Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer [0.03%]
靶向DNA解旋酶CMG复合物和NFκB2驱动的耐药转录轴有效治疗KRASG12D突变型胰腺癌
Jeffrey Xiao,Joshua Kim,Brandon Park et al.
Jeffrey Xiao et al.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a 5-year overall survival (OS) rate of approximately 12%. More than 90% of PDAC patients harbor oncogenic mutations in the Kirsten rat sarcoma viral homolog (KRAS) gen...
Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy [0.03%]
DDX11（Warsaw破碎综合症DNA解旋酶）调控自噬的细胞质功能的证据前所未有的细胞质功能
Raffaella Bonavita,Antonello Prodomo,Giuseppe Cortone et al.
Raffaella Bonavita et al.
DDX11 is a DNA helicase involved in critical cellular functions, including DNA replication/repair/recombination as well as sister chromatid cohesion establishment. Bi-allelic mutations of DDX11 lead to Warsaw breakage syndrome (WABS), a rar...
Mechanisms of Viral DNA Replication of Human Papillomavirus: E2 Protein-Dependent Recruitment of E1 DNA Helicase to the Origin of DNA Replication [0.03%]
人乳头瘤病毒DNA复制机制：E2蛋白介导的依赖DNA复制起点的E1 helicase的募集作用
Anshul Rana,Gulden Yilmaz,Esther E Biswas-Fiss et al.
Anshul Rana et al.
Human papillomaviruses (HPVs) are small double-stranded DNA viruses that infect epithelial cells and cause cervical, anogenital, and oropharyngeal cancers. HPV genome replication relies on the viral E1 and E2 proteins to initiate DNA replic...
Tissue-Specific Effects of the DNA Helicase FANCJ/BRIP1/BACH1 on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders [0.03%]
DNA解旋酶FANCJ/BRIP1/BACH1对脆性X相关障碍小鼠模型中重复扩增的组织特异性影响
Diego Antonio Jimenez,Alexandra Walker,Karen Usdin et al.
Diego Antonio Jimenez et al.
Fragile X-related disorders (FXDs) are caused by the expansion of a CGG repeat tract in the 5'-UTR of the FMR1 gene. The expansion mechanism is likely shared with the 45+ other human diseases resulting from repeat expansion, a process that ...
Adaptive Laboratory Evolution Uncovers Potential Role of a DNA Helicase Mutation in Torulaspora delbrueckii Increased Sulphite Resistance [0.03%]
适应性实验室进化揭示了DNA解旋酶突变在Torulaspora delbrueckii中增强亚硫酸盐抗性中的潜在作用
Carolina Osório,Ticiana Fernandes,Teresa Rito et al.
Carolina Osório et al.
Wine industry has faced pressure to innovate its products. Saccharomyces cerevisiae has been the traditional yeast for producing alcoholic beverages, but interest has shifted from the conventional S. cerevisiae to non-Saccharomyces yeasts f...
Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe [0.03%]
基于锚固定探针的解旋酶活性检测方法研究DNA helicase功能的特异性监控方法的研究基于锚固定探针
Keni Ning,Xiaoyan Tang,Zhe Li et al.
Keni Ning et al.
DNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase activity in living cells remains c...
Intercalating compounds alongside DNA helicase Q1 Plasmodium falciparum 3D7: Assessments of the Pharmacokinetic Properties Prediction of ADME [0.03%]
在恶性疟原虫DNA解旋酶Q1口袋中的嵌入化合物：药物动力学性质预测及ADME预测评估
Afnan Shakoori,Zain Alhindi,Mohammad Alobaidy et al.
Afnan Shakoori et al.
Background objectives: Quantum chemical & molecular docking practices to deliver new perceptions into how etoposide, novobiocin, nogalamycin and netropsin interact with the biological targets PF3D7_0918600 (Plasmodium fal...
DNA damage-induced phosphorylation of a replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function [0.03%]
DNA损伤诱导的DNA复制解旋酶磷酸化导致通过抑制解旋酶功能减少DNA复制
Caleb Homiski,Rama Dey-Rao,Shichen Shen et al.
Caleb Homiski et al.
A major function of the DNA damage responses (DDRs) that act during the replicative phase of the cell cycle is to inhibit initiation and elongation of DNA replication. It has been shown that DNA replication of the polyomavirus, SV40, is inh...
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation [0.03%]
转录过程中senataxin RNA/DNA解旋酶促进R-loop介导的复制重启以防止MUS81依赖性叉退化
Satyajeet Rao,Martin Andrs,Kaustubh Shukla et al.
Satyajeet Rao et al.
Replication forks stalled at co-transcriptional R-loops can be restarted by a mechanism involving fork cleavage-religation cycles mediated by MUS81 endonuclease and DNA ligase IV (LIG4), which presumably relieve the topological barrier gene...
Bloom syndrome DNA helicase mitigates mismatch repair-dependent apoptosis [0.03%]
布洛姆综合症DNA解旋酶通过降低错配修复介导的细胞凋亡来维持基因组稳定性
Yuka Uechi,Ryosuke Fujikane,Sho Morita et al.
Yuka Uechi et al.
Generation of O6-methylguanine (O6-meG) by DNA-alkylating agents such as N-methyl N-nitrosourea (MNU) activates the multiprotein mismatch repair (MMR) complex and the checkpoint response involving ATR/CHK1 and ATM/CHK2 kinases, which may in...
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