Increased expression of DNAJC7 promotes the progression of hepatocellular carcinoma by influencing the cell cycle and immune microenvironment [0.03%]
DNAJC7高表达通过影响细胞周期和免疫微环境促进肝癌进展
Jiaxing Chen,Zhizhao Yang,Yongqiang Cui et al.
Jiaxing Chen et al.
Background: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide owing to the lack of effective and early diagnostic tools and therapeutic approaches. DNAJC7, a member of the DnaJ heat...
The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity [0.03%]
DNAJC7介导HSP转录因子HSF1活化从而对抗蛋白毒性压力保护神经元的作用及其在ALS发病机制中的作用研究
Andrew C Fleming,Nalini R Rao,Matthew Wright et al.
Andrew C Fleming et al.
The degeneration of neurons in patients with amyotrophic lateral sclerosis (ALS) is commonly associated with accumulation of misfolded, insoluble proteins. Heat shock proteins (HSPs) are central regulators of protein homeostasis as they fol...
In Vivo-Matured Oocyte Resists Post-Ovulatory Aging through the Hub Genes DDX18 and DNAJC7 in Pigs [0.03%]
DDX18和DNAJC7基因维持体外成熟猪卵母细胞质量的研究
Cheng-Lin Zhan,Dongjie Zhou,Ming-Hong Sun et al.
Cheng-Lin Zhan et al.
Assisted reproduction technology (ART) procedures are often impacted by post-ovulatory aging (POA), which can lead to reduced fertilization rates and impaired embryo development. This study used RNA sequencing analysis and experimental vali...
Rare DNAJC7 Variants May Play a Minor Role in Chinese Patients with ALS [0.03%]
DNAJC7罕见变异可能在中国ALS患者中扮演较小的角色
Shichan Wang,Xiaoting Zheng,Qianqian Wei et al.
Shichan Wang et al.
DnaJ heat shock protein family member C7 gene (DNAJC7) has been identified as a genetic risk factor for amyotrophic lateral sclerosis (ALS). In our study, we aimed to screen for rare variants in DNAJC7 in a large cohort of Chinese ALS patie...
Valerie Ann Perez,David W Sanders,Ayde Mendoza-Oliva et al.
Valerie Ann Perez et al.
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large...
Valerie A Perez,David W Sanders,Ayde Mendoza-Oliva et al.
Valerie A Perez et al.
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large...
Hsp70 Inhibits the Replication of Fowl Adenovirus Serotype 4 by Suppressing Viral Hexon with the Assistance of DnaJC7 [0.03%]
DNAJ协同作用抑制禽腺病毒增殖效应研究进展
Jie Cao,Shuhui Liu,Meng Liu et al.
Jie Cao et al.
Fowl adenovirus serotype 4 (FAdV-4) infection results in serious hepatitis-hydropericardium syndrome (HHS) in broilers, which has caused great economic losses to the poultry industry; however, the specific host responses to FAdV-4 remain un...
Allison A Dilliott,Catherine M Andary,Meaghan Stoltz et al.
Allison A Dilliott et al.
Protein misfolding is a common basis of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Misfolded proteins, such as TDP-43, FUS, Matrin3, and SOD1, mislocalize and form the hallmark cytoplasmic and nuclear inc...
Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis [0.03%]
DNAJC7基因在散发性肌萎缩侧索硬化症日本患者中的突变筛查
Genki Tohnai,Ryoichi Nakamura,Naoki Atsuta et al.
Genki Tohnai et al.
DNAJC7 has recently been identified as an amyotrophic lateral sclerosis (ALS) gene via large-scale exome analysis, and its involvement in ALS is still unclear in various populations. This study aimed to determine the frequencies and charact...
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation [0.03%]
DNAJC7通过结合Tau蛋白固有无序区域来抑制其淀粉样纤维的形成
Zhiqiang Hou,Pawel M Wydorski,Valerie A Perez et al.
Zhiqiang Hou et al.
Molecular chaperones, including Hsp70/J-domain protein (JDP) families, play central roles in binding substrates to prevent their aggregation. How JDPs select different conformations of substrates remains poorly understood. Here, we report a...
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