Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types [0.03%]
竞争的亚克隆和适应度多样性塑造癌症类型间的肿瘤进化路径
Hai Chen,Jingmin Shu,Rekha Mudappathi et al.
Hai Chen et al.
Intratumor heterogeneity arises from ongoing somatic evolution complicating cancer diagnosis, prognosis, and treatment. Here we present TEATIME (es t imating e volution a ry events t hrough s i ngle-ti m epoint s e quencing), a novel comput...
Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer [0.03%]
转移性前列腺癌中的雄激素受体基因组改变与耐药性问题
Edmond M Kwan,Alexander W Wyatt
Edmond M Kwan
Given the potential for cooccurrence of multiple AR genomic alterations in the same or competing subclones of a patient, it is distinctly challenging to attribute blanket clinical significance to any individual alteration.
Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral drift [0.03%]
人类抗体库选择信号：扫荡、竞争亚克隆和中性漂变
Felix Horns,Christopher Vollmers,Cornelia L Dekker et al.
Felix Horns et al.
Antibodies are created and refined by somatic evolution in B cell populations, which endows the human immune system with the ability to recognize and eliminate diverse pathogens. However, the evolutionary processes that sculpt antibody repe...
Gunes Gundem,Peter Van Loo,Barbara Kremeyer et al.
Gunes Gundem et al.
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths.
High-resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B-cell lymphoma and its large cell variant [0.03%]
高分辨率基因组谱分析揭示胃肠道边缘区B细胞淋巴瘤及其大细胞变异型的克隆进化和竞争
Lucia Flossbach,Karlheinz Holzmann,Torsten Mattfeldt et al.
Lucia Flossbach et al.
We found genomic heterogeneity in both cases, supporting the theory of competing subclones in the evolution and progression of extranodal marginal zone B-cell lymphoma. Copyright © 2012 UICC.
Reliable detection of subclonal single-nucleotide variants in tumour cell populations [0.03%]
可靠检测肿瘤细胞群体中的亚克隆单核苷酸变异
Moritz Gerstung,Christian Beisel,Markus Rechsteiner et al.
Moritz Gerstung et al.
According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours.
Jonathan J Keats,Marta Chesi,Jan B Egan et al.
Jonathan J Keats et al.
A detailed analysis of one high-risk patient sampled at 7 time points over the entire disease course identified 2 competing subclones that alternate in a back and forth manner for dominance with therapy until one clone underwent a dramatic linear evolution.