Nicotine exposure in adolescence triggers the activation and subsequent damage of microglia in the dentate gyrus and promotes depression later in life [0.03%]
尼古丁暴露诱发海马齿状回小胶质细胞活化及其随后的抑郁表型
Yunli Fang,Rongrong Yang,Rongrong Song et al.
Yunli Fang et al.
Adolescence is a critical period of neuroplasticity during which the brain can be affected by various harmful factors such as nicotine. Nicotine abuse in adolescence can promote depression in adulthood, but the underlying mechanisms are still unknown.
Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model [0.03%]
针对非典型DFNB9小鼠模型的耳蜗基因治疗恢复了听力和听觉处理能力
Najate Benamer,Hélène Le Ribeuz,Chloé Felgerolle et al.
Najate Benamer et al.
Conclusions: These findings indicate that gene therapy can address the entire spectrum of DFNB9 hearing loss, and that profound deafness during critical period may not impede the restoration of central auditory processing.
Jean Doherty,Margaret Folan,Aoife O&#x;Donoghue et al.
Jean Doherty et al.
Additionally, antenatal education should provide realistic portrayals of the transition to motherhood to prepare women for this critical period better.
Shujie Liu,Toru Kawanishi,Atsuko Shimada et al.
Shujie Liu et al.
These defects were detected at the early stages (4-48 hours post-fertilization), suggesting that the stages of progenitor development to heart looing were most susceptible to teratogen exposure, ie the critical period for teratogen-induced heart defects.
Sustained shift in the morphology of organic-walled microfossils over the Ediacaran-Cambrian transition [0.03%]
埃迪卡拉系-寒武系转折期有机壁微体化石形态的持续变化
Kelly E Tingle,Ross P Anderson,Neil P Kelley et al.
Kelly E Tingle et al.
Reconstructing the manner in which eukaryotes responded to these events represents an innovative lens with which to understand what these perturbations actually represent, as well as the links between geosphere and biosphere during a critical period in eukaryotic evolution.
Genome-wide quantitative dissection of an arthropod segmented body plan at single-cell resolution [0.03%]
在单细胞分辨率下对节肢动物体节体制的全基因组定量分析
Takanori Akaiwa,Hiroki Oda,Yasuko Akiyama-Oda
Takanori Akaiwa
Here, we present high-quality quantitative data from single-nucleus RNA sequencing of spider Parasteatoda tepidariorum embryos at late stage 5 and stage 7, a critical period of emergence of segmental units along the anterior-posterior (AP) axis.
Prevalence and infection characteristics of common pathogens associated with calf diarrhoea in Danish dairy calves [0.03%]
丹麦乳品农场犊牛腹泻相关常见病原的流行率及感染特征
John Elmerdahl Olsen,Birgitta Svensmark,Lene Agerskov et al.
John Elmerdahl Olsen et al.
Samples were primarily obtained from calves within the first two weeks (∼90 % of the samples), reflecting this critical period for diarrhoea development.
Exploring the use of exhaled breath profiling for non-invasive monitoring of cognitive functioning in children: a pilot study [0.03%]
儿童认知功能非侵入性监测中呼出气指纹应用的探索性研究：一项试点研究
Joris Meurs,Ben Henderson,Claudia van Dun et al.
Joris Meurs et al.
Introduction: Childhood is a critical period for the development of executive functioning skills, including selective attention and inhibitory control, which are essential for cognitive development.
Foxr1 deletion causes microcephaly and leads to cortical and hippocampal hypoplasia [0.03%]
Foxr1基因敲除引起小头畸形并导致皮层和海马发育不良
Hannah Waxman,Marcus Kankkunen,Arya Gupta et al.
Hannah Waxman et al.
This reduction correlates with decreased proliferation of progenitors (Ki67- and Tbr2-positive cells) at embryonic day 16.5 (E16.5), a critical period for upper-layer neurogenesis.
Enhanced excitability of CA1 pyramidal neurons during the latent phase of the Rat lithium-pilocarpine model of temporal lobe epilepsy [0.03%]
锂-筒箭毒碱诱导的大鼠颞叶癫痫潜伏期内CA1区锥体神经元兴奋性增强
Sergey L Malkin,Aleksey V Zaitsev
Sergey L Malkin
These changes were most pronounced on the 3rd day post-SE, coinciding with a critical period of epileptogenesis. Additionally, we observed a significant increase in the proportion of neurons exhibiting spike doublets, a phenomenon associated with enhanced excitability.
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