Donor-Derived Cell-Free DNA for Diagnosing Subclinical Rejection: A Pilot Multicenter Study in Japanese Living-Donor Kidney Transplantation [0.03%]
供者来源的无细胞DNA诊断日本活体供肾移植受者的亚临床排斥反应：一项多中心研究试点研究
Toshihito Hirai,Taro Banno,Kazuya Omoto et al.
Toshihito Hirai et al.
Background: Donor-derived cell-free DNA (dd-cfDNA) offers a non-invasive biomarker for detecting allograft injury. However, its performance in predominantly living-donor transplant settings in Asian populations remains un...
Multicenter Study
Clinical transplantation. 2025 Jul;39(7):e70221. DOI:10.1111/ctr.70221 2025
Urinary and plasma donor-derived cell-free DNA for noninvasive monitoring of BK polyomavirus-associated nephropathy in kidney transplant recipients: a prospective cohort study [0.03%]
尿源性和血浆来源的游离DNA用于非侵入性监测肾移植受者的BK多瘤病毒相关性肾病：一项前瞻性队列研究
Luying Guo,Sulin Luo,Rongfang Shen et al.
Luying Guo et al.
Background: BK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of allograft injury and dysfunction in kidney transplant recipients. Current monitoring tools, including viremia and biopsy, have limitations i...
Increased Donor-Derived Cell-Free DNA as a Predictor for the Early Detection of Antibody-Mediated Rejection Following Heart Transplantation [0.03%]
移植后供体来源的细胞-freeDNA增加作为早期预测抗体介导的心脏排斥反应的指标
Dana Dlouha,Sarka Chytilova,Jevgenija Vymetalova et al.
Dana Dlouha et al.
Plasma circulating donor-derived cell-free DNA (ddcfDNA) can be used to noninvasively monitor acute rejection of heart transplants (HTx). This study utilized digital droplet PCR to analyze ddcfDNA concentrations (measured in copies per mill...
Tracking Acute Rejection in Heart Transplant Recipients by Using Donor-Derived Cell-Free DNA: A Promising Approach [0.03%]
利用游离DNA检测供体脱氧核糖核酸诊断心脏移植受者急性排斥反应是一项颇具前景的手段
Yan Qiu,Jianming Xia,Xiaoqi Wang
Yan Qiu
Biomarkers play a crucial role in posttransplant monitoring as they enable early detection of graft dysfunction and rejection, thereby facilitating personalized therapeutic interventions. Although recent studies have demonstrated the potent...
Exploring acute cellular rejection in lung transplantation: insights from donor-derived cell-free DNA analysis [0.03%]
供者衍生的无细胞DNA分析在肺移植急性细胞排斥反应中的应用及见解
Andrea Zajacova,Majd Alkhouri,Miray Guney et al.
Andrea Zajacova et al.
Background: Acute cellular rejection (ACR) is a frequent complication following lung transplantation, yet standardized guidelines for ACR screening remain lacking. This study aimed to compare the current gold standard for...
Correlation between Donor-Derived Cell-free DNA and Tissue Gene Expression in Heart Transplant Patients Undergoing for-cause Endomyocardial Biopsies [0.03%]
供者来源的游离DNA与心脏移植患者诊断性心内膜活检组织基因表达的相关性分析
Andrea Fernandez Valledor,Cathrine M Moeller,Daniel Oren et al.
Andrea Fernandez Valledor et al.
Introduction: The introduction of donor-derived cell-free DNA (dd-cfDNA) and the Molecular Microscope (MMDx) is changing how we diagnose rejection following heart transplantation (HT). This study aims to assess the accura...
Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review [0.03%]
肝移植中供者来源细胞游离DNA诊断和治疗应用进展与挑战：叙事综述
Yiwu Zhong,Xu Hu,Xiaoping Li et al.
Yiwu Zhong et al.
In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate ...
Absolute Quantification of Donor-Derived Cell-Free DNA Following Pediatric and Adult Heart Transplantation [0.03%]
儿童和成人心脏移植后供体来源的细胞-freeDNA的绝对定量
Jens Böhmer,Håkan Wåhlander,Karin Tran-Lundmark et al.
Jens Böhmer et al.
Objective: Traditional rejection surveillance after heart transplantation (HTx) is based on endomyocardial biopsies (EMB), which are invasive, expensive and associated with complications. Monitoring using cell-free DNA (c...
A Novel Method to Estimate Donor-Derived Cell-Free DNA in Pregnant Kidney Transplant Recipients: A Proof-of-Concept Study [0.03%]
评估怀孕肾移植受者供体来源细胞-freeDNA的新方法：概念验证研究
Jessica Tang,Lior Kashani Ligumsky,Kate Woodruff et al.
Jessica Tang et al.
Background: Pregnant kidney transplant recipients (KTRs) are a vulnerable, high-risk population, susceptible to obstetrical complications, as well as graft rejection. Current methods used to monitor kidney transplant func...
Donor-Derived Cell-Free DNA Versus Left Ventricular Longitudinal Strain and Strain-Derived Myocardial Work Indices for Identification of Heart Transplant Injury [0.03%]
捐赠者细胞游离DNA与左心室纵向应变及肌牵张机械做功指标在鉴定心脏移植损伤中的应用价值比较
Timea Teszak,Timea Barcziova,Csaba Bödör et al.
Timea Teszak et al.
Background/Objectives: Donor-derived cell-free DNA (dd-cfDNA) is a marker of graft injury that increases in acute rejection and has excellent negative predictive value. Left ventricular global longitudinal strain (LVGLS) and strain-derived ...
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