Plant-derived nodule-specific cysteine-rich peptides as potent antifungal agents against Cryptococcus neoformans: mechanisms of action, chimeric peptide enhancement, and immunomodulatory effects [0.03%]
来源于植物的结节特异性半胱氨酸丰富多肽作为抗新生隐球菌的强大抗真菌剂：作用机制、嵌合肽增强和免疫调节效应
Bettina Szerencsés,Csaba Papp,Alexandra Pál et al.
Bettina Szerencsés et al.
The basidiomycetous yeast Cryptococcus neoformans is classified among the four critical fungal pathogens due to its capability of inducing life-threatening meningitis in immunocompromised individuals, particularly AIDS patients. The increas...
A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy [0.03%]
一种自组装的三合一肽系杆系统用于精准光动力治疗
Qishu Jiao,Tingting Zhang,Shuyao Zhou et al.
Qishu Jiao et al.
STATEMENT OF SIGNIFICANCE: This study presents a self-assembled chimeric peptide nanoplatform (PpIX-1-DG NPs) that integrates a 'three-in-one' mechanism, enabling auto-activation, cascade amplification, and self-reporting functions for precision photodynamic therapy while allowing real-time monitoring
An endoplasmic reticulum-targeting photodynamic AMPK agonist activates breast cancer immunotherapy through promoting immunogenic cell death and downregulation of PD-L1 [0.03%]
靶向内质网的光动力学AMPK激动剂通过促进免疫原性细胞死亡和下调PD-L1增强乳腺癌免疫治疗
Ye-Yang Wu,Ke-Yang Zhang,Jia-Qi Huang et al.
Ye-Yang Wu et al.
PPFC comprised a chimeric peptide (PpIX-(PEG8-FFKDEL)2) integrating a photosensitizer protoporphyrin IX (PpIX), a hydrophilic PEG8 linker, and the ER-targeting peptide sequence FFKDEL....The amphiphilic structure of the chimeric peptide facilitated its self-assembly into nanomicelles capable of encapsulating the AMPK agonist COH-SR4 (CS) within the chimeric peptide, forming PPFC.
Design of antinociceptive peptide by grafting domains between scorpion β-neurotoxins [0.03%]
通过嫁接方法设计抗痛觉肽：来源于东亚钳蝎β-毒素中的功能片段及其作用机制研究
Pavel Andrei Montero-Dominguez,Rita Restano-Cassulini,Lizeth Carolina Magaña-Ávila et al.
Pavel Andrei Montero-Dominguez et al.
Because of this, we used computational methods and the amino acid sequence of the novo recombinant neurotoxin rCssII-RCR to graft in some of its domains existing amino acids from the non-lethal CeII8 to generate a chimeric peptide with antinociceptive activity, named rCssII-Del-D23A-TCD.
GLP-1 receptor agonist properties of a chimeric peptide derived by hybridization of Latrodectus αLatrotoxin and Heloderma Exendin-4 [0.03%]
一种嵌合多肽的胰高血糖素样肽-1受体激动活性：此多肽由美洲箭毒蜘蛛α-大毒素与蛤蚧石龙子衍生的外源素-4杂交而成
Oleg G Chepurny,Amber N Liles,Nancy Cham et al.
Oleg G Chepurny et al.
Structural modeling studies of the predicted BW-Ex-4 binding sites at GPCRs of Family B provide new insights concerning the molecular basis for chimeric peptide stimulatory actions at the GLP-1R....Collectively, these findings establish combinatorial chimeric peptide chemistry in which αLTX serves as a molecular scaffold for the design of hybrid peptides with novel GPCR stimulating properties.
A novel multi-functional chimeric peptide for enhanced safe gene delivery in immunotherapy [0.03%]
一种用于免疫治疗的多功能嵌合肽增强安全基因传递的新方法
Mahdiyar Dehshiri,Shokouh Rezaei,Saman Hosseinkhani
Mahdiyar Dehshiri
Here, we designed a new multi-functional chimeric peptide for enhanced gene delivery by adding a cyclic TAT motif to a previously designed MPG2H peptide to enable the targeting of cells with independent/dependent endocytosis cell entry mechanisms....CTATMPG2H was compared with MiRGD as a chimeric peptide control in all steps. After assessing the platform stability in various conditions, its gene transfer efficiency was evaluated in the HEK293T cell line with reporter genes.
The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake and Energy Expenditure in Diet-Induced Obese Rats [0.03%]
嵌合肽(GEP44)通过减少摄食和产热以外的机制降低肥胖大鼠体重
Matvey Goldberg,James E Blevins,Tami Wolden-Hanson et al.
Matvey Goldberg et al.
We recently reported that a chimeric peptide (GEP44) targeting the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2- receptors decreased body weight (BW), energy intake, and core temperature in diet-induced obese (DIO) male and female mice.
RAS70 peptide targets multiforme glioblastoma by binding to the plasma membrane heat shock protein HSP70 [0.03%]
RAS70多肽通过与细胞膜HSP70蛋白结合靶向胶质肉瘤干细胞
Maxim Shevtsov,Natalia Yudintceva,Danila Bobkov et al.
Maxim Shevtsov et al.
current study, to further increase the bioavailability as well as penetration capacity through the blood-brain barrier (BBB) of the mHsp70-targeted peptide TKDNNLLGRFELSG, which is known to bind to the oligomerization sequence of mHsp70 chaperone, the latter was conjugated with tripeptide RGD (forming chimeric...peptide termed RAS70).
Evaluation of cylindrical micelles assembled from amphiphilic β-peptides as antigen delivery nanostructures [0.03%]
评估两亲性β-肽组装的柱状胶束作为抗原递送纳米结构的能力
Clément Martin,Mélanie Côté-Cyr,Phuong Trang Nguyen et al.
Clément Martin et al.
The chimeric peptide assembled into biocompatible unbranched filaments that exposed the antigen on the surface, and these filaments were readily internalized by dendritic cells and activated the toll-like receptor 2/6.
Plasma Membrane Targeted Photodynamic Nanoagonist to Potentiate Immune Checkpoint Blockade Therapy by Initiating Tumor Cell Pyroptosis and Depleting Infiltrating B Cells [0.03%]
通过引发肿瘤细胞焦亡和耗竭浸润B细胞来增强免疫检查点阻断治疗的靶向膜动态纳米激动剂
Ying-Tao Zhong,Zi-Wen Qiu,Ke-Yan Zhang et al.
Ying-Tao Zhong et al.
PMTPN is composed of a rationally designed chimeric peptide sequence loaded with Bruton's tyrosine kinase inhibitor (Ibrutinib).
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