舞蹈病小鼠模型中的动机和多巴胺能缺陷
Dan P Covey,Hannah M Dantrassy,Samantha E Yohn et al.
Dan P Covey et al.
Here, we show that dopaminergic encoding of effortful drive progressively declines with age in an HD mouse model, and is restored by elevating tissue levels of the eCB 2-arachidonoylglycerol (2-AG) through targeted inhibition of its enzymatic degradation....This work supports aberrant dopaminergic encoding of reward as a neurobiological correlate of apathy in HD, and indicates that cannabinoid receptor-based therapies may benefit neuropsychiatric care for HD.
Corticosterone regulates both naturally occurring and cocaine-induced dopamine signaling by selectively decreasing dopamine uptake [0.03%]
皮质酮通过选择性减少多巴胺再摄取来调节自然发生的和可卡因引起的多巴胺信号转导
Daniel S Wheeler,Amanda L Ebben,Beliz Kurtoglu et al.
Daniel S Wheeler et al.
However, a second experiment indicated that the same injection of corticosterone had no detectable effect on the dopaminergic encoding of a palatable natural reward (saccharin).
Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease [0.03%]
多巴胺能编码奖赏能力下降伴克服高昂代价意愿降低是亨廷顿舞蹈病Q175小鼠模型的显著前驱特征
Dan P Covey,Hannah M Dantrassy,Natalie E Zlebnik et al.
Dan P Covey et al.
This compromised dopaminergic encoding of reward delivery coincident with suppressed motivation to work for reward in Q175 mice provides novel, neurobiological insight into an established and clinically relevant endophenotype of prodromal HD.