Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents [0.03%]
Faeze Nourmandipour,Reihane Emadi,Peyman Salehi et al.
Faeze Nourmandipour et al.
This compound, as starting material for the click reaction underwent 1,3-dipolar cycloaddition reaction with different azides to produce the target 1,2,3-triazole tethered derivatives of morphine. The anti-nociceptive properties of the products were evaluated by tail flick test.
Controlled/″Living″ Click Polymerization with Possible Bidirectional Chain-Growth Propagation during Polyaddition [0.03%]
可控／“活性”点击聚合及其加聚过程中可能的双向链增长反应
Satoshi Sakai,Takuya Nakamura,Seiichiro Uchida et al.
Satoshi Sakai et al.
In this work, we found a new class of controlled/″living″ polymerization system, which proceeds bidirectional fashion using click reaction of AB monomer bearing azide and alkyne functionalities in a single molecule.
Sustainable catalysis with cellulose-copper: A review of click reaction applications [0.03%]
基于纤维素-铜的可持续催化点击反应研究进展综述
Zhor Ou-Ichen,Abdelghani Boussetta,Zineb Kassab et al.
Zhor Ou-Ichen et al.
In recent years, there has been a growing emphasis on the development of eco-friendly heterogeneous catalysts. This trend is largely driven by the advantages of heterogeneous catalysts, including their ease of handling, recoverability, and ...
Construction of a molecularly imprinted electroluminescence sensor for pyrimethanil detection via dummy template imprinting combined with click-chemical labeling of mimic enzymes [0.03%]
伪模板印迹结合仿酶点击化学标记的哒螨灵电致发光分子印迹传感器的构建
Lijuan Lin,Peng Gao,Minjin Wu et al.
Lijuan Lin et al.
Then, Fe/N-PAMAM-SH, a dendritic polymer bound with Fe/N CDs, was immobilized onto the MIP via the Thiol-ene click reaction between Fe/N-PAMAM-SH and PMT-Vi.
Self-Replenishable Metabolically Augmented Synbiotic Microspheres Remodel Gut-Bone Homeostasis [0.03%]
代谢增强的合生元微球重塑肠骨稳态
Zhijie Chen,Hua Liu,Yi Chen et al.
Zhijie Chen et al.
In this study, commencing with the sequencing of fecal samples from clinical patients with PMO, a self-replenishable metabolically augmented synbiotic microsphere (SMASM) is fabricated via a thiol-ene click reaction to restore gut-bone homeostasis using Lactobacillus rhamnosus GG (LGG) as a viable metabolic
Accessing a Hidden Pathway to Supramolecular Toroid through Vibrational Strong Coupling [0.03%]
通过振动强耦合访问超分子环状结构的隐藏途径
Shunsuke Imai,Takumi Hamada,Misa Nozaki et al.
Shunsuke Imai et al.
The supramolecular polymers with reactive ethynyl groups undergo a transformation from long fibers to thick fibers upon induction by an amino-yne click reaction in the absence of VSC....Under VSC of the C-H stretch, the click reaction within supramolecular polymers is accelerated; no such acceleration occurs in the reaction of individual monomers, suggesting that the acceleration is due to changes in the assembled structures.
A phenotype-independent "label-capture-release" process for isolating viable circulating tumor cells in real-time drug susceptibility testing [0.03%]
一种基于表型无关的“标记-捕获-释放”过程，可在实时药物敏感性试验中分离出活循环肿瘤细胞
Zhiqi Lao,Xiaoxue Ren,Dehua Zhuang et al.
Zhiqi Lao et al.
By utilizing bio-orthogonal plates designed with dibenzocyclooctane (DBCO) and disulfide groups, with the aid of anti-fouling effects, CTCs labeled with azido groups can be captured through a copper-free click reaction and subsequently released via disulfide reduction.
New Trends in Click Reactions for Synthesis of 1,2,3-Triazole Derivatives [0.03%]
最新点击反应合成1,2,3-三唑衍生物研究进展
Shivangi Jaiswal,Khushboo Bhardwaj,Jaya Dwivedi et al.
Shivangi Jaiswal et al.
The Cu-catalyzed click reaction has gained significant attention from investigators for the selective synthesis of triazole derivatives, but the toxicity occurs due to excessive presence of copper in the final product and associated intake limits its application.
Integrating click chemistry into protein expression for efficient preparation of immobilized protein bio-surface with enhanced stability and reproducibility in affinity chromatography [0.03%]
基于点击化学的固定化亲和层析用重组蛋白高效制备及稳定性研究
Xue Zhao,Yunshan Wang,Jiatai Yin et al.
Xue Zhao et al.
Herein, this work developed a method by integrating a thiol-ene addition click reaction during the protein expression for preparation of immobilized protein.
Injectable pH-Responsive Hydrogel Adapted to Gingival Crevicular Fluid Microenvironment for Periodontitis Therapy [0.03%]
用于牙周炎治疗的可注射pH响应性水凝胶适应龈沟液微环境
Zhongming Xia,Bin Zhao,Jie Xiang et al.
Zhongming Xia et al.
To address this pathological specificity, we developed an alkaline-responsive dynamic hydrogel through the stepwise sulfhydryl click reaction between a four-arm poly(ethylene glycol) (PEG)-thiol and alkyne crosslinkers, enabling efficient encapsulation of bioactive rutin within the hydrogel matrix.
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