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Innovative Therapeutic Potential of Herbal Extracts Containing Punicic and Ellagic Acid: Addressing Lower Urinary Tract Disorders [0.03%] 富含番荔枝酸和 ellagic 酸的草药提取物治疗潜力创新性:应对下尿路疾病
Hrishav Das Purkayastha,Ranjit Prasad Swain,Abhishek Bhattacharjee Hrishav Das Purkayastha
The review also reflects on the use of herbal extracts in combination with current therapies as a synergistic approach, particularly on the healing effects of such combinations and the need for solid clinical evidence to support such claims.
Combination Therapy With Voclosporin and Anifrolumab in Two Patients With Lupus Nephritis and Discoid Lupus Erythematosus [0.03%] Voclosporin联合Anifrolumab治疗2例狼疮肾炎及盘状红斑狼疮患者
Arbor G Dykema,Ziga Vodusek,Ralina Karagenova et al. Arbor G Dykema et al.
Unfortunately, although many patients achieve an initial response with conventional immunosuppressant regimens, relapse is common, and current therapies are associated with damaging adverse effects and the risk of infection.
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome [0.03%] 武器化CRISPR/Cas9选择性清除基因组异常的细胞
Sara Tavella,Alessia di Lillo,Anastasia Conti et al. Sara Tavella et al.
Indeed, an intrinsic challenge of most current therapies against cancer and viral infections is the non-specific toxicity that they can induce in normal tissues because of their impact on important cellular mechanisms shared, to different extents, between unhealthy and healthy cells.
Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy [0.03%] 双组分T细胞免疫疗法实现抗原预靶向,在不降低疗效的前提下减少细胞因子的释放
M Tommy Gambles,Isaac Kendell,Jiahui Li et al. M Tommy Gambles et al.
This split antibody technology differs from current therapies by separating cancer cell-targeting components from T cell-engaging components.
Engineering an in vivo charging station for CAR-redirected invariant natural killer T cells to enhance cancer therapy [0.03%] 工程化体内充电站以增强CAR定向的不变自然杀伤T细胞癌症治疗效果
Song Li,Yan-Ruide Li,Haochen Nan et al. Song Li et al.
Through its biomimetic design and localized immunostimulatory effects, iMRAS helps overcome the limitations of current therapies for solid tumors, establishing a robust platform for enhancing systemic CAR-iNKT cell-mediated immunotherapy.
Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies [0.03%] 表观遗传调控核受体的作用机制及其在内分泌相关疾病治疗中的应用策略研究进展
Yixin Song,Kexin Zhang,Jingwen Zhang et al. Yixin Song et al.
It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches.
Revealing the Landscape Crosstalk Between Reproductive System and Organs Aging [0.03%] 揭示生殖系统与其他器官衰老的互作景观
Jiahong Wu,Peng Wu,Sicheng Wang et al. Jiahong Wu et al.
Additionally, this review summarizes current therapies aimed at delaying aging, which may provide insights for future interventions targeting the aging of the reproductive system and other systems.
Sustained Release of αO-Conotoxin GeXIVA[1,2] via Hydrogel Microneedle Patch for Chronic Neuropathic Pain Management [0.03%] 长效αO-康托克斯汀GeXIVA[1,2]水凝胶微针贴片用于慢性神经病理性疼痛管理
Rongyan He,Mingjuan Li,Weitao Li et al. Rongyan He et al.
Chronic neuropathic pain severely impairs quality of life, with current therapies often causing adverse effects. Our research group identified αO-conotoxin GeXIVA[1,2] as a potent analgesic candidate derived from marine cone snails.
Q14.92024 Marine drugs. 2025 Apr 7;23(4):161. DOI:10.3390/md23040161 2025
Drug Survival of Drugs Recommended for Irritable Bowel Syndrome: A Retrospective Observational Study [0.03%] 腹泻型肠易激综合征患者推荐药物的用药依从性研究:回顾性队列研究
Alice Sandberg-Janzon,Pontus Karling Alice Sandberg-Janzon
Conclusions: The overall 60-month drug survival for treatments prescribed in IBS is relatively low, suggesting that the effectiveness of current therapies remains limited.
Structure-based discovery of novel non-covalent small molecule inhibitors of USP30 [0.03%] 基于结构的新型非共价小分子USP30抑制剂发现
Padmanabhan Anbazhagan,Jothi Anantharajan,Justina Fulwood et al. Padmanabhan Anbazhagan et al.
Among them, USP30 plays a pivotal role in mitochondrial quality control and has been implicated in idiopathic pulmonary fibrosis (IPF), a chronic lung disease for which current therapies merely slow disease progression.
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