Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways [0.03%]
环境丰富通过miRNA-132和HDAC3信号通路防止Aβ寡聚体诱导的突触功能障碍
Zhiyun Wei,Xingjun Meng,Rachid El Fatimy et al.
Zhiyun Wei et al.
Our findings provide a rationale for prolonged exposure to cognitive novelty and/or epigenetic modulation to lessen the progressive effects of Aβ accumulation during human brain aging.
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers [0.03%]
环境新颖性通过激活β₂-肾上腺素能信号通路防止Aβ寡聚体对海马LTP的损害作用
Shaomin Li,Ming Jin,Dainan Zhang et al.
Shaomin Li et al.
These mechanistic insights support using prolonged exposure to cognitive novelty and/or oral β-adrenergic agonists to lessen the effects of Aβ accumulation during aging. Copyright © 2013 Elsevier Inc.
Thomas G Reio Jr,Namok Choi
Thomas G Reio Jr
Multivariate analysis of variance, 2 x 5 (Gender x Age), showed that cognitive novelty seeking increased significantly among participants younger than 50 years of age. Sensational novelty seeking was lower among women older than 40 years and among men older than 50 years.
E Goldberg,K Podell,M Lovell
E Goldberg
The two hemispheres are functionally different in ways not adequately captured by the classic distinction between linguistic and nonlinguistic processes. The right hemisphere is critical for processing novel cognitive situations. The left h...