A multimodal imaging nanobubble enhancing sonodynamic therapy by cell membrane disruption for effective anti-melanoma [0.03%]
一种多模态成像纳米气泡通过破坏细胞膜增强体声动力学治疗以有效抗黑色素瘤
Ziyan Feng,Yongchao Yao,Ziyao Wang et al.
Ziyan Feng et al.
However, direct use of sonosensitizer like chlorin e6 (Ce6) may face problems like poor drug solubility and off-target effects. Besides, using SDT alone may be deficient to treat melanoma.
A smart all-in-one strategy based on hybrid bacteria with targeting drug delivery and spatiotemporal drug release to boost the synergistic therapeutic efficacy against TNBC [0.03%]
一种智能一体化策略：兼具靶向递药与时空药物释放功能的杂化细菌，用于增强对三阴性乳腺癌的协同治疗效应
Wenzhe Yuan,Xiaoli Jiang,Jiayang Qin et al.
Wenzhe Yuan et al.
Therefore, engineered Escherichia coli Rosetta(DE3) expressing PD-L1 nanobody (Rosetta(pPD-L1nb)) are constructed and covalently conjugated with a photosensitizer, chlorin e6 (Ce6), to develop hybrid bacteria (CeRosetta(pPD-L1nb)).
Deciphering the Physical Binding Mechanism of Enzyme-Photosensitizer Facilitates Catalysis-Augmented Photodynamic Therapy [0.03%]
揭示酶-光敏剂物理结合机制可增强催化增效光动力治疗
Bingqing Jia,Yang Liu,Xudong Geng et al.
Bingqing Jia et al.
Here, we systematically investigate the interacting behaviors of representative enzymes with one of the most popular PS of chlorin e6 (Ce6) and elucidate their binding dynamics and crucial determinants.
Electronic strong coupling modifies the ground-state intermolecular interactions in self-assembled chlorin molecules [0.03%]
电子强耦合改变了自组装叶绿素分子间的相互作用
Subha Biswas,Mainak Mondal,Gokul Chandrasekharan et al.
Subha Biswas et al.
The spin-cast films of chlorin e6 trimethyl ester (Ce6T) show an excitonic coupling band in absorption resulting from their ground-state intermolecular interactions and subsequent excimer-like emission upon photoexcitation.
Multifunctional Silk Fibroin Nanocarriers Loaded with Chlorin e6 for PDT/PTT Synergistic Elimination of Drug-Resistant Bacteria and Biofilms [0.03%]
载有血红素e6的多功能丝素蛋白纳米载体用于耐药细菌和生物膜的光动力治疗/光热治疗协同消除研究
Feiyang Xu,Ting Cui,Zhendong Long et al.
Feiyang Xu et al.
The development of drug-resistant biofilms has resulted in treatment failures for multidrug resistant (MDR) bacteria, presenting a substantial challenge to global public health. Consequently, the development of antibacterial agents has beco...
A Facile Coordination Polymer Nanoparticle for Sonodynamic Therapy Combating Drug-Resistant Bacteria [0.03%]
一种用于声动力治疗抗药性细菌的简便配位聚合纳米颗粒
Xianhui Song,Jie Li,Siyuan Huang et al.
Xianhui Song et al.
By conjugating the Food and Drug Administration (FDA)-approved safe sonosensitizer porphyrin chlorin e6 (Ce6) with a positively charged antimicrobial peptide LL37 through coordination interaction, the resultant LZC exhibits uniform size and a positively charged surface, which is beneficial for the efficient
Peptide-based nanoassembly enhances ferroptosis in cancer to overcome paclitaxel resistance [0.03%]
基于肽的纳米结构通过增强癌症细胞铁死亡来克服紫杉醇耐药性
Congcong Lin,Jiamin Sun,Yun Yang et al.
Congcong Lin et al.
Herein, a peptide-based nanoassembly (PTX@CPG) consisting of paclitaxel (PTX), chlorin e6 (Ce6), and FFVLKPLGLAGK-(PEG8)3 was constructed to promote ferroptosis through reactive oxygen species (ROS) accumulation and overcome chemoresistance.
A Smart DNA Nanoframework Enables Synergistic Photodynamic Therapy of Pancreatic Cancer [0.03%]
一种智能DNA纳米框架用于协同光动力学治疗胰腺癌
Nachuan Song,Hongjin Li,Ruoyu Tao et al.
Nachuan Song et al.
To address this challenge, a smart DNA nanoframework capable of controlled co-delivery of Cas9 ribonucleoprotein (RNP), hemin, and chlorin e6 (Ce6) to enable synergistic PDT for PDAC is developed.
A core-shell structured biphasic microneedle system as an elite squad for combating melanoma with "three-in-one" therapeutic power [0.03%]
一种具有“三位一体”治疗功效的用于抗击黑色素瘤的核心-壳结构双相微针系统精英小分队
Qiling Jin,Ying Wang,Wenwen Lei et al.
Qiling Jin et al.
Meanwhile, the core section of MN, constructed from hyaluronic acid, acts as a "bow and arrow" to preserve the bioactivity of chlorin e6 nanoparticles for launching an effective "attack" on melanoma cells through photodynamic therapy.
Supramolecular Antigen Peptide Nanoparticles for Enhanced Photodynamic Therapy and Immunotherapy against Tumors [0.03%]
超分子抗原肽纳米颗粒用于肿瘤光动力治疗和免疫治疗增强疗法
Ya Zhang,Jianwei Bao,Chen Jiang et al.
Ya Zhang et al.
The E7 antigen peptide nanoparticles (E7 NPs) are further functionalized by loading chlorin e6 (Ce6) and decorating with bovine serum albumin (BSA), generating BSA/E7/Ce6 NPs.
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