Novel fungal metabolites as dual cholinesterase inhibitors: A computational approach for Alzheimer's disease therapy [0.03%]
一种新的真菌代谢产物作为双重乙酰胆碱酯酶抑制剂的阿尔茨海默病治疗的计算方法研究
Md Habib Ullah Masum,Syed Mohammad Lokman,Rehana Parvin et al.
Md Habib Ullah Masum et al.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is a major global health concern, affecting millions worldwide, with its prevalence expected to triple by 2050. Despite the widespread use of traditional drugs like choline...
Crossing the blood-brain barrier: nanoparticle-based strategies for neurodegenerative disease therapy [0.03%]
穿越血脑屏障：基于纳米颗粒的神经退行性疾病治疗策略
Elena Haro-Martínez,Elena Muscolino,Núria Moral et al.
Elena Haro-Martínez et al.
Neurodegenerative conditions, including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Huntington's disease, represent a critical medical challenge due to their increasing prevalence, severe consequences, and absence of curati...
Targeting ferroptosis and mitophagy with neutrophil-inspired nanozyme for Parkinson's disease therapy [0.03%]
灵感启发的纳米酶靶向铁死亡和线粒体自噬治疗帕金森病
Yu Tian,Feng Wang,Jing Ma et al.
Yu Tian et al.
Parkinson's disease (PD) is characterized by neurodegeneration, oxidative stress, and α-synuclein aggregation. While L-DOPA provides symptomatic relief through dopamine replenishment, it lacks neuroprotective effects and fails to address o...
Macrophage polarization in disease therapy: insights from astragaloside IV and cycloastragenol [0.03%]
疾病治疗中的巨噬细胞极化：来自IV和CY的启示杂交苯并异噻唑酮-1-甲酸𬭩盐内铵盐类化合物
Bei-Bei Xiong,Yu-Mei Zhuo,Huan Wang et al.
Bei-Bei Xiong et al.
Dysregulated activation and polarization of macrophages drive the pathogenesis of diverse diseases, including inflammatory, autoimmune, ischemic, metabolic disorders, and cancers. Despite therapeutic advances, precise regulation of macropha...
Near-infrared light-triggered methylene blue/berberine co-loaded polydopamine nanoparticles modified with sialic acid for Alzheimer's disease therapy [0.03%]
用于阿尔茨海默病治疗的近红外光触发甲基蓝/小檗碱共负载聚多巴胺纳米粒子并用唾液酸修饰
Yueting Lv,Sajid Asghar,Panting Ye et al.
Yueting Lv et al.
Due to the existence of the blood-brain barrier (BBB) and the complicated pathological mechanisms of Alzheimer's disease (AD), current therapeutic approaches for AD show limited efficacy. To overcome these challenges, a multi-strategy drug ...
Correction to "Oral Administration of Bioactive Nanoparticulates for Inflammatory Bowel Disease Therapy by Mitigating Oxidative Stress and Restoring Intestinal Microbiota Homeostasis" [0.03%]
“通过减轻氧化应激和恢复肠道微生物平衡进行炎症性肠病治疗的生物活性纳米颗粒口服递送”的勘误通知
Hong Wu,Chengxin Shi,Qixin Li et al.
Hong Wu et al.
Published Erratum
Molecular pharmaceutics. 2025 Jun 2. DOI:10.1021/acs.molpharmaceut.5c00723 2025
The role of non-coding RNA regulates stem cell programmed death in disease therapy [0.03%]
非编码RNA在调控干细胞程序性死亡的疾病治疗作用
Ziling Liao,Weidong Liu,Lei Wang et al.
Ziling Liao et al.
Programmed cell death (PCD), an essential and inevitable phenomenon, is integral to organismal development. It not only maintains cellular homeostasis but also prevents aberrant cell proliferation, thereby protecting normal growth and devel...
Angiopep-2 modified naringin nanoparticles for Alzheimer's disease therapy overcoming BBB [0.03%]
用于治疗阿尔茨海默病的Angiopep-2修饰柚皮素纳米粒克服血脑屏障
Jing Jiang,Yue Xing,Shumeng Liu et al.
Jing Jiang et al.
Naringin (4',5,7-trihydroxyflavanone-7-rhamnoglucoside, NG), a potential treatment for Alzheimer's disease (AD), has strong neuroprotective effects but is limited by poor solubility, low bioavailability, and limited brain accumulation. To a...
Nano-formulations in disease therapy: designs, advances, challenges, and future directions [0.03%]
纳米制剂在疾病治疗中的设计、进展、挑战和未来方向
YunYan Shi,Xiao Li,Zhiyuan Li et al.
YunYan Shi et al.
Nano-formulations, as an innovative drug delivery system, offer distinct advantages in enhancing drug administration methods, improving bioavailability, promoting biodegradability, and enabling targeted delivery. By exploiting the unique si...
Xin Wu,Wantao Wu,Nam Jutaek et al.
Xin Wu et al.
Oral drug delivery systems (DDSs) show great advantages in patient compliance due to their convenience and non-invasiveness. Typically, oral DDSs are designed to deliver drugs to the specific gastrointestinal region, and normalize the dysre...
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