Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents [0.03%]
Faeze Nourmandipour,Reihane Emadi,Peyman Salehi et al.
Faeze Nourmandipour et al.
This compound, as starting material for the click reaction underwent 1,3-dipolar cycloaddition reaction with different azides to produce the target 1,2,3-triazole tethered derivatives of morphine. The anti-nociceptive properties of the products were evaluated by tail flick test.
Kana M Sureshan,Divina Xavier,Sourav Pathak et al.
Kana M Sureshan et al.
Upon heating at a temperature above 70 οC, each enantiomorphic crystal underwent a regiospecific and stereospecific topochemical ene-azide cycloaddition reaction in a single-crystal-to-single-crystal fashion to give a triazoline-linked homochiral helical polymer.
Synthesis of Perfluoro- tert-butyl Triazoles via Decarboxylative CuAAC of (Perfluoro- tert-butyl)propiolic Acid with Azides [0.03%]
Yao Chen,Zhiqiang Wei,Haixia Song et al.
Yao Chen et al.
A copper-catalyzed decarboxylative cycloaddition of (perfluoro-tert-butyl)propiolic acid (PFtPA) with azides under mild conditions was developed, enabling the facile synthesis of perfluoro-tert-butyl (PFtB) triazoles....The strong electron-withdrawing nature of the PFtB group facilitates efficient decarboxylative cycloaddition at 30 °C using catalytic copper acetate, avoiding the requirement of traditional harsh conditions.
Photodimerization of norbornenes and cyclohexenes catalyzed by Cu(I) complexes: mechanistic similarities and differences [0.03%]
Xin-Xin Liu,Jia-Jia Ma,Guo Li et al.
Xin-Xin Liu et al.
The Cu(I)-photocatalyzed cycloaddition reaction has become an important way to construct four-membered ring products. A recent experiment reported the photocycloaddition of norbornenes (nb) and cyclohexenes (ch) catalyzed by CuOTf. However, the atomic level details remain lacking.
HFIP-promoted synthesis of bicyclo[2.1.1]-hexanes through formal [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes with α-cyano chalcones [0.03%]
Kai Hu,Haijian Wu,Manman Sun et al.
Kai Hu et al.
A HFIP-promoted formal [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes with α-cyano chalcones has been reported, in which HFIP acts as the hydrogen-bond activator of both substrates, the stabilizer of carbocations and a co-solvent.
Fei Liu,Tongdao Wang
Fei Liu
The [3 + 2] cycloaddition of Lewis acidic alkenylboranes with aldehydes is described, providing a high-yielding and stereoselective approach for the synthesis of five-membered boron-containing heterocycles. Notably, alkenylboranes are used as three-atom B-C═C building blocks.
Elijah C Gonzalez,Isabel M de la Torre Roehl,Brian M Stoltz
Elijah C Gonzalez
Our de novo approach provided expedient access to the tetracyclic core of (+)-daphnepapytone A through an intramolecular allenyl thermal [2 + 2] cycloaddition and a Pauson-Khand reaction with a labile cyclobutane.
Understanding Small Molecule Activation Promoted by Heavier Benzene 1,4-diides: Interplay between Diradical Character and Aromaticity [0.03%]
理解重苯乙二胺促进的小分子活化：双自由基特性和芳香性之间的相互作用
Daniel González-Pinardo,Rajendra S Ghadwal,Israel Fernandez
Daniel González-Pinardo
Additionally, the key factors governing dihydrogen activation and cycloaddition with acetylene have been quantitatively analyzed in detail by applying the combination of the Activation Strain Model of reactivity and Energy Decomposition Analysis methods.
Mechanistic analysis of diverse click reactions along with their applications [0.03%]
各类点击反应的机理分析及其应用研究
Sushmita Bhatia,Avadh Biharee,Souren Mondal et al.
Sushmita Bhatia et al.
Most relevant reactions within the click chemistry framework, including copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted azide-alkyne cycloaddition (SPAAC), and other crucial methodologies like thiol-ene reactions are discussed along with their mechanisms.
Palladium-Catalyzed [3 + 2] Cycloaddition of Vinylethylene Carbonates with In Situ Generated Ketones from Diazo Compounds and DMSO [0.03%]
钯催化乙烯基乙二醇碳酸酯与偶氮化合物和DMSO原位生成酮的[3+2]环加成反应
Zemin Pan,Liying Fu,Zhilun Zhou et al.
Zemin Pan et al.
The palladium-catalyzed [3 + 2] cycloaddition of vinylethylene carbonates (VECs) with ketones presents significant challenges with only sporadic examples reported....Herein, we have developed an in situ generation strategy enabling the engagement of polycarbonyl-based ketones in [3 + 2] cycloaddition with VECs.
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