Hongxi Li,Lanqing Zhao,Jinwei Li et al. Hongxi Li et al.

By examining the apolipoprotein E (APOE) together with the triggering receptor expressed on myeloid cells 2 (TREM2), this study aims to clarify their joint function in modulating differentiation and how this interplay might be implicated in chronic pain associated with NPC....In vivo studies involved macrophage depletion and TREM2 knockdown in mouse models to evaluate the impact on chronic pain development....TREM2 knockdown in macrophages resulted in a reduction of chronic pain behaviors in mouse models, highlighting the contribution of the APOE-TREM2 Axis to NPC-associated chronic pain....Our findings demonstrate that NPC cells promote macrophage reprogramming through the APOE-TREM2 Axis, leading to neuron-like differentiation and contributing to chronic pain in NPC patients....Targeting this pathway may offer novel therapeutic strategies for managing chronic pain in NPC.

Yong Yang,Huajun Wang,Huige Hou et al. Yong Yang et al.

Appropriate formation of blood vessels is critical for tendon-bone healing during tendon injury, as excessive angiogenesis would exacerbate scar formation and lead to chronic pain and dysfunction.

Ayadi Yacine,Muhammad Zain Ali,Amal Bayen Alharbi et al. Ayadi Yacine et al.

Infections, particularly viral and bacterial agents, trigger inflammatory responses through mechanisms such as molecular mimicry and bystander activation, leading to chronic pain and neuropathy.

Emma E Guld,Katherine R Guld,Tristan Tinney et al. Emma E Guld et al.

Complex regional pain syndrome (CRPS) is a chronic pain condition causing severe pain, sensory disturbances, and functional impairments, disproportionately affecting adolescent females.

Akira Hashimoto,Yasuhide Morioka,Shihomi Wada et al. Akira Hashimoto et al.

However, limited evidence exists regarding the incidence of OIC, as diagnosed using the Rome IV criteria, in non-cancer patients newly prescribed weak opioids for chronic pain in Japan.

Patrick H Finan,Luana Colloca Patrick H Finan

Allison M Barry,Julia R Sondermann,Joseph B Lesnak et al. Allison M Barry et al.

The peripheral nervous system (PNS) plays a critical role in pathological conditions, including chronic pain disorders, that manifest differently in men and women.

Tjitske D Groenveld,Pim van Dorst,Richard P G Ten Broek et al. Tjitske D Groenveld et al.

However, knowledge gaps regarding the effectiveness of VR, the incidence of chronic postoperative pain, and societal costs of chronic pain need to be addressed, to better understand VR therapy's role in optimizing postoperative pain management.

Ida Flink,Maryam Al-Khafadji,Sofia Ring et al. Ida Flink et al.

Noteworthy, levels of pain catastrophizing in the severe FOC group were similar to those reported in chronic pain samples.

Philipp Niklas Ostermann,Victoria J Madden,Harriet I Kemp et al. Philipp Niklas Ostermann et al.