Inhibition of thioredoxin reductase 1 by evernic and vulpinic acids: a promising anticancer strategy on A549 cells [0.03%]
巴利尼酸和乌弗林酸通过抑制A549细胞硫氧还蛋白还原酶1抗肿瘤作用的研究
Şükran Günaydın,Şeyda Nur Kalın,Emine Karaca Sulukoğlu et al.
Şükran Günaydın et al.
The findings indicated that VA elicited a more notable cytotoxic activity in A549 cells (36.21 µg/mL) at a lower IC50 value than EA (139.09 µg/mL). Whereas, LA exhibited very low cytotoxic effect in A549 cells.
Palm oil nanoemulsion enhances tocotrienol stability, antioxidant, and selective anti-melanoma activity [0.03%]
棕榈油纳米乳液增强托可汀的稳定性、抗氧化和选择性抗黑色素瘤作用
Ahmad Fariduddin Aththar,Farhana Raushani,Fransiska Christydira Sekaringtyas et al.
Ahmad Fariduddin Aththar et al.
Tocotrienols (T3) have been known to have potential cytotoxic activity against cancer cells. However, their ability to effectively target cancerous tissue is hampered by their lipophilic characteristics and poor bioavailability.
Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models [0.03%]
胰腺癌模型中，通过转移酶激活的前药EAPB02303抑制微管聚合可增强紫杉醇的效果
Kévin Bigot,Cindy Patinote,Véronique Garambois et al.
Kévin Bigot et al.
Among these compounds, the lead EAPB02303 displays outstanding cytotoxic activity at nanomolar concentrations comparable to those of standard-of-care chemotherapy drugs in different cancer cell lines, including Pancreatic Ductal AdenoCarcinoma (PDAC) cell lines.
Crotalicidin and NA-CATH-ATRA-1-ATRA-1 peptide-induced membrane disruption in human breast cancer cells [0.03%]
铜头蛇肽和NA-CATH-ATRA-1-ATRA-1多肽诱导的人乳腺癌细胞膜损伤研究
Vanessa Gallego-Londoño,Gloria A Santa-González,Juan M Giraldo-Lorza et al.
Vanessa Gallego-Londoño et al.
This study investigates the cytotoxic activity and the membrane-disruptive effects of two snake venom-derived peptides, Crotalicidin (Ctn) and NA-CATH-ATRA-1-ATRA-1 (NA) in human breast cancer cells.
Design, synthesis, and molecular modeling of new 1,2,4-triazole-containing indole compounds as aromatase antagonists for the treatment of breast cancer [0.03%]
设计、合成并进行分子模拟获得新型含1,2,4-三唑结构的吲哚类化合物作为治疗乳腺癌的芳香化酶抑制剂研究
Ahmed Elrashedy,Noha E Ibrahim,Heba Abo-Salem et al.
Ahmed Elrashedy et al.
The results of the MTT assay indicated that compounds 4d and 5 exhibited significant cytotoxic activity against the MCF-7 cancer cell lines with IC50 values of 17.67 ± 0.34 and 17.01 ± 0.53 μM (respectively) compared with Cisplatin, which showed an IC50 value of 18.03 ± 0.71 μM.
Combining CD3/GD2 bispecific T cell engager with human Vγ9Vδ2 T cells facilitates neuroblastoma cell targeting and killing in vitro [0.03%]
双特异性的CD3/GD2双特异性T细胞衔接器与人Vγ9Vδ2T细胞结合可促进神经母细胞瘤体外靶向和杀伤作用
Kuntida Kitidee,Sumet Amonyingcharoen,Sarinthip Preedagasamzin et al.
Kuntida Kitidee et al.
The combination of CD3/GD2 BiTE and human Vγ9Vδ2 T cells also exhibited cytotoxic activity against a three-dimensional tumor spheroid model of SH-SY5Y GFP at an E:T ratio of 1:1.
Standardized analysis of nuclease activities in Mycoplasma species colonizing swine, poultry, and small ruminants [0.03%]
猪、家禽和小型家畜colo的支原体物种的标准酶分析方法
Manon Vastel,Patrice Gaurivaud,Florence Tardy et al.
Manon Vastel et al.
They help to provide nucleotides essential for bacterial growth by degrading host nucleic acids, are involved in the degradation of extracellular traps and hence in immune evasion, and can have direct cytotoxic activity in host cells.
Effect of Thermal Treatment on the Antiproliferative and Antioxidant Activities of Garlic [0.03%]
热处理对大蒜抗增殖和抗氧化活性的影响
Paulina Furdak,Grzegorz Bartosz,Izabela Sadowska-Bartosz
Paulina Furdak
Baking and steaming of garlic cloves decreased TAC and phenolic content, inactivated alliinase, decreased thiosulfinate content, and compromised the cytotoxic activity of garlic.
New Cyclopeptide and γ‑Butyrolactone Derivatives from an Endophytic Strain of Cophinforma mamane [0.03%]
采自马鞍树 Allococosspadensis 的内生真菌 Cophinformamamane 糖被素类新骨架化合物及 γ- 丁内酯衍生物
Clara Litot,Marieke Vansteelandt,Sergio Ortiz et al.
Clara Litot et al.
The two γ-butyrolactone derivatives (1, 2) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC50 = 13.33 and 4.43 μM, respectively), while only compound 2 displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity
Natural killer cell dysfunction is associated with colorectal cancer with severe COVID-19 [0.03%]
自然杀伤细胞功能障碍与严重COVID-19结直肠癌有关
Jun-Feng Wang,Lu-Zhou Zhang,Tao Liu et al.
Jun-Feng Wang et al.
NK cell cytotoxic activity (NKCA) and corresponding NK cytotoxic factor (NKCF) activity in peripheral blood mononuclear cells were evaluated using a Real-Time Cell Analyzer.
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