Evaluating the therapeutic role of salvianolic acid A on pancreatic cancer cells through interaction with the intrinsically disordered protein NUPR1 [0.03%]
评估丹参素A通过与内在无序蛋白NUPR1相互作用在胰腺癌细胞中的治疗作用
María Gabriela Álvarez-Rodríguez,Matías Estaras,Felipe Hornos et al.
María Gabriela Álvarez-Rodríguez et al.
Our model compound can hamper the pathological state (SG formation) triggered by this IDP, and indicates that the search for potential inhibitors of disordered proteins could be further extended to bioactive natural compounds.
Crossover in aromatic amino acid interaction strength between tyrosine and phenylalanine in biomolecular condensates [0.03%]
酪氨与苯氨在生物分子凝集物中相互作用强度的转换关系研究
David De Sancho,Xabier Lopez
David De Sancho
Biomolecular condensates often form through the self-assembly of disordered proteins with low-complexity sequences. In these polypeptides, the aromatic amino acids phenylalanine and tyrosine act as key 'sticker' residues, driving the cohesion of dense phases.
Radioprotection redefined: drug discovery at the intersection of tardigrade biology and translational pharmacology [0.03%]
放射学保护的重新定义：缓步动物生物学与转化药理学交叉领域的药物发现
Zhitao Cui,Cong Lin,Huiying Zhao et al.
Zhitao Cui et al.
In striking contrast, tardigrades (phylum Tardigrada) routinely endure exposures beyond 5 kGy by deploying a multifaceted defense repertoire that includes genome-shielding proteins such as damage suppressor (Dsup) and Tardigrade DNA-Repair protein 1 (TDR1), families of intrinsically disordered proteins
Uroš Zavrtanik,Jurij Lah,San Hadži
Uroš Zavrtanik
This has important implications for understanding the net energetic balance in protein folding and the interactions of intrinsically disordered proteins that undergo α-helix folding upon binding.
Lenette F Kjaer,Francesco S Ielasi,Thomas Winbolt et al.
Lenette F Kjaer et al.
Intrinsically disordered proteins (IDPs) often undergo folding-upon-binding to their partners via short linear motifs, typically 5-15 amino acids in length.
Michael Phillips,Andrea Holla,Magdalena Wojtas et al.
Michael Phillips et al.
Intrinsically disordered proteins (IDPs) are often rich in charged residues, and electrostatic interactions have a pronounced effect on their conformational distributions, interactions and functions.
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability [0.03%]
单分子形状记忆与网格重构相互作用决定了生物大分子凝聚体的粘弹性
Pablo L Garcia,Jerelle A Joseph
Pablo L Garcia
However, how condensate viscoelastic responses are encoded in the chemistries of their constituents-such as intrinsically disordered proteins (IDPs)-are not well understood.
Characterizing Structural and Kinetic Ensembles of Intrinsically Disordered Proteins Using Writhe [0.03%]
基于_WRITHE_表征内在无序蛋白的结构和动力学系综
Thomas R Sisk,Simon Olsson,Paul Robustelli
Thomas R Sisk
The biological functions of intrinsically disordered proteins (IDPs) are governed by the conformational states they adopt in solution and the kinetics of transitions between these states.
Fatima Tu Zahra,Hooreen Kayani,Samra Noreen et al.
Fatima Tu Zahra et al.
Synucleins α, β, and γ are inherently disordered proteins that play essential roles in neuronal physiology and are increasingly recognized as key players in neurodegenerative disease mechanisms.
Across (Conformational) Space and (Relaxation) Time: Using Coarse-Grain Simulations to Probe the Intra- and Interdomain Dynamics of the Tau Protein [0.03%]
跨越（构象）空间和（松弛）时间：使用粗粒化模拟来探究tau蛋白的结构域内及结构域间的动态行为
Jules Marien,Chantal Prévost,Sophie Sacquin-Mora
Jules Marien
The biological importance of intrinsically disordered proteins (IDPs) has been established for over two decades, yet these systems remain difficult to characterize, as they are better described by conformational ensembles instead of a single reference structure for their folded counterparts.
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