Satoshi Tsutsumi,Ikuko Ogino,Natsuki Sugiyama et al.
Satoshi Tsutsumi et al.
Among them, five were considered to have radiation-induced CCMs, four developing after cranial irradiation and one after endovascular therapy.
The glymphatic system in oncology: from the perspective of a radiation oncologist [0.03%]
从放射肿瘤学的角度看淋巴间质系统在肿瘤学中的作用
Kentaro Nishioka,Mariko Kawamura,Mami Iima et al.
Kentaro Nishioka et al.
Additionally, cranial irradiation has been suggested to impair the function of the glymphatic system.
Impact of prophylactic cranial irradiation on survival in extensive-stage small cell lung cancer receiving first-line chemoimmunotherapy: a propensity score-matched study [0.03%]
预防性全脑照射在广泛期小细胞肺癌一线化疗免疫治疗中的疗效研究：倾向性匹配分析
Shichao Zhou,Wanchen Zhai,Qian Zhang et al.
Shichao Zhou et al.
However, the role of prophylactic cranial irradiation (PCI) in the context of chemoimmunotherapy remains undefined.
Single-arm phase II study of consolidation serplulimab following hypofractionated radiotherapy with concurrent chemotherapy for patients with limited stage small-cell lung cancer: ASTRUM-LC01 study protocol [0.03%]
度伐利尤单抗巩固治疗伴低剂量放疗同步化疗后的局限期小细胞肺癌患者：ASTRUM-LC01研究方案
Yuqi Wu,Lei Deng,Jianyang Wang et al.
Yuqi Wu et al.
Prophylactic cranial irradiation is recommended for responding patients. Serplulimab will be delivered afterwards every 3 weeks for up to 1 year. Based on sample size estimation, 55 patients will be enrolled in total.
Prophylactic cranial irradiation in resected early stage small cell lung cancer: an updated systematic review and meta-analysis [0.03%]
局限期小细胞肺癌手术后的预防性全脑放疗：系统综述和meta分析的更新数据
Ze Yuan,Dan Tao,Dingyi Yang et al.
Ze Yuan et al.
Background: The use of prophylactic cranial irradiation (PCI) in early stage small cell lung cancer (SCLC) patients post-surgery remains controversial.
Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis [0.03%]
小胶质细胞再植通过恢复前额叶皮层活性和调节白三烯C4合成来逆转放射诱发的认知功能障碍
Yubo Hu,Zhe Li,Yafeng Zhu et al.
Yubo Hu et al.
In this study, we demonstrate that cranial irradiation induces hypoactivity in the medial prefrontal cortex (mPFC) of mice, leading to anxiety-like behaviors and memory impairments, which can be prevented by optogenetic activation of mPFC excitatory neurons.
It is premature to close the door on hippocampal avoidance in prophylactic cranial irradiation? [0.03%]
预防性全脑照射中回避海马坑道还为时过早？
Eric J Lehrer,William G Breen,Paul D Brown
Eric J Lehrer
Favorable Response to Conventional Chemoradiotherapy in Radiation-induced Glioma Harboring Coamplification of PDGFRA, KIT, and KDR: A Case Report and Literature Review [0.03%]
血小板源性生长因子受体A、KIT和血管内皮生长因子受体2共扩增的放射诱导型胶质瘤对常规放化疗敏感：1例报告及文献复习
Daisuke Tanikawa,Mitsuaki Shirahata,Kokyo Sakurada et al.
Daisuke Tanikawa et al.
One of the most serious complications of cranial radiotherapy is the development of radiation-induced glioma, which is estimated to occur in 1%-4% of patients who have received cranial irradiation and has a worse prognosis than sporadic glioblastoma.
Carboplatin, etoposide, atezolizumab, and bevacizumab in the first-line treatment of patients with extensive stage small-cell lung cancer: the GOIRC-01-2019 CeLEBrATE study [0.03%]
卡铂、依托泊苷、阿特珠单抗和贝伐珠单抗用于广泛期小细胞肺癌一线治疗的疗效：GOIRC-01-2019 CeLEBrATE研究
Giuseppe Lamberti,Karim Rihawi,Francesca Mazzoni et al.
Giuseppe Lamberti et al.
Prophylactic cranial irradiation and consolidation thoracic external radiotherapy were not permitted while on study treatment. Primary endpoint was overall survival (OS) rate at 1 year.
Real-World Analysis of Treatment Patterns in Limited-Stage Small Cell Lung Cancer: Implications for Clinical Practice [0.03%]
局限性小细胞肺癌的治疗模式分析及临床实践意义
Siyuan Yu,Xiaoyi Feng,Shengjie Li et al.
Siyuan Yu et al.
Prophylactic cranial irradiation (PCI) demonstrated comparable mOS (36.9 vs. 29.6 months, p = 0.27). Peripheral blood biomarkers (PBBs) lacked prognostic significance.
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